Human Gene MCAT (ENST00000327555.5) from GENCODE V44
Description: Homo sapiens malonyl-CoA-acyl carrier protein transacylase (MCAT), transcript variant 3, non-coding RNA. (from RefSeq NR_046423) RefSeq Summary (NM_014507): The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Mar 2012]. Gencode Transcript: ENST00000327555.5 Gencode Gene: ENSG00000100294.13 Transcript (Including UTRs) Position: hg38 chr22:43,132,880-43,143,364 Size: 10,485 Total Exon Count: 3 Strand: - Coding Region Position: hg38 chr22:43,133,455-43,143,348 Size: 9,894 Coding Exon Count: 3
ID:FABD_HUMAN DESCRIPTION: RecName: Full=Malonyl-CoA-acyl carrier protein transacylase, mitochondrial; Short=MCT; EC=2.3.1.39; AltName: Full=Mitochondrial malonyl CoA:ACP acyltransferase; AltName: Full=Mitochondrial malonyltransferase; AltName: Full=[Acyl-carrier-protein] malonyltransferase; Flags: Precursor; FUNCTION: Catalyzes the transfer of a malonyl moiety from malonyl- CoA to the free thiol group of the phosphopantetheine arm of the mitochondrial ACP protein (NDUFAB1). This suggests the existence of the biosynthesis of fatty acids in mitochondrias. CATALYTIC ACTIVITY: Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein]. PATHWAY: Lipid metabolism; fatty acid biosynthesis. SUBCELLULAR LOCATION: Mitochondrion. SIMILARITY: Belongs to the type II malonyltransferase family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q8IVS2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
