Human Gene PPIG (ENST00000462903.6) from GENCODE V44
Description: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. (from UniProt Q13427) Gencode Transcript: ENST00000462903.6 Gencode Gene: ENSG00000138398.17 Transcript (Including UTRs) Position: hg38 chr2:169,584,387-169,633,557 Size: 49,171 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr2:169,604,042-169,633,304 Size: 29,263 Coding Exon Count: 10
ID:PPIG_HUMAN DESCRIPTION: RecName: Full=Peptidyl-prolyl cis-trans isomerase G; Short=PPIase G; Short=Peptidyl-prolyl isomerase G; EC=5.2.1.8; AltName: Full=CASP10; AltName: Full=Clk-associating RS-cyclophilin; Short=CARS-Cyp; Short=CARS-cyclophilin; Short=SR-cyclophilin; Short=SR-cyp; Short=SRcyp; AltName: Full=Cyclophilin G; AltName: Full=Rotamase G; FUNCTION: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. May be implicated in the folding, transport, and assembly of proteins. May play an important role in the regulation of pre-mRNA splicing. CATALYTIC ACTIVITY: Peptidylproline (omega=180) = peptidylproline (omega=0). ENZYME REGULATION: Cyclosporin A (CsA)-sensitive. SUBUNIT: Interacts with CLK1, PNN and with the phosphorylated C- terminal domain of RNA polymerase II. SUBCELLULAR LOCATION: Nucleus matrix. Nucleus speckle. Note=Colocalizes with RNA splicing factors at nuclear speckles. TISSUE SPECIFICITY: Ubiquitous. DOMAIN: The RS domain is required for the interaction with the phosphorylated C-terminal domain of RNA polymerase II. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Contains 1 PPIase cyclophilin-type domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q13427
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
