Human Gene APOBEC3D (ENST00000216099.13) from GENCODE V44
Description: Homo sapiens apolipoprotein B mRNA editing enzyme catalytic subunit 3D (APOBEC3D), transcript variant 1, mRNA. (from RefSeq NM_152426) RefSeq Summary (NM_152426): This gene is a member of the cytidine deaminase gene family. It is one of a group of related genes found in a cluster, thought to result from gene duplication, on chromosome 22. Members of the cluster encode proteins that are structurally and functionally related to the C to U RNA-editing cytidine deaminase APOBEC1 and inhibit retroviruses, such as HIV, by deaminating cytosine residues in nascent retroviral cDNA. [provided by RefSeq, Jul 2008]. Sequence Note: This RefSeq was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000216099.13 Gencode Gene: ENSG00000243811.12 Transcript (Including UTRs) Position: hg38 chr22:39,021,127-39,033,277 Size: 12,151 Total Exon Count: 7 Strand: + Coding Region Position: hg38 chr22:39,021,520-39,032,316 Size: 10,797 Coding Exon Count: 7
ID:ABC3D_HUMAN DESCRIPTION: RecName: Full=Probable DNA dC->dU-editing enzyme APOBEC-3D; EC=3.5.4.-; FUNCTION: Probable DNA cytidine deaminase involved in foreign DNA clearance. May provide cellular innate resistance to a specific panel of genetic invaders including endogenous retroelements and a subset of viruses. CATALYTIC ACTIVITY: Cytidine + H(2)O = uridine + NH(3). COFACTOR: Zinc (By similarity). TISSUE SPECIFICITY: Expressed in lymphoid organs. Also detected in non-lymphoid tissues including lung. MISCELLANEOUS: It is one of seven related genes or pseudogenes found in a cluster, thought to result from gene duplication, on chromosome 22. SIMILARITY: Belongs to the cytidine and deoxycytidylate deaminase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q96AK3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0003824 catalytic activity GO:0008270 zinc ion binding GO:0016787 hydrolase activity GO:0016814 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines GO:0046872 metal ion binding
Biological Process: GO:0002376 immune system process GO:0010529 negative regulation of transposition GO:0045087 innate immune response GO:0045869 negative regulation of single stranded viral RNA replication via double stranded DNA intermediate GO:0051607 defense response to virus GO:0070383 DNA cytosine deamination