Human Gene PARVB (ENST00000338758.12) from GENCODE V44
Description: Homo sapiens parvin beta (PARVB), transcript variant 2, mRNA. (from RefSeq NM_013327) RefSeq Summary (NM_013327): This gene encodes a member of the parvin family of actin-binding proteins, which play a role in cytoskeleton organization and cell adhesion. These proteins are associated with focal contacts and contain calponin homology domains that bind to actin filaments. This family member binds to alphaPIX and alpha-actinin, and it can inhibit the activity of integrin-linked kinase. This protein also functions in tumor suppression. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]. Gencode Transcript: ENST00000338758.12 Gencode Gene: ENSG00000188677.15 Transcript (Including UTRs) Position: hg38 chr22:44,024,302-44,172,939 Size: 148,638 Total Exon Count: 13 Strand: + Coding Region Position: hg38 chr22:44,024,340-44,168,678 Size: 144,339 Coding Exon Count: 13
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HBI1
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AF303887 - Homo sapiens CLINT mRNA, complete cds. LF385066 - JP 2014500723-A/192569: Polycomb-Associated Non-Coding RNAs. MA620643 - JP 2018138019-A/192569: Polycomb-Associated Non-Coding RNAs. BC017461 - Homo sapiens parvin, beta, mRNA (cDNA clone IMAGE:4859691). AK309987 - Homo sapiens cDNA, FLJ17029. AK313957 - Homo sapiens cDNA, FLJ94603, highly similar to Homo sapiens parvin, beta (PARVB), mRNA. BC046103 - Homo sapiens parvin, beta, mRNA (cDNA clone MGC:57521 IMAGE:5763848), complete cds. AB048276 - Homo sapiens mRNA for affixin, complete cds. AF151814 - Homo sapiens CGI-56 protein mRNA, complete cds. AF237769 - Homo sapiens beta-parvin (PARVB) mRNA, complete cds. AL159142 - Novel human gene mapping to chomosome 22. AK308443 - Homo sapiens cDNA, FLJ98391. BC039811 - Homo sapiens, Similar to parvin, beta, clone IMAGE:5757378, mRNA. LF337527 - JP 2014500723-A/145030: Polycomb-Associated Non-Coding RNAs. MA573104 - JP 2018138019-A/145030: Polycomb-Associated Non-Coding RNAs. JD061934 - Sequence 42958 from Patent EP1572962. JD181023 - Sequence 162047 from Patent EP1572962. JD275166 - Sequence 256190 from Patent EP1572962. JD045035 - Sequence 26059 from Patent EP1572962. JD126407 - Sequence 107431 from Patent EP1572962. JD121715 - Sequence 102739 from Patent EP1572962. JD054700 - Sequence 35724 from Patent EP1572962. JD263153 - Sequence 244177 from Patent EP1572962. JD442239 - Sequence 423263 from Patent EP1572962. JD287615 - Sequence 268639 from Patent EP1572962. JD458997 - Sequence 440021 from Patent EP1572962. JD391686 - Sequence 372710 from Patent EP1572962. JD395908 - Sequence 376932 from Patent EP1572962. JD535554 - Sequence 516578 from Patent EP1572962. LF337529 - JP 2014500723-A/145032: Polycomb-Associated Non-Coding RNAs. MA573106 - JP 2018138019-A/145032: Polycomb-Associated Non-Coding RNAs. LF337530 - JP 2014500723-A/145033: Polycomb-Associated Non-Coding RNAs. MA573107 - JP 2018138019-A/145033: Polycomb-Associated Non-Coding RNAs.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04510 - Focal adhesion
Reactome (by CSHL, EBI, and GO)
Protein Q9HBI1 (Reactome details) participates in the following event(s):
R-HSA-430308 PARVB interacts with Alpha-actinin R-HSA-432946 PARVB/Affixin interacts with alpha PIX R-HSA-446391 Formation of the PINCH-ILK-parvin complex R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components R-HSA-446353 Cell-extracellular matrix interactions R-HSA-446728 Cell junction organization R-HSA-1500931 Cell-Cell communication