Human Gene MME (ENST00000460393.6) from GENCODE V44
Description: Homo sapiens membrane metalloendopeptidase (MME), transcript variant 1, mRNA. (from RefSeq NM_000902) RefSeq Summary (NM_000902): The protein encoded by this gene is a type II transmembrane glycoprotein and a common acute lymphocytic leukemia antigen that is an important cell surface marker in the diagnosis of human acute lymphocytic leukemia (ALL). The encoded protein is present on leukemic cells of pre-B phenotype, which represent 85% of cases of ALL. This protein is not restricted to leukemic cells, however, and is found on a variety of normal tissues. The protein is a neutral endopeptidase that cleaves peptides at the amino side of hydrophobic residues and inactivates several peptide hormones including glucagon, enkephalins, substance P, neurotensin, oxytocin, and bradykinin. [provided by RefSeq, Aug 2017]. Gencode Transcript: ENST00000460393.6 Gencode Gene: ENSG00000196549.13 Transcript (Including UTRs) Position: hg38 chr3:155,079,672-155,183,704 Size: 104,033 Total Exon Count: 23 Strand: + Coding Region Position: hg38 chr3:155,084,168-155,180,459 Size: 96,292 Coding Exon Count: 22
ID:NEP_HUMAN DESCRIPTION: RecName: Full=Neprilysin; EC=3.4.24.11; AltName: Full=Atriopeptidase; AltName: Full=Common acute lymphocytic leukemia antigen; Short=CALLA; AltName: Full=Enkephalinase; AltName: Full=Neutral endopeptidase 24.11; Short=NEP; Short=Neutral endopeptidase; AltName: Full=Skin fibroblast elastase; Short=SFE; AltName: CD_antigen=CD10; FUNCTION: Thermolysin-like specificity, but is almost confined on acting on polypeptides of up to 30 amino acids. Biologically important in the destruction of opioid peptides such as Met- and Leu-enkephalins by cleavage of a Gly-Phe bond. Able to cleave angiotensin-1, angiotensin-2 and angiotensin 1-9. Involved in the degradation of atrial natriuretic factor (ANF). Displays UV- inducible elastase activity toward skin preelastic and elastic fibers. CATALYTIC ACTIVITY: Preferential cleavage of polypeptides between hydrophobic residues, particularly with Phe or Tyr at P1'. COFACTOR: Binds 1 zinc ion per subunit. ENZYME REGULATION: Inhibited in a dose dependent manner by opiorphin. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=55.1 uM for angiotensin-1; KM=179 uM for angiotensin-2; KM=111.4 uM for angiotensin 1-9; INTERACTION: P08107:HSPA1B; NbExp=3; IntAct=EBI-353759, EBI-629985; P04792:HSPB1; NbExp=4; IntAct=EBI-353759, EBI-352682; SUBCELLULAR LOCATION: Cell membrane; Single-pass type II membrane protein. PTM: Myristoylation is a determinant of membrane targeting. MISCELLANEOUS: Important cell surface marker in the diagnostic of human acute lymphocytic leukemia. SIMILARITY: Belongs to the peptidase M13 family. SEQUENCE CAUTION: Sequence=CAA30157.1; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/MMEID41386ch3q25.html";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P08473
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
