Human Gene RBMS1 (ENST00000348849.8) from GENCODE V44
Description: Homo sapiens RNA binding motif single stranded interacting protein 1 (RBMS1), transcript variant 1, mRNA. (from RefSeq NM_016836) RefSeq Summary (NM_016836): This gene encodes a member of a small family of proteins which bind single stranded DNA/RNA. These proteins are characterized by the presence of two sets of ribonucleoprotein consensus sequence (RNP-CS) that contain conserved motifs, RNP1 and RNP2, originally described in RNA binding proteins, and required for DNA binding. These proteins have been implicated in such diverse functions as DNA replication, gene transcription, cell cycle progression and apoptosis. Several transcript variants, resulting from alternative splicing and encoding different isoforms, have been described. A pseudogene for this locus is found on chromosome 12. [provided by RefSeq, Feb 2009]. Gencode Transcript: ENST00000348849.8 Gencode Gene: ENSG00000153250.21 Transcript (Including UTRs) Position: hg38 chr2:160,272,151-160,493,807 Size: 221,657 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr2:160,275,637-160,493,363 Size: 217,727 Coding Exon Count: 13
ID:RBMS1_HUMAN DESCRIPTION: RecName: Full=RNA-binding motif, single-stranded-interacting protein 1; AltName: Full=Single-stranded DNA-binding protein MSSP-1; AltName: Full=Suppressor of CDC2 with RNA-binding motif 2; FUNCTION: Single-stranded DNA binding protein that interacts with the region upstream of the MYC gene. Binds specifically to the DNA sequence motif 5'-[AT]CT[AT][AT]T-3'. Probably has a role in DNA replication. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Highest amounts are found in placenta, lung and heart. DEVELOPMENTAL STAGE: Expressed at highest levels during the G1 to S transition of the cell cycle. SIMILARITY: Contains 2 RRM (RNA recognition motif) domains. SEQUENCE CAUTION: Sequence=AAX93095.1; Type=Erroneous gene model prediction; Sequence=CAA45923.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=CAA45923.1; Type=Frameshift; Positions=319, 360; Sequence=CAA54628.1; Type=Erroneous translation; Note=Wrong coding sequence;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P29558
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
