Human Gene GNAI2 (ENST00000422163.5) from GENCODE V44
Description: Homo sapiens G protein subunit alpha i2 (GNAI2), transcript variant 6, mRNA. (from RefSeq NM_001282620) RefSeq Summary (NM_001282620): The protein encoded by this gene is an alpha subunit of guanine nucleotide binding proteins (G proteins). The encoded protein contains the guanine nucleotide binding site and is involved in the hormonal regulation of adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]. Gencode Transcript: ENST00000422163.5 Gencode Gene: ENSG00000114353.17 Transcript (Including UTRs) Position: hg38 chr3:50,226,292-50,258,898 Size: 32,607 Total Exon Count: 9 Strand: + Coding Region Position: hg38 chr3:50,227,124-50,257,690 Size: 30,567 Coding Exon Count: 8
ID:GNAI2_HUMAN DESCRIPTION: RecName: Full=Guanine nucleotide-binding protein G(i) subunit alpha-2; AltName: Full=Adenylate cyclase-inhibiting G alpha protein; FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. The G(i) proteins are involved in hormonal regulation of adenylate cyclase: they inhibit the cyclase in response to beta-adrenergic stimuli. May play a role in cell division. FUNCTION: Isoform sGi2: Regulates the cell surface density of dopamine receptors DRD2 by sequestrating them as an intracellular pool. SUBUNIT: G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. Interacts with GPSM1. Interacts with RGS12 and RGS14 (By similarity). Interacts with UNC5B. INTERACTION: Q99750:MDFI; NbExp=2; IntAct=EBI-353997, EBI-724076; SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton, centrosome. Cell membrane. Note=Localizes in the centrosomes of interphase and mitotic cells. Detected at the cleavage furrow and/or the midbody. SIMILARITY: Belongs to the G-alpha family. G(i/o/t/z) subfamily.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04899
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Protein P04899 (Reactome details) participates in the following event(s):
R-HSA-8850560 G-protein alpha releases G-protein heterotrimer from PDCL R-HSA-392206 G alpha (i) inhibits adenylate cyclase R-HSA-392212 G alpha (i) auto-inactivates by hydrolysing GTP to GDP R-HSA-392202 Dissociation of the P2Y purinoceptor 12:Gi complex R-HSA-749454 The Ligand:GPCR:Gi complex dissociates R-HSA-751001 Inactive G alpha (i) reassociates with G beta:gamma R-HSA-170674 Dissociation of the Gi alpha:G olf complex R-HSA-167433 G-protein beta-gamma subunits rebind the alpha-GDP subunit R-HSA-112037 Inactivation of PLC beta R-HSA-167415 G-protein alpha subunit is inactivated R-HSA-111870 Activation of PLC beta-1/4 R-HSA-112271 The receptor:G-protein complex dissociates R-HSA-167429 The receptor:G-protein complex binds GTP R-HSA-400037 Gi,Go Heterotrimeric G-protein complex dissociates R-HSA-170671 G alpha-olf:GTP binds to Gi alpha1:GTP:adenylate cyclase complex R-HSA-170686 Adenylate cyclase increases the GTPase activity of Gi alpha R-HSA-392187 Activated P2Y purinoceptor 12 binds G-protein Gi R-HSA-749456 Liganded Gi-activating GPCRs bind inactive heterotrimeric G-protein Gi R-HSA-167408 The high affinity receptor complex binds to G-protein R-HSA-167419 The receptor:G-protein complex releases GDP R-HSA-400092 Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins R-HSA-392195 Gi activation by P2Y purinoceptor 12 R-HSA-380073 Liganded Gi-activating GPCR acts as a GEF for Gi R-HSA-170666 Adenylate cyclase increases the GTPase activity of G alpha-olf R-HSA-111879 PIP2 hydrolysis R-HSA-6814122 Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding R-HSA-170670 Adenylate cyclase inhibitory pathway R-HSA-418594 G alpha (i) signalling events R-HSA-392170 ADP signalling through P2Y purinoceptor 12 R-HSA-202040 G-protein activation R-HSA-112043 PLC beta mediated events R-HSA-390466 Chaperonin-mediated protein folding R-HSA-400042 Adrenaline,noradrenaline inhibits insulin secretion R-HSA-112040 G-protein mediated events R-HSA-997269 Inhibition of adenylate cyclase pathway R-HSA-388396 GPCR downstream signalling R-HSA-392518 Signal amplification R-HSA-111885 Opioid Signalling R-HSA-391251 Protein folding R-HSA-422356 Regulation of insulin secretion R-HSA-991365 Activation of GABAB receptors R-HSA-372790 Signaling by GPCR R-HSA-76002 Platelet activation, signaling and aggregation R-HSA-392499 Metabolism of proteins R-HSA-163685 Energy Metabolism R-HSA-977444 GABA B receptor activation R-HSA-162582 Signal Transduction R-HSA-109582 Hemostasis R-HSA-1430728 Metabolism R-HSA-977443 GABA receptor activation R-HSA-112314 Neurotransmitter receptors and postsynaptic signal transmission R-HSA-112315 Transmission across Chemical Synapses R-HSA-112316 Neuronal System
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