Human Gene POTED (ENST00000299443.6) from GENCODE V44
  Description: Homo sapiens POTE ankyrin domain family member D (POTED), mRNA. (from RefSeq NM_174981)
Gencode Transcript: ENST00000299443.6
Gencode Gene: ENSG00000166351.11
Transcript (Including UTRs)
   Position: hg38 chr21:13,609,777-13,645,823 Size: 36,047 Total Exon Count: 11 Strand: +
Coding Region
   Position: hg38 chr21:13,610,229-13,641,566 Size: 31,338 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:13,609,777-13,645,823)mRNA (may differ from genome)Protein (584 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDMalacardsMGIneXtProtOMIM
PubMedUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: POTED_HUMAN
DESCRIPTION: RecName: Full=POTE ankyrin domain family member D; AltName: Full=ANKRD26-like family B member 3; AltName: Full=Ankyrin repeat domain-containing protein 21; AltName: Full=Prostate, ovary, testis-expressed protein; Short=Protein POTE;
SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein.
TISSUE SPECIFICITY: Expressed in prostate, ovary, testis, placenta and prostate cancer cell lines. Localizes to basal and terminal prostate epithelial cells.
SIMILARITY: Belongs to the POTE family.
SIMILARITY: Contains 6 ANK repeats.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: POTED
Diseases sorted by gene-association score: holoprosencephaly 3 (2)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene
  • C049584 2-amino-1-methyl-6-phenylimidazo(4,5-b)pyridine
  • C036990 2-amino-3,8-dimethylimidazo(4,5-f)quinoxaline
  • D019327 Copper Sulfate
  • C006253 pirinixic acid

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 4.18 RPKM in Testis
Total median expression: 4.18 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -180.70452-0.400 Picture PostScript Text
3' UTR -1459.704257-0.343 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002110 - Ankyrin_rpt
IPR020683 - Ankyrin_rpt-contain_dom

Pfam Domains:
PF12796 - Ankyrin repeats (3 copies)

ModBase Predicted Comparative 3D Structure on Q86YR6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserNo orthologNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGI     
Protein Sequence     
Alignment     

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Cellular Component:
GO:0005886 plasma membrane
GO:0016020 membrane


-  Descriptions from all associated GenBank mRNAs
  AY172978 - Homo sapiens POTE mRNA, complete cds.
BC166701 - Synthetic construct Homo sapiens clone IMAGE:100066427, MGC:195564 POTE ankyrin domain family, member D (POTED) mRNA, encodes complete protein.
JD315124 - Sequence 296148 from Patent EP1572962.
JD289498 - Sequence 270522 from Patent EP1572962.
HZ481095 - JP 2015535430-A/1601: TERMINALLY MODIFIED RNA.
HZ791026 - JP 2016504050-A/2771: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
JC513758 - Sequence 4011 from Patent WO2014113089.
LQ071346 - Sequence 1670 from Patent EP2964234.
MA644847 - JP 2017113010-A/2771: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.
MA732731 - JP 2017140048-A/1601: TERMINALLY MODIFIED RNA.
MA801900 - JP 2018183181-A/2771: SIGNAL-SENSOR POLYNUCLEOTIDES FOR THE ALTERATION OF CELLULAR PHENOTYPES.

-  Other Names for This Gene
  Alternate Gene Symbols: A26B3, ANKRD21, C9JCF7, ENST00000299443.1, ENST00000299443.2, ENST00000299443.3, ENST00000299443.4, ENST00000299443.5, NM_174981, POTE, POTED_HUMAN, Q86YR6, uc002yjb.1, uc002yjb.2
UCSC ID: ENST00000299443.6
RefSeq Accession: NM_174981
Protein: Q86YR6 (aka POTED_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.