Human Gene ARMC8 (ENST00000471453.5) from GENCODE V44
Description: Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8IUR7-1; Sequence=Displayed; Name=2; IsoId=Q8IUR7-2; Sequence=VSP_024509; Note=No experimental confirmation available; Name=3; IsoId=Q8IUR7-3; Sequence=VSP_024512; Note=No experimental confirmation available; Name=6; IsoId=Q8IUR7-6; Sequence=VSP_024509, VSP_024513, VSP_024514; (from UniProt Q8IUR7)
Gencode Transcript: ENST00000471453.5
Gencode Gene: ENSG00000114098.18
Transcript (Including UTRs)
Position: hg38 chr3:138,187,529-138,246,857 Size: 59,329 Total Exon Count: 13 Strand: +
Coding Region
Position: hg38 chr3:138,188,528-138,245,249 Size: 56,722 Coding Exon Count: 12
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: ARMC8_HUMAN
DESCRIPTION: RecName: Full=Armadillo repeat-containing protein 8;
SIMILARITY: Contains 14 ARM repeats.SEQUENCE CAUTION: Sequence=BAA91861.1; Type=Frameshift; Positions=468; Sequence=BAA91959.1; Type=Miscellaneous discrepancy; Note=Intron retention; Sequence=CAB46423.1; Type=Miscellaneous discrepancy; Note=Intron retention;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011989 - ARM-like
IPR016024 - ARM-type_fold
IPR000225 - Armadillo
Pfam Domains: PF00514 - Armadillo/beta-catenin-like repeat
ModBase Predicted Comparative 3D Structure on Q8IUR7
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC032661 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:45133 IMAGE:5530425), complete cds.AK296757 - Homo sapiens cDNA FLJ56387 complete cds, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA.AK299769 - Homo sapiens cDNA FLJ53383 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.AK304558 - Homo sapiens cDNA FLJ54248 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.AK296837 - Homo sapiens cDNA FLJ55707 complete cds, highly similar to Mus musculus armadillo repeat containing 8 (Armc8), mRNA.BC041699 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:48800 IMAGE:5240423), complete cds.AK001721 - Homo sapiens cDNA FLJ10859 fis, clone NT2RP4001567, weakly similar to ARMADILLO SEGMENT POLARITY PROTEIN.AK315932 - Homo sapiens cDNA, FLJ78831 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.AK299229 - Homo sapiens cDNA FLJ56232 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 2, mRNA.AK001882 - Homo sapiens cDNA FLJ11020 fis, clone PLACE1003625, weakly similar to ARMADILLO SEGMENT POLARITY PROTEIN.AF161541 - Homo sapiens HSPC056 mRNA, complete cds.BC013424 - Homo sapiens armadillo repeat containing 8, mRNA (cDNA clone MGC:10058 IMAGE:3892143), complete cds.AF109184 - Homo sapiens S863-2 mRNA, complete cds.AK289577 - Homo sapiens cDNA FLJ76733 complete cds, highly similar to Homo sapiens armadillo repeat containing 8 (ARMC8), transcript variant 1, mRNA.JD449842 - Sequence 430866 from Patent EP1572962.BC007934 - Homo sapiens cDNA clone IMAGE:4127359, **** WARNING: chimeric clone ****.CU680606 - Synthetic construct Homo sapiens gateway clone IMAGE:100017148 5' read ARMC8 mRNA.HQ448218 - Synthetic construct Homo sapiens clone IMAGE:100071619; CCSB003107_01 armadillo repeat containing 8 (ARMC8) gene, encodes complete protein.KJ893478 - Synthetic construct Homo sapiens clone ccsbBroadEn_02872 ARMC8 gene, encodes complete protein.AK098500 - Homo sapiens cDNA FLJ25634 fis, clone STM04154.JD536010 - Sequence 517034 from Patent EP1572962.JD356829 - Sequence 337853 from Patent EP1572962.JD240620 - Sequence 221644 from Patent EP1572962.JD176635 - Sequence 157659 from Patent EP1572962.JD530114 - Sequence 511138 from Patent EP1572962.JD394561 - Sequence 375585 from Patent EP1572962.JD141266 - Sequence 122290 from Patent EP1572962.JD096056 - Sequence 77080 from Patent EP1572962.JD385794 - Sequence 366818 from Patent EP1572962.JD176623 - Sequence 157647 from Patent EP1572962.JD260786 - Sequence 241810 from Patent EP1572962.JD113154 - Sequence 94178 from Patent EP1572962.JD339729 - Sequence 320753 from Patent EP1572962.JD136038 - Sequence 117062 from Patent EP1572962.JD240497 - Sequence 221521 from Patent EP1572962.JD386175 - Sequence 367199 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A8K0L2, ARMC8_HUMAN, BC013424, D3DNE6, ENST00000471453.1, ENST00000471453.2, ENST00000471453.3, ENST00000471453.4, Q6PIL2, Q8IUR7, Q96D19, Q96HZ5, Q9NV02, Q9NV94, Q9Y4R9, S863-2, uc003erw.1, uc003erw.2, uc003erw.3, uc003erw.4, uc003erw.5, uc003erw.6UCSC ID: ENST00000471453.5RefSeq Accession: NM_014154
Protein: Q8IUR7
(aka ARMC8_HUMAN)
CCDS: CCDS3098.1
Methods, Credits, and Use Restrictions
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