Human Gene SLCO2A1 (ENST00000310926.11) from GENCODE V44
Description: Homo sapiens solute carrier organic anion transporter family member 2A1 (SLCO2A1), mRNA. (from RefSeq NM_005630) RefSeq Summary (NM_005630): This gene encodes a prostaglandin transporter that is a member of the 12-membrane-spanning superfamily of transporters. The encoded protein may be involved in mediating the uptake and clearance of prostaglandins in numerous tissues. [provided by RefSeq, Dec 2011]. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on alignments. Gencode Transcript: ENST00000310926.11 Gencode Gene: ENSG00000174640.15 Transcript (Including UTRs) Position: hg38 chr3:133,932,701-134,029,925 Size: 97,225 Total Exon Count: 14 Strand: - Coding Region Position: hg38 chr3:133,934,713-134,029,802 Size: 95,090 Coding Exon Count: 14
ID:SO2A1_HUMAN DESCRIPTION: RecName: Full=Solute carrier organic anion transporter family member 2A1; AltName: Full=Prostaglandin transporter; Short=PGT; AltName: Full=Solute carrier family 21 member 2; FUNCTION: May mediate the release of newly synthesized prostaglandins from cells, the transepithelial transport of prostaglandins, and the clearance of prostaglandins from the circulation. Transports PGD2, as well as PGE1, PGE2 and PGF2A. INTERACTION: P62993:GRB2; NbExp=1; IntAct=EBI-1760532, EBI-401755; SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Ubiquitous. Significant expression observed in ling, kidney, spleen, and heart. DISEASE: Defects in SLCO2A1 are the cause of hypertrophic osteoarthropathy, primary, autosomal recessive, type 2 (PHOAR2) [MIM:614441]. PHOAR2 is a disease characterized by digital clubbing, periostosis, acroosteolysis, painful joint enlargement, and variable features of pachydermia that include thickened facial skin and a thickened scalp. Other developmental anomalies include delayed closure of the cranial sutures and congenital heart disease. SIMILARITY: Belongs to the organo anion transporter (TC 2.A.60) family. SIMILARITY: Contains 1 Kazal-like domain. WEB RESOURCE: Name=Solute carrier organic anion transporter family, member 2A1 (SLCO2A1); Note=Leiden Open Variation Database (LOVD); URL="http://www.lovd.nl/SLCO2A1";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q92959
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006869 lipid transport GO:0015732 prostaglandin transport GO:0043252 sodium-independent organic anion transport GO:0055085 transmembrane transport
U70867 - Homo sapiens prostaglandin transporter hPGT mRNA, complete cds. BC041140 - Homo sapiens solute carrier organic anion transporter family, member 2A1, mRNA (cDNA clone MGC:47708 IMAGE:5751516), complete cds. BC051347 - Homo sapiens solute carrier organic anion transporter family, member 2A1, mRNA (cDNA clone MGC:59812 IMAGE:6481104), complete cds. KJ892158 - Synthetic construct Homo sapiens clone ccsbBroadEn_01552 SLCO2A1 gene, encodes complete protein. AK303550 - Homo sapiens cDNA FLJ50336 complete cds, highly similar to Solute carrier organic anion transporter family member 2A1. AK309561 - Homo sapiens cDNA, FLJ99602. JD323425 - Sequence 304449 from Patent EP1572962. JD115344 - Sequence 96368 from Patent EP1572962. JD554679 - Sequence 535703 from Patent EP1572962. JD189513 - Sequence 170537 from Patent EP1572962. JD441896 - Sequence 422920 from Patent EP1572962. JD350216 - Sequence 331240 from Patent EP1572962. JD539138 - Sequence 520162 from Patent EP1572962. JD133145 - Sequence 114169 from Patent EP1572962. JD415870 - Sequence 396894 from Patent EP1572962. JD527768 - Sequence 508792 from Patent EP1572962. JD153394 - Sequence 134418 from Patent EP1572962. JD403973 - Sequence 384997 from Patent EP1572962. JD340053 - Sequence 321077 from Patent EP1572962. JD498356 - Sequence 479380 from Patent EP1572962. JD373815 - Sequence 354839 from Patent EP1572962. JD477712 - Sequence 458736 from Patent EP1572962. JD217266 - Sequence 198290 from Patent EP1572962. JD429211 - Sequence 410235 from Patent EP1572962. JD371705 - Sequence 352729 from Patent EP1572962. JD514577 - Sequence 495601 from Patent EP1572962. JD251623 - Sequence 232647 from Patent EP1572962. JD266261 - Sequence 247285 from Patent EP1572962. JD524643 - Sequence 505667 from Patent EP1572962. JD122952 - Sequence 103976 from Patent EP1572962. JD120009 - Sequence 101033 from Patent EP1572962. JD110217 - Sequence 91241 from Patent EP1572962. JD147985 - Sequence 129009 from Patent EP1572962. JD516668 - Sequence 497692 from Patent EP1572962. JD546984 - Sequence 528008 from Patent EP1572962. JD062254 - Sequence 43278 from Patent EP1572962. JD396434 - Sequence 377458 from Patent EP1572962. JD162748 - Sequence 143772 from Patent EP1572962. JD352754 - Sequence 333778 from Patent EP1572962. JD227176 - Sequence 208200 from Patent EP1572962. JD308554 - Sequence 289578 from Patent EP1572962. JD291183 - Sequence 272207 from Patent EP1572962. JD322559 - Sequence 303583 from Patent EP1572962. JD112967 - Sequence 93991 from Patent EP1572962. JD274169 - Sequence 255193 from Patent EP1572962. JD508222 - Sequence 489246 from Patent EP1572962. JD488618 - Sequence 469642 from Patent EP1572962. JD045726 - Sequence 26750 from Patent EP1572962. JD520885 - Sequence 501909 from Patent EP1572962. JD187058 - Sequence 168082 from Patent EP1572962. JD387147 - Sequence 368171 from Patent EP1572962. JD537585 - Sequence 518609 from Patent EP1572962. JD565144 - Sequence 546168 from Patent EP1572962. JD375257 - Sequence 356281 from Patent EP1572962. JD122283 - Sequence 103307 from Patent EP1572962. JD503399 - Sequence 484423 from Patent EP1572962. JD516862 - Sequence 497886 from Patent EP1572962. JD402054 - Sequence 383078 from Patent EP1572962. JD123332 - Sequence 104356 from Patent EP1572962. JD190590 - Sequence 171614 from Patent EP1572962. JD376961 - Sequence 357985 from Patent EP1572962. JD107260 - Sequence 88284 from Patent EP1572962. JD142083 - Sequence 123107 from Patent EP1572962. JD137717 - Sequence 118741 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q92959 (Reactome details) participates in the following event(s):
R-HSA-879528 SLCO2A1 transports PGT substrates from extracellular region to cytosol R-HSA-879518 Transport of organic anions R-HSA-425397 Transport of vitamins, nucleosides, and related molecules R-HSA-425407 SLC-mediated transmembrane transport R-HSA-382551 Transport of small molecules