Human Gene C21orf91 (ENST00000400558.7) from GENCODE V44
  Description: Homo sapiens chromosome 21 open reading frame 91 (C21orf91), transcript variant 3, mRNA. (from RefSeq NM_001100421)
Gencode Transcript: ENST00000400558.7
Gencode Gene: ENSG00000154642.11
Transcript (Including UTRs)
   Position: hg38 chr21:17,793,247-17,819,386 Size: 26,140 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr21:17,793,580-17,818,318 Size: 24,739 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr21:17,793,247-17,819,386)mRNA (may differ from genome)Protein (221 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCLynxMalacardsMGIneXtProtPubMed
UniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: EURL_HUMAN
DESCRIPTION: RecName: Full=Protein EURL homolog;
SIMILARITY: Belongs to the EURL family.
SEQUENCE CAUTION: Sequence=BAB14691.1; Type=Erroneous termination; Positions=164; Note=Translated as Gln;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: C21orf91
Diseases sorted by gene-association score: staphyloenterotoxemia (7), listeriosis (5)

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.67 RPKM in Testis
Total median expression: 114.52 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.5091-0.489 Picture PostScript Text
3' UTR -77.60333-0.233 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR009704 - EURL_prot

Pfam Domains:
PF06937 - EURL protein

ModBase Predicted Comparative 3D Structure on Q9NYK6
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Biological Process:
GO:0007399 nervous system development
GO:0021895 cerebral cortex neuron differentiation
GO:0030154 cell differentiation
GO:0060999 positive regulation of dendritic spine development


-  Descriptions from all associated GenBank mRNAs
  CR749496 - Homo sapiens mRNA; cDNA DKFZp781D1223 (from clone DKFZp781D1223).
LF385139 - JP 2014500723-A/192642: Polycomb-Associated Non-Coding RNAs.
MA620716 - JP 2018138019-A/192642: Polycomb-Associated Non-Coding RNAs.
AK023825 - Homo sapiens cDNA FLJ13763 fis, clone PLACE4000089.
BC015468 - Homo sapiens chromosome 21 open reading frame 91, mRNA (cDNA clone MGC:8771 IMAGE:3916462), complete cds.
AK225123 - Homo sapiens mRNA for EURL protein homolog, clone: CBL04328.
AF239726 - Homo sapiens chromosome 21 unknown mRNA.
LF339710 - JP 2014500723-A/147213: Polycomb-Associated Non-Coding RNAs.
MA575287 - JP 2018138019-A/147213: Polycomb-Associated Non-Coding RNAs.
KJ898968 - Synthetic construct Homo sapiens clone ccsbBroadEn_08362 C21orf91 gene, encodes complete protein.
AB463520 - Synthetic construct DNA, clone: pF1KB6360, Homo sapiens C21orf91 gene for chromosome 21 open reading frame 91, without stop codon, in Flexi system.
AK314471 - Homo sapiens cDNA, FLJ95275.
CR457317 - Homo sapiens full open reading frame cDNA clone RZPDo834G099D for gene C21orf91, chromosome 21 open reading frame 91; complete cds, incl. stopcodon.

-  Other Names for This Gene
  Alternate Gene Symbols: B2RB30, C21orf14, C21orf38, C21orf7, ENST00000400558.1, ENST00000400558.2, ENST00000400558.3, ENST00000400558.4, ENST00000400558.5, ENST00000400558.6, EURL, EURL_HUMAN, NM_001100421, Q96BK9, Q9H8C6, Q9NYK6, uc002ykp.1, uc002ykp.2, uc002ykp.3, uc002ykp.4, uc002ykp.5, YG81
UCSC ID: ENST00000400558.7
RefSeq Accession: NM_001100421
Protein: Q9NYK6 (aka EURL_HUMAN)
CCDS: CCDS42909.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.