Human Gene UMODL1 (ENST00000400427.5) from GENCODE V44
Description: Homo sapiens uromodulin like 1 (UMODL1), transcript variant 3, mRNA. (from RefSeq NM_001199527)
Gencode Transcript: ENST00000400427.5
Gencode Gene: ENSG00000177398.19
Transcript (Including UTRs)
Position: hg38 chr21:42,062,959-42,142,995 Size: 80,037 Total Exon Count: 22 Strand: +
Coding Region
Position: hg38 chr21:42,076,145-42,137,620 Size: 61,476 Coding Exon Count: 20
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: UROL1_HUMAN
DESCRIPTION: RecName: Full=Uromodulin-like 1; AltName: Full=Olfactorin; Flags: Precursor;
SUBCELLULAR LOCATION: Cell membrane; Single-pass type I membrane protein.SUBCELLULAR LOCATION: Isoform 3: Cytoplasm.SUBCELLULAR LOCATION: Isoform 4: Cytoplasm.TISSUE SPECIFICITY: Isoform 4 is expressed at low level in kidney, testis and fetal thymus. Isoform 3 is expressed at low level in prostate, testis and fetal thymus.SIMILARITY: Contains 3 EGF-like domains.SIMILARITY: Contains 1 EMI domain.SIMILARITY: Contains 2 fibronectin type-III domains.SIMILARITY: Contains 2 SEA domains.SIMILARITY: Contains 1 WAP domain.SIMILARITY: Contains 1 ZP domain.SEQUENCE CAUTION: Sequence=BAC04211.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR000742 - EG-like_dom
IPR001881 - EGF-like_Ca-bd
IPR000152 - EGF-type_Asp/Asn_hydroxyl_site
IPR018097 - EGF_Ca-bd_CS
IPR011489 - EMI_domain
IPR003961 - Fibronectin_type3
IPR013783 - Ig-like_fold
IPR000082 - SEA
IPR008197 - Whey_acidic_protein_4-diS_core
IPR001507 - ZP_dom
Pfam Domains: PF07645 - Calcium-binding EGF domain
PF07546 - EMI domain
PF01390 - SEA domain
PF00095 - WAP-type (Whey Acidic Protein) 'four-disulfide core'
PF00100 - Zona pellucida-like domain
ModBase Predicted Comparative 3D Structure on Q5DID0
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
AB051810 - Homo sapiens UMODL1 mRNA for uromodulin-like protein, long form, complete cds.AB051811 - Homo sapiens UMODL1 mRNA for uromodulin-like protein, short form, complete cds.AB096965 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 1, partial cds.BC167790 - Synthetic construct Homo sapiens clone IMAGE:100068180, MGC:195797 uromodulin-like 1 (UMODL1) mRNA, encodes complete protein.AY771619 - Homo sapiens olfactorin long isoform precursor (UMODL1) mRNA, complete cds, alternatively spliced.AY771620 - Homo sapiens olfactorin short isoform precursor (UMODL1) mRNA, complete cds, alternatively spliced.AB096966 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 2, partial cds.AB096967 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 3, partial cds.AB096968 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 4, partial cds.AB096969 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 5, partial cds.AB096970 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 6, partial cds.AB096971 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 7, partial cds.CU687701 - Synthetic construct Homo sapiens gateway clone IMAGE:100021638 3' read C21orf128 mRNA.JD095366 - Sequence 76390 from Patent EP1572962.AB096972 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 8, partial cds.AK124223 - Homo sapiens cDNA FLJ42229 fis, clone THYMU3000028, weakly similar to Rat Tamm-Horsfall protein mRNA.AK093654 - Homo sapiens cDNA FLJ36335 fis, clone THYMU2006277.AX748245 - Sequence 1770 from Patent EP1308459.JD364776 - Sequence 345800 from Patent EP1572962.JD189140 - Sequence 170164 from Patent EP1572962.BC039531 - Homo sapiens uromodulin-like 1, mRNA (cDNA clone IMAGE:5742385), partial cds.AB096973 - Homo sapiens UMODL1 mRNA for uromodulin-like 1 protein variant 9, partial cds.JD361605 - Sequence 342629 from Patent EP1572962.JD385326 - Sequence 366350 from Patent EP1572962.JD420544 - Sequence 401568 from Patent EP1572962.JD227295 - Sequence 208319 from Patent EP1572962.JD078672 - Sequence 59696 from Patent EP1572962.JD521035 - Sequence 502059 from Patent EP1572962.JD205646 - Sequence 186670 from Patent EP1572962.JD462500 - Sequence 443524 from Patent EP1572962.JD142241 - Sequence 123265 from Patent EP1572962.JD172902 - Sequence 153926 from Patent EP1572962.JD364782 - Sequence 345806 from Patent EP1572962.JD274437 - Sequence 255461 from Patent EP1572962.JD358316 - Sequence 339340 from Patent EP1572962.JD349388 - Sequence 330412 from Patent EP1572962.JD078286 - Sequence 59310 from Patent EP1572962.JD289490 - Sequence 270514 from Patent EP1572962.JD239752 - Sequence 220776 from Patent EP1572962.JD046496 - Sequence 27520 from Patent EP1572962.
Other Names for This Gene
Alternate Gene Symbols: C9JCE6, ENST00000400427.1, ENST00000400427.2, ENST00000400427.3, ENST00000400427.4, NM_001199527, Q5DIC9, Q5DID0, Q6LA40, Q6LA41, Q8N216, uc002zae.1, UROL1_HUMANUCSC ID: ENST00000400427.5RefSeq Accession: NM_001199527
Protein: Q5DID0
(aka UROL1_HUMAN)
CCDS: CCDS56215.1 , CCDS42935.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.