Human Gene STK25 (ENST00000316586.9) from GENCODE V44
Description: Homo sapiens serine/threonine kinase 25 (STK25), transcript variant 4, mRNA. (from RefSeq NM_006374) RefSeq Summary (NM_001271977): This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]. Gencode Transcript: ENST00000316586.9 Gencode Gene: ENSG00000115694.15 Transcript (Including UTRs) Position: hg38 chr2:241,492,670-241,508,584 Size: 15,915 Total Exon Count: 12 Strand: - Coding Region Position: hg38 chr2:241,495,662-241,508,035 Size: 12,374 Coding Exon Count: 11
ID:STK25_HUMAN DESCRIPTION: RecName: Full=Serine/threonine-protein kinase 25; EC=2.7.11.1; AltName: Full=Ste20-like kinase; AltName: Full=Sterile 20/oxidant stress-response kinase 1; Short=SOK-1; Short=Ste20/oxidant stress response kinase 1; FUNCTION: Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. CATALYTIC ACTIVITY: ATP + a protein = ADP + a phosphoprotein. COFACTOR: Magnesium. ENZYME REGULATION: Interaction with Golgi matrix protein GOLGA2 leads to autophosphorylation on Thr-174, possibly as a consequence of stabilization of dimer formation. The C-terminal non-catalytic region inhibits the kinase activity. SUBUNIT: Homodimer. INTERACTION: Q62839:Golga2 (xeno); NbExp=2; IntAct=EBI-618295, EBI-618335; Q9BUL8:PDCD10; NbExp=7; IntAct=EBI-618295, EBI-740195; O43815:STRN; NbExp=2; IntAct=EBI-618295, EBI-1046642; P63104:YWHAZ; NbExp=2; IntAct=EBI-618295, EBI-347088; SUBCELLULAR LOCATION: Cytoplasm. Golgi apparatus. Note=Localizes to the Golgi apparatus. TISSUE SPECIFICITY: Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily. SIMILARITY: Contains 1 protein kinase domain. WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/stk25/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00506
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.