Human Gene ZFP64 (ENST00000346617.8) from GENCODE V44
  Description: Homo sapiens ZFP64 zinc finger protein (ZFP64), transcript variant 2, mRNA. (from RefSeq NM_022088)
Gencode Transcript: ENST00000346617.8
Gencode Gene: ENSG00000020256.20
Transcript (Including UTRs)
   Position: hg38 chr20:52,151,278-52,191,760 Size: 40,483 Total Exon Count: 5 Strand: -
Coding Region
   Position: hg38 chr20:52,152,146-52,191,636 Size: 39,491 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr20:52,151,278-52,191,760)mRNA (may differ from genome)Protein (627 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMGIneXtProtOMIMPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZF64B_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 64 homolog, isoforms 3 and 4; Short=Zfp-64; AltName: Full=Zinc finger protein 338;
FUNCTION: May be involved in transcriptional regulation.
SUBCELLULAR LOCATION: Nucleus (Probable).
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 13 C2H2-type zinc fingers.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.38 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 89.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -58.00124-0.468 Picture PostScript Text
3' UTR -236.00868-0.272 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

ModBase Predicted Comparative 3D Structure on Q9NTW7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl   
Protein SequenceProtein SequenceProtein Sequence   
AlignmentAlignmentAlignment   

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  AK222712 - Homo sapiens mRNA for zinc finger protein 64 isoform d variant, clone: COL01868.
BC021087 - Homo sapiens zinc finger protein 64 homolog (mouse), mRNA (cDNA clone IMAGE:2966379).
BT009760 - Homo sapiens zinc finger protein 64 homolog (mouse) mRNA, complete cds.
BC012759 - Homo sapiens zinc finger protein 64 homolog (mouse), mRNA (cDNA clone MGC:16165 IMAGE:3634346), complete cds.
BC041622 - Homo sapiens zinc finger protein 64 homolog (mouse), mRNA (cDNA clone MGC:52187 IMAGE:3633938), complete cds.
AK090547 - Homo sapiens cDNA FLJ33228 fis, clone ASTRO2001122, highly similar to Zinc finger protein 64, isoforms 1 and 2.
AK001596 - Homo sapiens cDNA FLJ10734 fis, clone NT2RP3001398, weakly similar to TRANSCRIPTIONAL REPRESSOR CTCF.
BC031524 - Homo sapiens cDNA clone IMAGE:3924519, containing frame-shift errors.
AK001744 - Homo sapiens cDNA FLJ10882 fis, clone NT2RP4001938, weakly similar to TRANSCRIPTIONAL REPRESSOR CTCF.
KJ899179 - Synthetic construct Homo sapiens clone ccsbBroadEn_08573 ZFP64 gene, encodes complete protein.
AB527686 - Synthetic construct DNA, clone: pF1KB6248, Homo sapiens ZFP64 gene for zinc finger protein 64 homolog, without stop codon, in Flexi system.
AK024671 - Homo sapiens cDNA: FLJ21018 fis, clone CAE06021.
JD053637 - Sequence 34661 from Patent EP1572962.
JD065879 - Sequence 46903 from Patent EP1572962.
JD237811 - Sequence 218835 from Patent EP1572962.
JD210847 - Sequence 191871 from Patent EP1572962.
JD213186 - Sequence 194210 from Patent EP1572962.
JD542955 - Sequence 523979 from Patent EP1572962.
JD560974 - Sequence 541998 from Patent EP1572962.
JD165264 - Sequence 146288 from Patent EP1572962.
JD262109 - Sequence 243133 from Patent EP1572962.
JD087102 - Sequence 68126 from Patent EP1572962.
JD213185 - Sequence 194209 from Patent EP1572962.
JD213188 - Sequence 194212 from Patent EP1572962.
JD542080 - Sequence 523104 from Patent EP1572962.
JD297586 - Sequence 278610 from Patent EP1572962.
JD153725 - Sequence 134749 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: A2A2N4, ENST00000346617.1, ENST00000346617.2, ENST00000346617.3, ENST00000346617.4, ENST00000346617.5, ENST00000346617.6, ENST00000346617.7, NM_022088, Q53H69, Q53XQ1, Q5JWM0, Q8WU98, Q9H9P1, Q9NTW7, uc002xwn.1, uc002xwn.2, uc002xwn.3, uc002xwn.4, ZF64B_HUMAN, ZNF338
UCSC ID: ENST00000346617.8
RefSeq Accession: NM_022088
Protein: Q9NTW7 (aka ZF64B_HUMAN or Z64B_HUMAN)
CCDS: CCDS13441.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.