Human Gene SIRPB1 (ENST00000381603.7) from GENCODE V44
Description: Homo sapiens signal regulatory protein beta 1 (SIRPB1), transcript variant 2, mRNA. (from RefSeq NM_001083910) RefSeq Summary (NM_001083910): The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]. Gencode Transcript: ENST00000381603.7 Gencode Gene: ENSG00000101307.16 Transcript (Including UTRs) Position: hg38 chr20:1,564,383-1,619,996 Size: 55,614 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr20:1,566,155-1,619,944 Size: 53,790 Coding Exon Count: 3
ID:SIRB1_HUMAN DESCRIPTION: RecName: Full=Signal-regulatory protein beta-1; Short=SIRP-beta-1; AltName: Full=CD172 antigen-like family member B; AltName: CD_antigen=CD172b; Flags: Precursor; FUNCTION: Immunoglobulin-like cell surface receptor involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. Participates also in the recruitment of tyrosine kinase SYK. SUBUNIT: Homodimer; disulfide-linked. Interacts with TYROBP. This interaction results in the recruitment of SYK. INTERACTION: O43914:TYROBP; NbExp=4; IntAct=EBI-2615458, EBI-2214794; SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. TISSUE SPECIFICITY: Detected in monocytes and dendritic cells. PTM: N-glycosylated. SIMILARITY: Contains 2 Ig-like C1-type (immunoglobulin-like) domains. SIMILARITY: Contains 1 Ig-like V-type (immunoglobulin-like) domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O00241
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
US Server
