Human Gene TRAF3IP1 (ENST00000373327.5) from GENCODE V44
Description: Homo sapiens TRAF3 interacting protein 1 (TRAF3IP1), transcript variant 1, mRNA. (from RefSeq NM_015650) RefSeq Summary (NM_015650): The protein encoded by this gene interacts with TNF receptor-associated factor 3, tethering it to cytoskeletal microtubules. The encoded protein is also an inhibitor of the innate type I IFN response. Defects in this gene are a cause of Senior-Loken syndrome 9. [provided by RefSeq, Mar 2017]. Gencode Transcript: ENST00000373327.5 Gencode Gene: ENSG00000204104.12 Transcript (Including UTRs) Position: hg38 chr2:238,320,518-238,400,897 Size: 80,380 Total Exon Count: 17 Strand: + Coding Region Position: hg38 chr2:238,320,663-238,398,919 Size: 78,257 Coding Exon Count: 17
ID:MIPT3_HUMAN DESCRIPTION: RecName: Full=TRAF3-interacting protein 1; AltName: Full=Interleukin-13 receptor alpha 1-binding protein 1; AltName: Full=Microtubule-interacting protein associated with TRAF3; Short=MIP-T3; FUNCTION: Plays an inhibitory role on IL13 signaling by binding to IL13RA1. Involved in suppression of IL13-induced STAT6 phosphorylation, transcriptional activity and DNA-binding. Recruits TRAF3 and DISC1 to the microtubules. SUBUNIT: Component of IFT complex B composed of IFT88, IFT57, TRAF3IP1, IFT52, IFT27, HSPB11 and IFT20 (By similarity). Interacts with IL13RA1. Binds to microtubules, TRAF3 and DISC1. INTERACTION: Q9NRI5:DISC1; NbExp=10; IntAct=EBI-928811, EBI-529989; P78552:IL13RA1; NbExp=3; IntAct=EBI-928811, EBI-1391535; Q13114:TRAF3; NbExp=8; IntAct=EBI-928811, EBI-357631; SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton. Note=Microtubules. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the TRAF3IP1 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8TDR0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001738 morphogenesis of a polarized epithelium GO:0001822 kidney development GO:0001933 negative regulation of protein phosphorylation GO:0021532 neural tube patterning GO:0030030 cell projection organization GO:0031076 embryonic camera-type eye development GO:0031333 negative regulation of protein complex assembly GO:0032480 negative regulation of type I interferon production GO:0032688 negative regulation of interferon-beta production GO:0035050 embryonic heart tube development GO:0035735 intraciliary transport involved in cilium assembly GO:0036342 post-anal tail morphogenesis GO:0042073 intraciliary transport GO:0042733 embryonic digit morphogenesis GO:0050687 negative regulation of defense response to virus GO:0060271 cilium assembly GO:0070507 regulation of microtubule cytoskeleton organization GO:1901621 negative regulation of smoothened signaling pathway involved in dorsal/ventral neural tube patterning
US Server
