Human Gene STRADB (ENST00000194530.8) from GENCODE V44
Description: Homo sapiens STE20 related adaptor beta (STRADB), transcript variant 1, mRNA. (from RefSeq NM_018571) RefSeq Summary (NM_018571): This gene encodes a protein that belongs to the serine/threonine protein kinase STE20 subfamily. One of the active site residues in the protein kinase domain of this protein is altered, and it is thus a pseudokinase. This protein is a component of a complex involved in the activation of serine/threonine kinase 11, a master kinase that regulates cell polarity and energy-generating metabolism. This complex regulates the relocation of this kinase from the nucleus to the cytoplasm, and it is essential for G1 cell cycle arrest mediated by this kinase. The protein encoded by this gene can also interact with the X chromosome-linked inhibitor of apoptosis protein, and this interaction enhances the anti-apoptotic activity of this protein via the JNK1 signal transduction pathway. Two pseudogenes, located on chromosomes 1 and 7, have been found for this gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]. Gencode Transcript: ENST00000194530.8 Gencode Gene: ENSG00000082146.13 Transcript (Including UTRs) Position: hg38 chr2:201,451,740-201,480,846 Size: 29,107 Total Exon Count: 12 Strand: + Coding Region Position: hg38 chr2:201,454,841-201,480,175 Size: 25,335 Coding Exon Count: 11
ID:STRAB_HUMAN DESCRIPTION: RecName: Full=STE20-related kinase adapter protein beta; Short=STRAD beta; AltName: Full=Amyotrophic lateral sclerosis 2 chromosomal region candidate gene 2 protein; AltName: Full=CALS-21; AltName: Full=ILP-interacting protein; AltName: Full=Pseudokinase ALS2CR2; FUNCTION: Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity). SUBUNIT: Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. Interacts with BIRC4/XIAP. These two proteins are likely to coexist in a complex with TAK1, TRAF6, TAB1 and TAB2. INTERACTION: Q9Y376:CAB39; NbExp=5; IntAct=EBI-306893, EBI-306905; Q15831:STK11; NbExp=6; IntAct=EBI-306893, EBI-306838; SUBCELLULAR LOCATION: Nucleus. Cytoplasm. TISSUE SPECIFICITY: Highly expressed in heart, skeletal muscle, testis, liver and colon. DOMAIN: The protein kinase domain is predicted to be catalytically inactive. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain. CAUTION: Ser-184 is present instead of the conserved Asp which is expected to be an active site residue.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9C0K7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0000902 cell morphogenesis GO:0006611 protein export from nucleus GO:0007049 cell cycle GO:0007050 cell cycle arrest GO:0007346 regulation of mitotic cell cycle GO:0031098 stress-activated protein kinase signaling cascade GO:0032147 activation of protein kinase activity GO:0042981 regulation of apoptotic process GO:2001240 negative regulation of extrinsic apoptotic signaling pathway in absence of ligand GO:0006468 protein phosphorylation
AK027637 - Homo sapiens cDNA FLJ14731 fis, clone NT2RP3001938, weakly similar to SPORULATION-SPECIFIC PROTEIN 1 (EC 2.7.1.-). AK290457 - Homo sapiens cDNA FLJ77706 complete cds, highly similar to Homo sapiens amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2), mRNA. BC008302 - Homo sapiens STE20-related kinase adaptor beta, mRNA (cDNA clone MGC:15130 IMAGE:3546243), complete cds. AY093697 - Homo sapiens ILP-interacting protein ILPIPA (ILPIPA) mRNA, complete cds. AB038950 - Homo sapiens ALS2CR2 mRNA for amyotrophic lateral sclerosis 2, candidate 2, complete cds. BC090871 - Homo sapiens STE20-related kinase adaptor beta, mRNA (cDNA clone MGC:102916 IMAGE:30530122), complete cds. JD301540 - Sequence 282564 from Patent EP1572962. JD327583 - Sequence 308607 from Patent EP1572962. CU678911 - Synthetic construct Homo sapiens gateway clone IMAGE:100019312 5' read ALS2CR2 mRNA. AB590651 - Synthetic construct DNA, clone: pFN21AB6641, Homo sapiens STRADB gene for STE20-related kinase adaptor beta, without stop codon, in Flexi system. DQ896519 - Synthetic construct Homo sapiens clone IMAGE:100010979; FLH195119.01L; RZPDo839A1183D amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2) gene, encodes complete protein. DQ896865 - Synthetic construct Homo sapiens clone IMAGE:100011325; FLH195120.01L; RZPDo839B1183D amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2) gene, encodes complete protein. EU176785 - Synthetic construct Homo sapiens clone IMAGE:100011545; FLH195121.01L; RZPDo839C1183D amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2) gene, encodes complete protein. EU176786 - Synthetic construct Homo sapiens clone IMAGE:100011546; FLH195122.01L; RZPDo839D1183D amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2) gene, encodes complete protein. KJ899140 - Synthetic construct Homo sapiens clone ccsbBroadEn_08534 STRADB gene, encodes complete protein. DQ893688 - Synthetic construct clone IMAGE:100006318; FLH195123.01X; RZPDo839E1183D amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2) gene, encodes complete protein. DQ893689 - Synthetic construct clone IMAGE:100006319; FLH195124.01X; RZPDo839F1183D amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 2 (ALS2CR2) gene, encodes complete protein. AF116618 - Homo sapiens PRO1038 mRNA, complete cds. AK024720 - Homo sapiens cDNA: FLJ21067 fis, clone CAS01459, highly similar to AF116618 Homo sapiens PRO1038 mRNA. JD324598 - Sequence 305622 from Patent EP1572962. JD090133 - Sequence 71157 from Patent EP1572962. JD263820 - Sequence 244844 from Patent EP1572962. JD526041 - Sequence 507065 from Patent EP1572962. JD431944 - Sequence 412968 from Patent EP1572962. JD310985 - Sequence 292009 from Patent EP1572962. JD314042 - Sequence 295066 from Patent EP1572962. JD362477 - Sequence 343501 from Patent EP1572962. JD239211 - Sequence 220235 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9C0K7 (Reactome details) participates in the following event(s):
R-HSA-380942 LKB1 forms a trimeric complex with STRAD and MO25 R-HSA-200421 Activation of cytosolic AMPK by phosphorylation R-HSA-380972 Energy dependent regulation of mTOR by LKB1-AMPK R-HSA-165159 mTOR signalling R-HSA-162582 Signal Transduction
US Server
