Human Gene SLC19A1 (ENST00000380010.8) from GENCODE V44
Description: Homo sapiens solute carrier family 19 member 1 (SLC19A1), transcript variant 2, mRNA. (from RefSeq NM_001205206) RefSeq Summary (NM_001205206): The membrane protein encoded by this gene is a transporter of folate and is involved in the regulation of intracellular concentrations of folate. Three transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000380010.8 Gencode Gene: ENSG00000173638.19 Transcript (Including UTRs) Position: hg38 chr21:45,514,715-45,542,471 Size: 27,757 Total Exon Count: 6 Strand: - Coding Region Position: hg38 chr21:45,514,976-45,537,959 Size: 22,984 Coding Exon Count: 5
ID:S19A1_HUMAN DESCRIPTION: RecName: Full=Folate transporter 1; Short=FOLT; AltName: Full=Intestinal folate carrier 1; Short=IFC-1; AltName: Full=Placental folate transporter; AltName: Full=Reduced folate carrier protein; Short=RFC; AltName: Full=Solute carrier family 19 member 1; FUNCTION: Transporter for the intake of folate. Uptake of folate in human placental choriocarcinoma cells occurs by a novel mechanism called potocytosis which functionally couples three components, namely the folate receptor, the folate transporter, and a V-type H(+)-pump. SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Placenta, liver, and to a much smaller extent, in lung. PTM: Heavily glycosylated. SIMILARITY: Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P41440
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0015884 folic acid transport GO:0046655 folic acid metabolic process GO:0051180 vitamin transport GO:0051958 methotrexate transport GO:0098838 reduced folate transmembrane transport
AB209069 - Homo sapiens mRNA for solute carrier family 19 member 1 isoform b variant protein. AK310797 - Homo sapiens cDNA, FLJ17839. U17566 - Human 65 kDa hydrophobic protein mRNA, complete cds. U19720 - Human reduced folate carrier (RFC) mRNA, complete cds. BC003068 - Homo sapiens solute carrier family 19 (folate transporter), member 1, mRNA (cDNA clone MGC:2165 IMAGE:3509422), complete cds. JD079096 - Sequence 60120 from Patent EP1572962. JD237248 - Sequence 218272 from Patent EP1572962. BC128247 - Homo sapiens solute carrier family 19 (folate transporter), member 1, mRNA (cDNA clone IMAGE:40114770), partial cds. JD491266 - Sequence 472290 from Patent EP1572962. AF004354 - Homo sapiens folate carrier mRNA, complete cds. JD294892 - Sequence 275916 from Patent EP1572962. JD141467 - Sequence 122491 from Patent EP1572962. JD195958 - Sequence 176982 from Patent EP1572962. DQ891831 - Synthetic construct clone IMAGE:100004461; FLH180377.01X; RZPDo839B07134D solute carrier family 19 (folate transporter), member 1 (SLC19A1) gene, encodes complete protein. DQ895016 - Synthetic construct Homo sapiens clone IMAGE:100009476; FLH180373.01L; RZPDo839B07133D solute carrier family 19 (folate transporter), member 1 (SLC19A1) gene, encodes complete protein. JD487779 - Sequence 468803 from Patent EP1572962. JD104706 - Sequence 85730 from Patent EP1572962. JD471049 - Sequence 452073 from Patent EP1572962. JD538951 - Sequence 519975 from Patent EP1572962. JD090546 - Sequence 71570 from Patent EP1572962. U15939 - Human placental folate transporter (hFOLT1) mRNA, complete cds. AK303168 - Homo sapiens cDNA FLJ53257 complete cds, highly similar to Folate transporter 1. S78996 - RFC1=reduced folate carrier {coding region} [human, testis, mRNA Partial, 1776 nt]. AK313125 - Homo sapiens cDNA, FLJ93611, highly similar to Homo sapiens solute carrier family 19 (folate transporter), member 1 (SLC19A1), mRNA. AK307623 - Homo sapiens cDNA, FLJ97571. JD389089 - Sequence 370113 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein P41440 (Reactome details) participates in the following event(s):
R-HSA-200652 Extracellular 5-methyltetrahydrofolate import across the plasma membrane R-HSA-196757 Metabolism of folate and pterines R-HSA-196849 Metabolism of water-soluble vitamins and cofactors R-HSA-196854 Metabolism of vitamins and cofactors R-HSA-1430728 Metabolism
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