Human Gene METTL5 (ENST00000260953.10) from GENCODE V44
  Description: Homo sapiens methyltransferase like 5 (METTL5), transcript variant 1, mRNA. (from RefSeq NM_014168)
Gencode Transcript: ENST00000260953.10
Gencode Gene: ENSG00000138382.15
Transcript (Including UTRs)
   Position: hg38 chr2:169,811,757-169,824,905 Size: 13,149 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr2:169,811,820-169,824,597 Size: 12,778 Coding Exon Count: 7 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr2:169,811,757-169,824,905)mRNA (may differ from genome)Protein (209 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGImyGene2
neXtProtOMIMPubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: METL5_HUMAN
DESCRIPTION: RecName: Full=Methyltransferase-like protein 5; EC=2.1.1.-;
FUNCTION: Probable methyltransferase (By similarity).
SIMILARITY: Belongs to the methyltransferase superfamily. PrmA family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: METTL5
Diseases sorted by gene-association score: epilepsy, familial temporal lobe, 4 (4)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 45.41 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 1106.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -129.70308-0.421 Picture PostScript Text
3' UTR -3.8063-0.060 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002052 - DNA_methylase_N6_adenine_CS
IPR007848 - Small_mtfrase_dom

Pfam Domains:
PF05175 - Methyltransferase small domain

ModBase Predicted Comparative 3D Structure on Q9NRN9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity

Biological Process:
GO:0032259 methylation


-  Descriptions from all associated GenBank mRNAs
  AF161482 - Homo sapiens HSPC133 mRNA, complete cds.
BC000921 - Homo sapiens methyltransferase like 5, mRNA (cDNA clone MGC:4937 IMAGE:3445582), complete cds.
AF201938 - Homo sapiens DC3 (DC3) mRNA, complete cds.
AK001321 - Homo sapiens cDNA FLJ10459 fis, clone NT2RP1001466.
BC093014 - Homo sapiens methyltransferase like 5, mRNA (cDNA clone MGC:110876 IMAGE:4799279), complete cds.
KJ898711 - Synthetic construct Homo sapiens clone ccsbBroadEn_08105 METTL5 gene, encodes complete protein.
AB590947 - Synthetic construct DNA, clone: pFN21AE1705, Homo sapiens METTL5 gene for methyltransferase like 5, without stop codon, in Flexi system.
JD370804 - Sequence 351828 from Patent EP1572962.
JD182346 - Sequence 163370 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: D3DPC9, DC3, ENST00000260953.1, ENST00000260953.2, ENST00000260953.3, ENST00000260953.4, ENST00000260953.5, ENST00000260953.6, ENST00000260953.7, ENST00000260953.8, ENST00000260953.9, HSPC133, METL5_HUMAN, NM_014168, Q9NRN9, Q9NVX1, uc002ufn.1, uc002ufn.2, uc002ufn.3, uc002ufn.4, uc002ufn.5
UCSC ID: ENST00000260953.10
RefSeq Accession: NM_014168
Protein: Q9NRN9 (aka METL5_HUMAN or MTL4_HUMAN)
CCDS: CCDS33320.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.