Human Gene FRMD4B (ENST00000478263.5) from GENCODE V44
  Description: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data. (from UniProt E9PGA7)
RefSeq Summary (NM_015123): This gene encodes a GRP1-binding protein which contains a FERM protein interaction domain as well as two coiled coil domains. This protein may play a role as a scaffolding protein. [provided by RefSeq, Mar 2014]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data because no single transcript was available for the full length of the gene. The extent of this transcript is supported by transcript alignments.
Gencode Transcript: ENST00000478263.5
Gencode Gene: ENSG00000114541.15
Transcript (Including UTRs)
   Position: hg38 chr3:69,170,807-69,200,848 Size: 30,042 Total Exon Count: 13 Strand: -
Coding Region
   Position: hg38 chr3:69,171,861-69,196,947 Size: 25,087 Coding Exon Count: 11 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:69,170,807-69,200,848)mRNA (may differ from genome)Protein (686 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Comments and Description Text from UniProtKB
  ID: E9PGA7_HUMAN
DESCRIPTION: SubName: Full=FERM domain-containing protein 4B;
CAUTION: The sequence shown here is derived from an Ensembl automatic analysis pipeline and should be considered as preliminary data.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 11.84 RPKM in Thyroid
Total median expression: 178.13 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -190.50646-0.295 Picture PostScript Text
3' UTR -260.701054-0.247 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR021774 - DUF3338

Pfam Domains:
PF11819 - Domain of unknown function (DUF3338)

ModBase Predicted Comparative 3D Structure on E9PGA7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Descriptions from all associated GenBank mRNAs
  AB023230 - Homo sapiens KIAA1013 mRNA for KIAA1013 protein.
AK091076 - Homo sapiens cDNA FLJ33757 fis, clone BRCAN2000563.
AK295045 - Homo sapiens cDNA FLJ57979 complete cds, highly similar to FERM domain-containing protein 4B.
BC172315 - Synthetic construct Homo sapiens clone IMAGE:100069009, MGC:199020 FERM domain containing 4B (FRMD4B) mRNA, encodes complete protein.
AK000244 - Homo sapiens cDNA FLJ20237 fis, clone COLF5879, highly similar to AB023230 Homo sapiens mRNA for KIAA1013 protein.
BC110637 - Homo sapiens FERM domain containing 4B, mRNA (cDNA clone IMAGE:4479062), partial cds.
AL110231 - Homo sapiens mRNA; cDNA DKFZp564B0371 (from clone DKFZp564B0371).
AK024086 - Homo sapiens cDNA FLJ14024 fis, clone HEMBA1003646, highly similar to FERM domain-containing protein 4B.
BC028291 - Homo sapiens FERM domain containing 4B, mRNA (cDNA clone IMAGE:4508579), partial cds.
AL832231 - Homo sapiens mRNA; cDNA DKFZp686E1053 (from clone DKFZp686E1053).
BC043396 - Homo sapiens cDNA clone IMAGE:5585350, containing frame-shift errors.
JD092391 - Sequence 73415 from Patent EP1572962.
JD486485 - Sequence 467509 from Patent EP1572962.
JD429771 - Sequence 410795 from Patent EP1572962.
JD318698 - Sequence 299722 from Patent EP1572962.
JD038161 - Sequence 19185 from Patent EP1572962.
JD341254 - Sequence 322278 from Patent EP1572962.
JD373501 - Sequence 354525 from Patent EP1572962.
JD452862 - Sequence 433886 from Patent EP1572962.
JD318408 - Sequence 299432 from Patent EP1572962.
JD157117 - Sequence 138141 from Patent EP1572962.
JD208064 - Sequence 189088 from Patent EP1572962.
JD038511 - Sequence 19535 from Patent EP1572962.
JD050288 - Sequence 31312 from Patent EP1572962.
JD530773 - Sequence 511797 from Patent EP1572962.
JD192760 - Sequence 173784 from Patent EP1572962.
JD438521 - Sequence 419545 from Patent EP1572962.
JD101302 - Sequence 82326 from Patent EP1572962.
JD024719 - Sequence 5743 from Patent EP1572962.
JD035687 - Sequence 16711 from Patent EP1572962.
JD420236 - Sequence 401260 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: AL832231, E9PGA7, E9PGA7_HUMAN, ENST00000478263.1, ENST00000478263.2, ENST00000478263.3, ENST00000478263.4, uc003dnu.1, uc003dnu.2, uc003dnu.3
UCSC ID: ENST00000478263.5
RefSeq Accession: NM_015123
Protein: E9PGA7

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.