Human Gene ARMC8 (ENST00000471453.5) from GENCODE V44
  Description: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8IUR7-1; Sequence=Displayed; Name=2; IsoId=Q8IUR7-2; Sequence=VSP_024509; Note=No experimental confirmation available; Name=3; IsoId=Q8IUR7-3; Sequence=VSP_024512; Note=No experimental confirmation available; Name=6; IsoId=Q8IUR7-6; Sequence=VSP_024509, VSP_024513, VSP_024514; (from UniProt Q8IUR7)
Gencode Transcript: ENST00000471453.5
Gencode Gene: ENSG00000114098.18
Transcript (Including UTRs)
   Position: hg38 chr3:138,187,529-138,246,857 Size: 59,329 Total Exon Count: 13 Strand: +
Coding Region
   Position: hg38 chr3:138,188,528-138,245,249 Size: 56,722 Coding Exon Count: 12 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
Microarray ExpressionRNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA Descriptions
PathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr3:138,187,529-138,246,857)mRNA (may differ from genome)Protein (385 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
HPRDLynxMalacardsMGIneXtProtPubMed
ReactomeUniProtKB

-  Comments and Description Text from UniProtKB
  ID: ARMC8_HUMAN
DESCRIPTION: RecName: Full=Armadillo repeat-containing protein 8;
SIMILARITY: Contains 14 ARM repeats.
SEQUENCE CAUTION: Sequence=BAA91861.1; Type=Frameshift; Positions=468; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention;

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 22.16 RPKM in Brain - Cerebellar Hemisphere
Total median expression: 344.33 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -44.20144-0.307 Picture PostScript Text
3' UTR -375.701608-0.234 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo

Pfam Domains:
PF00514 - Armadillo/beta-catenin-like repeat

ModBase Predicted Comparative 3D Structure on Q8IUR7
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005515 protein binding

Biological Process:
GO:0043312 neutrophil degranulation

Cellular Component:
GO:0005576 extracellular region
GO:0035580 specific granule lumen
GO:1904724 tertiary granule lumen


-  Descriptions from all associated GenBank mRNAs
  BC032661 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:45133 IMAGE:5530425), complete cds.
AK296757 - Homo sapiens cDNA FLJ56387 complete cds, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA.
AK299769 - Homo sapiens cDNA FLJ53383 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.
AK304558 - Homo sapiens cDNA FLJ54248 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.
AK296837 - Homo sapiens cDNA FLJ55707 complete cds, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA.
BC041699 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:48800 IMAGE:5240423), complete cds.
AK001721 - Homo sapiens cDNA FLJ10859 fis, clone NT2RP4001567, weakly similar to ARMADILLO SEGMENT POLARITY PROTEIN.
AK315932 - Homo sapiens cDNA, FLJ78831 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.
AK299229 - Homo sapiens cDNA FLJ56232 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.
AK001882 - Homo sapiens cDNA FLJ11020 fis, clone PLACE1003625, weakly similar to ARMADILLO SEGMENT POLARITY PROTEIN.
AF161541 - Homo sapiens HSPC056 mRNA, complete cds.
BC013424 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:10058 IMAGE:3892143), complete cds.
AF109184 - Homo sapiens S863-2 mRNA, complete cds.
AK289577 - Homo sapiens cDNA FLJ76733 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 1, mRNA.
JD449842 - Sequence 430866 from Patent EP1572962.
BC007934 - Homo sapiens cDNA clone IMAGE:4127359, **** WARNING: chimeric clone ****.
CU680606 - Synthetic construct Homo sapiens gateway clone IMAGE:100017148 5' read ARMC8 mRNA.
HQ448218 - Synthetic construct Homo sapiens clone IMAGE:100071619; CCSB003107_01 armadillo repeat containing 8 (ARMC8) gene, encodes complete protein.
KJ893478 - Synthetic construct Homo sapiens clone ccsbBroadEn_02872 ARMC8 gene, encodes complete protein.
AK098500 - Homo sapiens cDNA FLJ25634 fis, clone STM04154.
JD536010 - Sequence 517034 from Patent EP1572962.
JD356829 - Sequence 337853 from Patent EP1572962.
JD240620 - Sequence 221644 from Patent EP1572962.
JD176635 - Sequence 157659 from Patent EP1572962.
JD530114 - Sequence 511138 from Patent EP1572962.
JD394561 - Sequence 375585 from Patent EP1572962.
JD141266 - Sequence 122290 from Patent EP1572962.
JD096056 - Sequence 77080 from Patent EP1572962.
JD385794 - Sequence 366818 from Patent EP1572962.
JD176623 - Sequence 157647 from Patent EP1572962.
JD260786 - Sequence 241810 from Patent EP1572962.
JD113154 - Sequence 94178 from Patent EP1572962.
JD339729 - Sequence 320753 from Patent EP1572962.
JD136038 - Sequence 117062 from Patent EP1572962.
JD240497 - Sequence 221521 from Patent EP1572962.
JD386175 - Sequence 367199 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein Q8IUR7 (Reactome details) participates in the following event(s):

R-HSA-6798749 Exocytosis of specific granule lumen proteins
R-HSA-6798745 Exocytosis of tertiary granule lumen proteins
R-HSA-6798695 Neutrophil degranulation
R-HSA-168249 Innate Immune System
R-HSA-168256 Immune System

-  Other Names for This Gene
  Alternate Gene Symbols: A8K0L2, ARMC8_HUMAN, BC013424, D3DNE6, ENST00000471453.1, ENST00000471453.2, ENST00000471453.3, ENST00000471453.4, Q6PIL2, Q8IUR7, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9, S863-2, uc003erw.1, uc003erw.2, uc003erw.3, uc003erw.4, uc003erw.5, uc003erw.6
UCSC ID: ENST00000471453.5
RefSeq Accession: NM_014154
Protein: Q8IUR7 (aka ARMC8_HUMAN)
CCDS: CCDS3098.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.