Human Gene ARHGEF3 (ENST00000296315.8) from GENCODE V44
Description: Homo sapiens Rho guanine nucleotide exchange factor 3 (ARHGEF3), transcript variant 3, mRNA. (from RefSeq NM_019555) RefSeq Summary (NM_019555): Rho-like GTPases are involved in a variety of cellular processes, and they are activated by binding GTP and inactivated by conversion of GTP to GDP by their intrinsic GTPase activity. Guanine nucleotide exchange factors (GEFs) accelerate the GTPase activity of Rho GTPases by catalyzing their release of bound GDP. This gene encodes a guanine nucleotide exchange factor, which specifically activates two members of the Rho GTPase family: RHOA and RHOB, both of which have a role in bone cell biology. It has been identified that genetic variation in this gene plays a role in the determination of bone mineral density (BMD), indicating the implication of this gene in postmenopausal osteoporosis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000296315.8 Gencode Gene: ENSG00000163947.12 Transcript (Including UTRs) Position: hg38 chr3:56,727,420-56,801,949 Size: 74,530 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr3:56,729,270-56,801,798 Size: 72,529 Coding Exon Count: 10
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NR81
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0007186 G-protein coupled receptor signaling pathway GO:0007266 Rho protein signal transduction GO:0035023 regulation of Rho protein signal transduction GO:0035556 intracellular signal transduction GO:0043065 positive regulation of apoptotic process GO:0051056 regulation of small GTPase mediated signal transduction
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Sequence and Links to Tools and Databases 
Microarray Expression Data 
