Human Gene MCM5 (ENST00000493076.5) from GENCODE V44
  Description: minichromosome maintenance complex component 5 (from HGNC MCM5)
RefSeq Summary (NM_006739): The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. [provided by RefSeq, Jul 2008].
Gencode Transcript: ENST00000493076.5
Gencode Gene: ENSG00000100297.16
Transcript (Including UTRs)
   Position: hg38 chr22:35,410,409-35,424,501 Size: 14,093 Total Exon Count: 9 Strand: +


Page IndexSequence and LinksPrimersMalaCardsCTDRNA-Seq Expression
Microarray ExpressionOther SpeciesmRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:35,410,409-35,424,501)mRNA (may differ from genome)No protein
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaBioGPS
EnsemblExonPrimerGencodeHGNCLynxMalacards
PubMedWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: MCM5
Diseases sorted by gene-association score: meier-gorlin syndrome 8* (950), melanoacanthoma (16)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 43.97 RPKM in Cells - EBV-transformed lymphocytes
Total median expression: 307.49 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Descriptions from all associated GenBank mRNAs
  LF208154 - JP 2014500723-A/15657: Polycomb-Associated Non-Coding RNAs.
MA443731 - JP 2018138019-A/15657: Polycomb-Associated Non-Coding RNAs.
AK301121 - Homo sapiens cDNA FLJ54759 complete cds, highly similar to DNA replication licensing factor MCM5.
AK223323 - Homo sapiens mRNA for minichromosome maintenance deficient protein 5 variant, clone: TMS07715.
D83986 - Homo sapiens mRNA for DNA replication licensing factor (huMCM5), complete cds.
AK291136 - Homo sapiens cDNA FLJ78580 complete cds, highly similar to Homo sapiens MCM5 minichromosome maintenance deficient 5, cell division cycle 46 (MCM5), mRNA.
AK130620 - Homo sapiens cDNA FLJ27110 fis, clone SPL05630, highly similar to DNA replication licensing factor MCM5.
AK298624 - Homo sapiens cDNA FLJ55743 complete cds, highly similar to DNA replication licensing factor MCM5.
AK312533 - Homo sapiens cDNA, FLJ92902, Homo sapiens MCM5 minichromosome maintenance deficient 5, celldivision cycle 46 (S. cerevisiae) (MCM5), mRNA.
AK122853 - Homo sapiens cDNA FLJ16474 fis, clone BRSSN2012254, highly similar to DNA replication licensing factor MCM5.
BC000142 - Homo sapiens minichromosome maintenance complex component 5, mRNA (cDNA clone MGC:5315 IMAGE:2900229), complete cds.
AK308343 - Homo sapiens cDNA, FLJ98291.
CR456517 - Homo sapiens MCM5 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.MCM5).
X74795 - H.sapiens P1-Cdc46 mRNA.
BC003656 - Homo sapiens minichromosome maintenance complex component 5, mRNA (cDNA clone MGC:4773 IMAGE:3542201), complete cds.
CU674060 - Synthetic construct Homo sapiens gateway clone IMAGE:100020045 5' read MCM5 mRNA.
CU678562 - Synthetic construct Homo sapiens gateway clone IMAGE:100017474 5' read MCM5 mRNA.
AB463121 - Synthetic construct DNA, clone: pF1KB4809, Homo sapiens MCM5 gene for minichromosome maintenance complex component 5, without stop codon, in Flexi system.
CU013405 - Homo sapiens MCM5, mRNA (cDNA clone IMAGE:100000278), complete cds, without stop codon, in Gateway system.
KJ897175 - Synthetic construct Homo sapiens clone ccsbBroadEn_06569 MCM5 gene, encodes complete protein.
KJ897176 - Synthetic construct Homo sapiens clone ccsbBroadEn_06570 MCM5 gene, encodes complete protein.
CU013117 - Homo sapiens MCM5, mRNA (cDNA clone IMAGE:100000374), complete cds, with stop codon, in Gateway system.
AB209612 - Homo sapiens mRNA for minichromosome maintenance deficient protein 5 variant protein.
LF373029 - JP 2014500723-A/180532: Polycomb-Associated Non-Coding RNAs.
MA608606 - JP 2018138019-A/180532: Polycomb-Associated Non-Coding RNAs.
LF373036 - JP 2014500723-A/180539: Polycomb-Associated Non-Coding RNAs.
MA608613 - JP 2018138019-A/180539: Polycomb-Associated Non-Coding RNAs.
LF373037 - JP 2014500723-A/180540: Polycomb-Associated Non-Coding RNAs.
MA608614 - JP 2018138019-A/180540: Polycomb-Associated Non-Coding RNAs.
LF373038 - JP 2014500723-A/180541: Polycomb-Associated Non-Coding RNAs.
MA608615 - JP 2018138019-A/180541: Polycomb-Associated Non-Coding RNAs.
LF373042 - JP 2014500723-A/180545: Polycomb-Associated Non-Coding RNAs.
MA608619 - JP 2018138019-A/180545: Polycomb-Associated Non-Coding RNAs.
LF373043 - JP 2014500723-A/180546: Polycomb-Associated Non-Coding RNAs.
MA608620 - JP 2018138019-A/180546: Polycomb-Associated Non-Coding RNAs.
LF373044 - JP 2014500723-A/180547: Polycomb-Associated Non-Coding RNAs.
MA608621 - JP 2018138019-A/180547: Polycomb-Associated Non-Coding RNAs.
LF373045 - JP 2014500723-A/180548: Polycomb-Associated Non-Coding RNAs.
MA608622 - JP 2018138019-A/180548: Polycomb-Associated Non-Coding RNAs.
LF373046 - JP 2014500723-A/180549: Polycomb-Associated Non-Coding RNAs.
MA608623 - JP 2018138019-A/180549: Polycomb-Associated Non-Coding RNAs.
LF373047 - JP 2014500723-A/180550: Polycomb-Associated Non-Coding RNAs.
MA608624 - JP 2018138019-A/180550: Polycomb-Associated Non-Coding RNAs.
LF373051 - JP 2014500723-A/180554: Polycomb-Associated Non-Coding RNAs.
MA608628 - JP 2018138019-A/180554: Polycomb-Associated Non-Coding RNAs.
LF373052 - JP 2014500723-A/180555: Polycomb-Associated Non-Coding RNAs.
MA608629 - JP 2018138019-A/180555: Polycomb-Associated Non-Coding RNAs.
LF373053 - JP 2014500723-A/180556: Polycomb-Associated Non-Coding RNAs.
MA608630 - JP 2018138019-A/180556: Polycomb-Associated Non-Coding RNAs.
LF373054 - JP 2014500723-A/180557: Polycomb-Associated Non-Coding RNAs.
MA608631 - JP 2018138019-A/180557: Polycomb-Associated Non-Coding RNAs.
JD531230 - Sequence 512254 from Patent EP1572962.
JD386682 - Sequence 367706 from Patent EP1572962.
JD041990 - Sequence 23014 from Patent EP1572962.
JD554619 - Sequence 535643 from Patent EP1572962.
JD167119 - Sequence 148143 from Patent EP1572962.
JD260897 - Sequence 241921 from Patent EP1572962.
JD227219 - Sequence 208243 from Patent EP1572962.
JD160094 - Sequence 141118 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03030 - DNA replication
hsa04110 - Cell cycle

BioCarta from NCI Cancer Genome Anatomy Project
h_mcmPathway - CDK Regulation of DNA Replication

-  Other Names for This Gene
  Alternate Gene Symbols: AB209612, ENST00000493076.1, ENST00000493076.2, ENST00000493076.3, ENST00000493076.4, uc003anw.1, uc003anw.2
UCSC ID: ENST00000493076.5
RefSeq Accession: NM_006739

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.