Human Gene WDFY1 (ENST00000233055.9) from GENCODE V44
Description: Homo sapiens WD repeat and FYVE domain containing 1 (WDFY1), mRNA. (from RefSeq NM_020830) RefSeq Summary (NM_020830): The protein encoded by this gene is a phosphatidylinositol 3-phosphate binding protein, which contains a FYVE zinc finger domain and multiple WD-40 repeat domains. When exogenously expressed, it localizes to early endosomes. Mutagenesis analysis demonstrates that this endosomal localization is mediated by the FYVE domain. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000233055.9 Gencode Gene: ENSG00000085449.15 Transcript (Including UTRs) Position: hg38 chr2:223,875,348-223,945,335 Size: 69,988 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr2:223,878,671-223,945,284 Size: 66,614 Coding Exon Count: 12
ID:WDFY1_HUMAN DESCRIPTION: RecName: Full=WD repeat and FYVE domain-containing protein 1; AltName: Full=FENS-1; AltName: Full=Phosphoinositide-binding protein 1; AltName: Full=WD40- and FYVE domain-containing protein 1; AltName: Full=Zinc finger FYVE domain-containing protein 17; SUBUNIT: Binds PtdIns3P in vitro with high specificity over other phosphoinositides. SUBCELLULAR LOCATION: Early endosome. DOMAIN: The FYVE-type zinc finger domain mediates interactions with phosphatidylinositol 3-phosphate in membranes of early endosomes and penetrates bilayers. The FYVE domain insertion into PtdIns(3)P-enriched membranes is substantially increased in acidic conditions. SIMILARITY: Contains 1 FYVE-type zinc finger. SIMILARITY: Contains 7 WD repeats. SEQUENCE CAUTION: Sequence=BAA92673.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IWB7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
