Human Gene FAM118A (ENST00000441876.7) from GENCODE V44
  Description: Homo sapiens family with sequence similarity 118 member A (FAM118A), transcript variant 2, mRNA. (from RefSeq NM_017911)
Gencode Transcript: ENST00000441876.7
Gencode Gene: ENSG00000100376.12
Transcript (Including UTRs)
   Position: hg38 chr22:45,309,934-45,341,955 Size: 32,022 Total Exon Count: 9 Strand: +
Coding Region
   Position: hg38 chr22:45,322,380-45,340,405 Size: 18,026 Coding Exon Count: 8 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr22:45,309,934-45,341,955)mRNA (may differ from genome)Protein (357 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMGIneXtProtPubMed
UniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: F118A_HUMAN
DESCRIPTION: RecName: Full=Protein FAM118A;
SUBCELLULAR LOCATION: Membrane; Single-pass membrane protein (Potential).
SIMILARITY: Belongs to the FAM118 family.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 15.29 RPKM in Testis
Total median expression: 268.81 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -126.70259-0.489 Picture PostScript Text
3' UTR -483.001550-0.312 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  ModBase Predicted Comparative 3D Structure on Q9NWS6
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding
GO:0042802 identical protein binding

Cellular Component:
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  AK125027 - Homo sapiens cDNA FLJ43037 fis, clone BRTHA3002933, highly similar to Protein FAM118A.
AK000642 - Homo sapiens cDNA FLJ20635 fis, clone KAT03466.
JD462706 - Sequence 443730 from Patent EP1572962.
JD526180 - Sequence 507204 from Patent EP1572962.
BC013696 - Homo sapiens family with sequence similarity 118, member A, mRNA (cDNA clone MGC:8848 IMAGE:3860694), complete cds.
CR456403 - Homo sapiens bK268H5.4 full length open reading frame (ORF) cDNA clone (cDNA clone C22ORF:pGEM.bK268H5.4).
AB528129 - Synthetic construct DNA, clone: pF1KE0487, Homo sapiens FAM118A gene for family with sequence similarity 118, member A, without stop codon, in Flexi system.
CU013249 - Homo sapiens C22orf8, mRNA (cDNA clone IMAGE:100000028), complete cds, without stop codon, in Gateway system.
KJ899057 - Synthetic construct Homo sapiens clone ccsbBroadEn_08451 FAM118A gene, encodes complete protein.
CU012961 - Homo sapiens C22orf8, mRNA (cDNA clone IMAGE:100000124), complete cds, with stop codon, in Gateway system.
DQ593805 - Homo sapiens piRNA piR-33917, complete sequence.
DQ586951 - Homo sapiens piRNA piR-54063, complete sequence.
AK302205 - Homo sapiens cDNA FLJ61185 complete cds, highly similar to Protein FAM118A.
JD402800 - Sequence 383824 from Patent EP1572962.
JD404462 - Sequence 385486 from Patent EP1572962.
JD511246 - Sequence 492270 from Patent EP1572962.
JD355973 - Sequence 336997 from Patent EP1572962.
JD204313 - Sequence 185337 from Patent EP1572962.
JD427323 - Sequence 408347 from Patent EP1572962.
AK026239 - Homo sapiens cDNA: FLJ22586 fis, clone HSI02774.

-  Other Names for This Gene
  Alternate Gene Symbols: B3KWG4, C22orf8, ENST00000441876.1, ENST00000441876.2, ENST00000441876.3, ENST00000441876.4, ENST00000441876.5, ENST00000441876.6, F118A_HUMAN, NM_017911, Q5TII5, Q96CY3, Q9NWS6, uc003bga.1, uc003bga.2, uc003bga.3, uc003bga.4, uc003bga.5, uc003bga.6
UCSC ID: ENST00000441876.7
RefSeq Accession: NM_017911
Protein: Q9NWS6 (aka F118A_HUMAN)
CCDS: CCDS14065.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.