Human Gene SLC2A4RG (ENST00000266077.5) from GENCODE V44
Description: Homo sapiens SLC2A4 regulator (SLC2A4RG), mRNA. (from RefSeq NM_020062) RefSeq Summary (NM_020062): The protein encoded by this gene is a nuclear transcription factor involved in the activation of the solute carrier family 2 member 4 gene. The encoded protein interacts with another transcription factor, myocyte enhancer factor 2, to activate transcription of this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000266077.5 Gencode Gene: ENSG00000125520.14 Transcript (Including UTRs) Position: hg38 chr20:63,739,776-63,744,050 Size: 4,275 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr20:63,739,913-63,742,990 Size: 3,078 Coding Exon Count: 8
ID:S2A4R_HUMAN DESCRIPTION: RecName: Full=SLC2A4 regulator; AltName: Full=GLUT4 enhancer factor; Short=GEF; AltName: Full=Huntington disease gene regulatory region-binding protein 1; Short=HDBP-1; FUNCTION: Transcription factor involved in SLC2A4 and HD gene transactivation. Binds to the consensus sequence 5'-GCCGGCG-3'. SUBUNIT: Interacts with MEF2A. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus. TISSUE SPECIFICITY: According to PubMed:14630949, expressed in heart, skeletal muscle, liver, kidney and pancreas; undetectable in lung, placenta or brain. According to PubMed:14625278, ubiquitously expressed, with lowest expression in brain and ileum. SIMILARITY: Contains 1 C2H2-type zinc finger. SEQUENCE CAUTION: Sequence=AAH17446.1; Type=Erroneous initiation; Sequence=BAD29732.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NR83
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Mouse
Rat
Zebrafish
D. melanogaster
C. elegans
S. cerevisiae
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
No ortholog
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0001158 enhancer sequence-specific DNA binding GO:0003676 nucleic acid binding GO:0003677 DNA binding GO:0003700 transcription factor activity, sequence-specific DNA binding GO:0046872 metal ion binding
Biological Process: GO:0006351 transcription, DNA-templated GO:0006355 regulation of transcription, DNA-templated GO:0006357 regulation of transcription from RNA polymerase II promoter
US Server
