Human Gene SLCO2A1 (ENST00000310926.11) from GENCODE V44
  Description: Homo sapiens solute carrier organic anion transporter family member 2A1 (SLCO2A1), mRNA. (from RefSeq NM_005630)
RefSeq Summary (NM_005630): This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments.
Gencode Transcript: ENST00000310926.11
Gencode Gene: ENSG00000174640.15
Transcript (Including UTRs)
   Position: hg38 chr3:133,932,701-134,029,925 Size: 97,225 Total Exon Count: 14 Strand: -
Coding Region
   Position: hg38 chr3:133,934,713-134,029,802 Size: 95,090 Coding Exon Count: 14 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:133,932,701-134,029,925)mRNA (may differ from genome)Protein (643 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBWikipediaBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SO2A1_HUMAN
DESCRIPTION: RecName: Full=Solute carrier organic anion transporter family member 2A1; AltName: Full=Prostaglandin transporter; Short=PGT; AltName: Full=Solute carrier family 21 member 2;
FUNCTION: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A.
INTERACTION: P62993:GRB2; NbExp=1; IntAct=EBI-1760532, EBI-401755;
SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein.
TISSUE SPECIFICITY: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart.
DISEASE: Defects in SLCO2A1 are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 2 (PHOAR2) [MIM:614441]. PHOAR2 is a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease.
SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family.
SIMILARITY: Contains 1 Kazal-like domain.
WEB RESOURCE: Name=Solute carrier organic anion transporter family, member 2A1 (SLCO2A1); Note=Leiden Open Variation Database (LOVD); URL="http://www.lovd.nl/SLCO2A1";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: SLCO2A1
Diseases sorted by gene-association score: hypertrophic osteoarthropathy, primary, autosomal recessive 2* (1331), chronic enteropathy associated with slco2a1 gene* (350), primary hypertrophic osteoarthropathy (20), secondary hypertrophic osteoarthropathy (19), neurogenic arthropathy (16), gastritis, familial giant hypertrophic (9), hydrarthrosis (9), periostitis (8), seborrheic dermatitis (7), caffey disease (6), hypervitaminosis a (5)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 97.29 RPKM in Lung
Total median expression: 695.53 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -38.00123-0.309 Picture PostScript Text
3' UTR -693.202012-0.345 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011497 - Kazal-type_dom
IPR020846 - MFS_dom
IPR016196 - MFS_dom_general_subst_transpt
IPR004156 - OA_transporter
IPR002350 - Prot_inh_Kazal

Pfam Domains:
PF07648 - Kazal-type serine protease inhibitor domain
PF03137 - Organic Anion Transporter Polypeptide (OATP) family

Protein Data Bank (PDB) 3-D Structure
MuPIT help
3MRR - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on Q92959
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserNo orthologGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
MGIRGDEnsembl WormBase 
Protein SequenceProtein SequenceProtein Sequence Protein Sequence 
AlignmentAlignmentAlignment Alignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0005319 lipid transporter activity
GO:0015132 prostaglandin transmembrane transporter activity
GO:0015347 sodium-independent organic anion transmembrane transporter activity

Biological Process:
GO:0006869 lipid transport
GO:0015732 prostaglandin transport
GO:0043252 sodium-independent organic anion transport
GO:0055085 transmembrane transport

Cellular Component:
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane


-  Descriptions from all associated GenBank mRNAs
  U70867 - Homo sapiens prostaglandin transporter hPGT mRNA, complete cds.
BC041140 - Homo sapiens solute carrier organic anion transporter family, member 2A1, mRNA (cDNA clone MGC:47708 IMAGE:5751516), complete cds.
BC051347 - Homo sapiens solute carrier organic anion transporter family, member 2A1, mRNA (cDNA clone MGC:59812 IMAGE:6481104), complete cds.
KJ892158 - Synthetic construct Homo sapiens clone ccsbBroadEn_01552 SLCO2A1 gene, encodes complete protein.
AK303550 - Homo sapiens cDNA FLJ50336 complete cds, highly similar to Solute carrier organic anion transporter family member 2A1.
AK309561 - Homo sapiens cDNA, FLJ99602.
JD323425 - Sequence 304449 from Patent EP1572962.
JD115344 - Sequence 96368 from Patent EP1572962.
JD554679 - Sequence 535703 from Patent EP1572962.
JD189513 - Sequence 170537 from Patent EP1572962.
JD441896 - Sequence 422920 from Patent EP1572962.
JD350216 - Sequence 331240 from Patent EP1572962.
JD539138 - Sequence 520162 from Patent EP1572962.
JD133145 - Sequence 114169 from Patent EP1572962.
JD415870 - Sequence 396894 from Patent EP1572962.
JD527768 - Sequence 508792 from Patent EP1572962.
JD153394 - Sequence 134418 from Patent EP1572962.
JD403973 - Sequence 384997 from Patent EP1572962.
JD340053 - Sequence 321077 from Patent EP1572962.
JD498356 - Sequence 479380 from Patent EP1572962.
JD373815 - Sequence 354839 from Patent EP1572962.
JD477712 - Sequence 458736 from Patent EP1572962.
JD217266 - Sequence 198290 from Patent EP1572962.
JD429211 - Sequence 410235 from Patent EP1572962.
JD371705 - Sequence 352729 from Patent EP1572962.
JD514577 - Sequence 495601 from Patent EP1572962.
JD251623 - Sequence 232647 from Patent EP1572962.
JD266261 - Sequence 247285 from Patent EP1572962.
JD524643 - Sequence 505667 from Patent EP1572962.
JD122952 - Sequence 103976 from Patent EP1572962.
JD120009 - Sequence 101033 from Patent EP1572962.
JD110217 - Sequence 91241 from Patent EP1572962.
JD147985 - Sequence 129009 from Patent EP1572962.
JD516668 - Sequence 497692 from Patent EP1572962.
JD546984 - Sequence 528008 from Patent EP1572962.
JD062254 - Sequence 43278 from Patent EP1572962.
JD396434 - Sequence 377458 from Patent EP1572962.
JD162748 - Sequence 143772 from Patent EP1572962.
JD352754 - Sequence 333778 from Patent EP1572962.
JD227176 - Sequence 208200 from Patent EP1572962.
JD308554 - Sequence 289578 from Patent EP1572962.
JD291183 - Sequence 272207 from Patent EP1572962.
JD322559 - Sequence 303583 from Patent EP1572962.
JD112967 - Sequence 93991 from Patent EP1572962.
JD274169 - Sequence 255193 from Patent EP1572962.
JD508222 - Sequence 489246 from Patent EP1572962.
JD488618 - Sequence 469642 from Patent EP1572962.
JD045726 - Sequence 26750 from Patent EP1572962.
JD520885 - Sequence 501909 from Patent EP1572962.
JD187058 - Sequence 168082 from Patent EP1572962.
JD387147 - Sequence 368171 from Patent EP1572962.
JD537585 - Sequence 518609 from Patent EP1572962.
JD565144 - Sequence 546168 from Patent EP1572962.
JD375257 - Sequence 356281 from Patent EP1572962.
JD122283 - Sequence 103307 from Patent EP1572962.
JD503399 - Sequence 484423 from Patent EP1572962.
JD516862 - Sequence 497886 from Patent EP1572962.
JD402054 - Sequence 383078 from Patent EP1572962.
JD123332 - Sequence 104356 from Patent EP1572962.
JD190590 - Sequence 171614 from Patent EP1572962.
JD376961 - Sequence 357985 from Patent EP1572962.
JD107260 - Sequence 88284 from Patent EP1572962.
JD142083 - Sequence 123107 from Patent EP1572962.
JD137717 - Sequence 118741 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q92959 (Reactome details) participates in the following event(s):

R-HSA-879528 SLCO2A1 transports PGT substrates from extracellular region to cytosol
R-HSA-879518 Transport of organic anions
R-HSA-425397 Transport of vitamins, nucleosides, and related molecules
R-HSA-425407 SLC-mediated transmembrane transport
R-HSA-382551 Transport of small molecules

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000310926.1, ENST00000310926.10, ENST00000310926.2, ENST00000310926.3, ENST00000310926.4, ENST00000310926.5, ENST00000310926.6, ENST00000310926.7, ENST00000310926.8, ENST00000310926.9, NM_005630, OATP2A1, Q86V98, Q8IUN2, Q92959, SLC21A2, SO2A1_HUMAN, uc003eqa.1, uc003eqa.2, uc003eqa.3, uc003eqa.4, uc003eqa.5, uc003eqa.6, uc003eqa.7
UCSC ID: ENST00000310926.11
RefSeq Accession: NM_005630
Protein: Q92959 (aka SO2A1_HUMAN or S2A1_HUMAN)
CCDS: CCDS3084.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.