Human Gene N6AMT1 (ENST00000351429.7) from GENCODE V44
Description: Homo sapiens N-6 adenine-specific DNA methyltransferase 1 (N6AMT1), transcript variant 2, mRNA. (from RefSeq NM_182749) RefSeq Summary (NM_013240): This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing pf this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Jul 2014]. Gencode Transcript: ENST00000351429.7 Gencode Gene: ENSG00000156239.12 Transcript (Including UTRs) Position: hg38 chr21:28,872,191-28,885,371 Size: 13,181 Total Exon Count: 5 Strand: - Coding Region Position: hg38 chr21:28,876,385-28,885,345 Size: 8,961 Coding Exon Count: 5
ID:HEMK2_HUMAN DESCRIPTION: RecName: Full=HemK methyltransferase family member 2; EC=2.1.1.-; AltName: Full=M.HsaHemK2P; AltName: Full=N(6)-adenine-specific DNA methyltransferase 1; FUNCTION: Heterodimeric methyltransferase that catalyzes N5- methylation of ETF1 on 'Gln-185', using S-adenosyl L-methionine as methyl donor. ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated. May play a role in the modulation of arsenic-induced toxicity. May be involved in the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid. SUBUNIT: Heterodimer with TRMT112. TISSUE SPECIFICITY: Widely expressed, with highest expression in parathyroid and pituitary glands, followed by adrenal gland and kidney, and lowest expression in leukocytes and mammary gland. SIMILARITY: Belongs to the eukaryotic/archaeal PrmC-related family. CAUTION: Was originally (Ref.1) proposed to be a DNA methyltransferase, but was then shown to be a protein methyltransferase (PubMed:18539146).
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9Y5N5
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
