Human Gene SLC35C2 (ENST00000543605.5) from GENCODE V44
Description: Homo sapiens solute carrier family 35 member C2 (SLC35C2), transcript variant 3, mRNA. (from RefSeq NM_173073) RefSeq Summary (NM_173073): This gene encodes a member of the triose-phosphate transporter protein family. This gene is regulated by oxygen tension, is induced in hypoxic trophoblast cells, and is overexpressed in ovarian cancer. Alternative splicing results in multiple transcript variants. A pseudogene of this gene has been defined on the X chromosome. [provided by RefSeq, Jul 2013]. Gencode Transcript: ENST00000543605.5 Gencode Gene: ENSG00000080189.15 Transcript (Including UTRs) Position: hg38 chr20:46,345,980-46,364,404 Size: 18,425 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr20:46,350,394-46,358,506 Size: 8,113 Coding Exon Count: 9
ID:S35C2_HUMAN DESCRIPTION: RecName: Full=Solute carrier family 35 member C2; AltName: Full=Ovarian cancer-overexpressed gene 1 protein; FUNCTION: May play an important role in the cellular response to tissue hypoxia. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). TISSUE SPECIFICITY: Ubiquitously expressed although the level of expression is tissue dependent. Overexpressed in ovarian cancer. INDUCTION: In hypoxic trophoblast cells. SIMILARITY: Belongs to the TPT transporter family. SLC35C subfamily. SEQUENCE CAUTION: Sequence=AAD27724.1; Type=Frameshift; Positions=168, 211, 305;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03151 - Triose-phosphate Transporter family
ModBase Predicted Comparative 3D Structure on Q9NQQ7
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
