Human Gene C21orf91 (ENST00000400558.7) from GENCODE V44
Description: Homo sapiens chromosome 21 open reading frame 91 (C21orf91), transcript variant 3, mRNA. (from RefSeq NM_001100421)
Gencode Transcript: ENST00000400558.7
Gencode Gene: ENSG00000154642.11
Transcript (Including UTRs)
Position: hg38 chr21:17,793,247-17,819,386 Size: 26,140 Total Exon Count: 4 Strand: -
Coding Region
Position: hg38 chr21:17,793,580-17,818,318 Size: 24,739 Coding Exon Count: 3
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: EURL_HUMAN
DESCRIPTION: RecName: Full=Protein EURL homolog;
SIMILARITY: Belongs to the EURL family.SEQUENCE CAUTION: Sequence=BAB14691.1; Type=Erroneous termination; Positions=164; Note=Translated as Gln;
Primer design for this transcript
MalaCards Disease Associations
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR009704 - EURL_prot
Pfam Domains: PF06937 - EURL protein
ModBase Predicted Comparative 3D Structure on Q9NYK6
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Biological Process: GO:0007399 nervous system development
GO:0021895 cerebral cortex neuron differentiation
GO:0030154 cell differentiation
GO:0060999 positive regulation of dendritic spine development
Descriptions from all associated GenBank mRNAs
CR749496 - Homo sapiens mRNA; cDNA DKFZp781D1223 (from clone DKFZp781D1223).LF385139 - JP 2014500723-A/192642: Polycomb-Associated Non-Coding RNAs.MA620716 - JP 2018138019-A/192642: Polycomb-Associated Non-Coding RNAs.AK023825 - Homo sapiens cDNA FLJ13763 fis, clone PLACE4000089.BC015468 - Homo sapiens chromosome 21 open reading frame 91, mRNA (cDNA clone MGC:8771 IMAGE:3916462), complete cds.AK225123 - Homo sapiens mRNA for EURL protein homolog, clone: CBL04328.AF239726 - Homo sapiens chromosome 21 unknown mRNA.LF339710 - JP 2014500723-A/147213: Polycomb-Associated Non-Coding RNAs.MA575287 - JP 2018138019-A/147213: Polycomb-Associated Non-Coding RNAs.KJ898968 - Synthetic construct Homo sapiens clone ccsbBroadEn_08362 C21orf91 gene, encodes complete protein.AB463520 - Synthetic construct DNA, clone: pF1KB6360, Homo sapiens C21orf91 gene for chromosome 21 open reading frame 91, without stop codon, in Flexi system.AK314471 - Homo sapiens cDNA, FLJ95275.CR457317 - Homo sapiens full open reading frame cDNA clone RZPDo834G099D for gene C21orf91, chromosome 21 open reading frame 91; complete cds, incl. stopcodon.
Other Names for This Gene
Alternate Gene Symbols: B2RB30, C21orf14, C21orf38, C21orf7, ENST00000400558.1, ENST00000400558.2, ENST00000400558.3, ENST00000400558.4, ENST00000400558.5, ENST00000400558.6, EURL, EURL_HUMAN, NM_001100421, Q96BK9, Q9H8C6, Q9NYK6, uc002ykp.1, uc002ykp.2, uc002ykp.3, uc002ykp.4, uc002ykp.5, YG81UCSC ID: ENST00000400558.7RefSeq Accession: NM_001100421
Protein: Q9NYK6
(aka EURL_HUMAN)
CCDS: CCDS42909.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.