Human Gene SLC38A11 (ENST00000409149.7) from GENCODE V44
  Description: Homo sapiens solute carrier family 38 member 11 (SLC38A11), transcript variant 5, mRNA. (from RefSeq NM_001351539)
Gencode Transcript: ENST00000409149.7
Gencode Gene: ENSG00000169507.10
Transcript (Including UTRs)
   Position: hg38 chr2:164,898,329-164,955,486 Size: 57,158 Total Exon Count: 11 Strand: -
Coding Region
   Position: hg38 chr2:164,898,437-164,952,767 Size: 54,331 Coding Exon Count: 10 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:164,898,329-164,955,486)mRNA (may differ from genome)Protein (406 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: S38AB_HUMAN
DESCRIPTION: RecName: Full=Putative sodium-coupled neutral amino acid transporter 11;
FUNCTION: Putative sodium-dependent amino acid/proton antiporter (By similarity).
SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential).
SIMILARITY: Belongs to the amino acid/polyamine transporter 2 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 5.55 RPKM in Spleen
Total median expression: 57.36 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -146.60292-0.502 Picture PostScript Text
3' UTR -9.50108-0.088 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR013057 - AA_transpt_TM

Pfam Domains:
PF01490 - Transmembrane amino acid transporter protein

ModBase Predicted Comparative 3D Structure on Q08AI6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0015171 amino acid transmembrane transporter activity

Biological Process:
GO:0003333 amino acid transmembrane transport
GO:0006811 ion transport
GO:0006814 sodium ion transport
GO:0006865 amino acid transport

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK293998 - Homo sapiens cDNA FLJ58132 complete cds, weakly similar to Vacuolar amino acid transporter 2.
AK097141 - Homo sapiens cDNA FLJ39822 fis, clone SPLEN2011830.
BC125156 - Homo sapiens solute carrier family 38, member 11, mRNA (cDNA clone IMAGE:40120872), with apparent retained intron.
BC125157 - Homo sapiens solute carrier family 38, member 11, mRNA (cDNA clone MGC:150450 IMAGE:40120878), complete cds.
JD503016 - Sequence 484040 from Patent EP1572962.
KJ895653 - Synthetic construct Homo sapiens clone ccsbBroadEn_05047 SLC38A11 gene, encodes complete protein.
JD060566 - Sequence 41590 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AVT2, B4DF99, ENST00000409149.1, ENST00000409149.2, ENST00000409149.3, ENST00000409149.4, ENST00000409149.5, ENST00000409149.6, NM_001351539, Q08AI6, Q8N887, S38AB_HUMAN, uc002ucw.1, uc002ucw.2, uc002ucw.3
UCSC ID: ENST00000409149.7
RefSeq Accession: NM_001199148
Protein: Q08AI6 (aka S38AB_HUMAN)
CCDS: CCDS56142.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.