Human Gene RBP2 (ENST00000232217.6) from GENCODE V44
Description: Homo sapiens retinol binding protein 2 (RBP2), mRNA. (from RefSeq NM_004164) RefSeq Summary (NM_004164): This gene encodes an abundant protein present in the small intestinal epithelium. It is thought to participate in the uptake and/or intracellular metabolism of vitamin A. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. This protein may also modulate the supply of retinoic acid to the nuclei of endometrial cells during the menstrual cycle. [provided by RefSeq, Aug 2015]. Gencode Transcript: ENST00000232217.6 Gencode Gene: ENSG00000114113.6 Transcript (Including UTRs) Position: hg38 chr3:139,452,884-139,476,516 Size: 23,633 Total Exon Count: 4 Strand: - Coding Region Position: hg38 chr3:139,453,116-139,476,459 Size: 23,344 Coding Exon Count: 4
ID:RET2_HUMAN DESCRIPTION: RecName: Full=Retinol-binding protein 2; AltName: Full=Cellular retinol-binding protein II; Short=CRBP-II; FUNCTION: Intracellular transport of retinol. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Higher expression in adult small intestine and to a much lesser extent in fetal kidney. DOMAIN: Forms a beta-barrel structure that accommodates hydrophobic ligands in its interior. SIMILARITY: Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P50120
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.