Human Gene UPK1B (ENST00000264234.8) from GENCODE V44
Description: Homo sapiens uroplakin 1B (UPK1B), mRNA. (from RefSeq NM_006952) RefSeq Summary (NM_006952): The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is found in the asymmetrical unit membrane (AUM) where it can form a complex with other transmembrane 4 superfamily proteins. It may play a role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000264234.8 Gencode Gene: ENSG00000114638.8 Transcript (Including UTRs) Position: hg38 chr3:119,173,598-119,205,143 Size: 31,546 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr3:119,186,742-119,203,967 Size: 17,226 Coding Exon Count: 7
ID:UPK1B_HUMAN DESCRIPTION: RecName: Full=Uroplakin-1b; Short=UP1b; AltName: Full=Tetraspanin-20; Short=Tspan-20; AltName: Full=Uroplakin Ib; Short=UPIb; FUNCTION: Component of the asymmetric unit membrane (AUM); a highly specialized biomembrane elaborated by terminally differentiated urothelial cells. May play an important role in normal bladder epithelial physiology, possibly in regulating membrane permeability of superficial umbrella cells or in stabilizing the apical membrane through AUM/cytoskeletal interactions (By similarity). SUBUNIT: Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B) (By similarity). SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Bladder epithelium. PTM: N-glycosylated with high-mannose oligosaccharides (By similarity). SIMILARITY: Belongs to the tetraspanin (TM4SF) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O75841
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
