Human Gene SEPTIN3 (ENST00000396426.7) from GENCODE V44
Description: Homo sapiens septin 3 (SEPTIN3), transcript variant A, mRNA. (from RefSeq NM_145733) RefSeq Summary (NM_145733): This gene belongs to the septin family of GTPases. Members of this family are required for cytokinesis. Expression is upregulated by retinoic acid in a human teratocarcinoma cell line. The specific function of this gene has not been determined. Alternative splicing of this gene results in several transcript variants encoding different isoforms. [provided by RefSeq, May 2018]. Gencode Transcript: ENST00000396426.7 Gencode Gene: ENSG00000100167.21 Transcript (Including UTRs) Position: hg38 chr22:41,976,810-41,998,221 Size: 21,412 Total Exon Count: 11 Strand: + Coding Region Position: hg38 chr22:41,977,065-41,996,967 Size: 19,903 Coding Exon Count: 11
ID:SEPT3_HUMAN DESCRIPTION: RecName: Full=Neuronal-specific septin-3; FUNCTION: Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). SUBUNIT: Septins polymerize into heterooligomeric protein complexes that form filaments, and can associate with cellular membranes, actin filaments and microtubules. GTPase activity is required for filament formation (By similarity). SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, synapse (By similarity). TISSUE SPECIFICITY: Brain-specific. INDUCTION: Up-regulated during neuronal differentiation. PTM: Phosphorylated by PKG on serine residues. Phosphorylated by PKG on Ser-91 (By similarity). SIMILARITY: Belongs to the septin family. SEQUENCE CAUTION: Sequence=AAG00517.1; Type=Erroneous initiation; Sequence=AAG00518.1; Type=Erroneous initiation; Sequence=AAG00519.1; Type=Erroneous initiation; Sequence=AAI11780.2; Type=Erroneous initiation; Sequence=CAD38797.1; Type=Erroneous initiation; Sequence=CAG30458.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9UH03
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.