Human Gene CHRD (ENST00000448472.5) from GENCODE V44
Description: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). (from UniProt Q9H2X0) RefSeq Summary (NM_003741): This gene encodes a secreted protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta-like bone morphogenetic proteins and sequestering them in latent complexes. The encoded protein may also have roles in organogenesis and during adulthood. It has been suggested that this gene could be a candidate gene for Cornelia de Lange syndrome. Reduced expression of this gene results in enhanced bone regeneration. Alternative splicing results in multiple transcript variants. Other alternative splice variants have been described but their full length sequence has not been determined. [provided by RefSeq, Jan 2015]. Gencode Transcript: ENST00000448472.5 Gencode Gene: ENSG00000090539.16 Transcript (Including UTRs) Position: hg38 chr3:184,380,073-184,389,829 Size: 9,757 Total Exon Count: 24 Strand: + Coding Region Position: hg38 chr3:184,380,319-184,381,108 Size: 790 Coding Exon Count: 3
ID:CHRD_HUMAN DESCRIPTION: RecName: Full=Chordin; Flags: Precursor; FUNCTION: Dorsalizing factor. Key developmental protein that dorsalizes early vertebrate embryonic tissues by binding to ventralizing TGF-beta family bone morphogenetic proteins (BMPs) and sequestering them in latent complexes (By similarity). SUBUNIT: Interacts with TWSG1 and/or BMP4 (By similarity). INTERACTION: P84022:SMAD3; NbExp=2; IntAct=EBI-947551, EBI-347161; SUBCELLULAR LOCATION: Secreted (By similarity). TISSUE SPECIFICITY: Expressed at the highest level in liver. PTM: Cleaved by tolloid proteases; cleavage participates in dorsoventral patterning during early development (By similarity). SIMILARITY: Belongs to the chordin family. SIMILARITY: Contains 4 CHRD domains. SIMILARITY: Contains 4 VWFC domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF07452 - CHRD domain PF00093 - von Willebrand factor type C domain
ModBase Predicted Comparative 3D Structure on Q9H2X0
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001501 skeletal system development GO:0001649 osteoblast differentiation GO:0001702 gastrulation with mouth forming second GO:0001707 mesoderm formation GO:0002053 positive regulation of mesenchymal cell proliferation GO:0007275 multicellular organism development GO:0007389 pattern specification process GO:0007417 central nervous system development GO:0009953 dorsal/ventral pattern formation GO:0021919 BMP signaling pathway involved in spinal cord dorsal/ventral patterning GO:0030336 negative regulation of cell migration GO:0030514 negative regulation of BMP signaling pathway GO:0030900 forebrain development GO:0033504 floor plate development GO:0045668 negative regulation of osteoblast differentiation GO:0045785 positive regulation of cell adhesion
Cellular Component: GO:0005576 extracellular region GO:0005615 extracellular space
Descriptions from all associated GenBank mRNAs
LF213803 - JP 2014500723-A/21306: Polycomb-Associated Non-Coding RNAs. MA449380 - JP 2018138019-A/21306: Polycomb-Associated Non-Coding RNAs. LF212670 - JP 2014500723-A/20173: Polycomb-Associated Non-Coding RNAs. MA448247 - JP 2018138019-A/20173: Polycomb-Associated Non-Coding RNAs. LF212672 - JP 2014500723-A/20175: Polycomb-Associated Non-Coding RNAs. MA448249 - JP 2018138019-A/20175: Polycomb-Associated Non-Coding RNAs. AF209929 - Homo sapiens chordin variant 1 (CHRD) mRNA, complete cds, alternatively spliced. AF209928 - Homo sapiens chordin (CHRD) mRNA, complete cds, alternatively spliced. AF209930 - Homo sapiens chordin variant 2 (CHRD) mRNA, complete cds, alternatively spliced. AF283325 - Homo sapiens chordin variant 3 (CHRD) mRNA, complete cds, alternatively spliced. AY358926 - Homo sapiens clone DNA35917 chordin (UNQ217) mRNA, complete cds. BC112345 - Homo sapiens chordin, transcript variant 1, mRNA (cDNA clone MGC:133038 IMAGE:40008417), complete cds. LF210557 - JP 2014500723-A/18060: Polycomb-Associated Non-Coding RNAs. MA446134 - JP 2018138019-A/18060: Polycomb-Associated Non-Coding RNAs. AB208947 - Homo sapiens mRNA for chordin isoform a variant protein. AK074147 - Homo sapiens mRNA for FLJ00220 protein. AK293456 - Homo sapiens cDNA FLJ50077 complete cds, highly similar to Chordin precursor. AK295632 - Homo sapiens cDNA FLJ60564 complete cds, highly similar to Chordin precursor. AK296316 - Homo sapiens cDNA FLJ53797 complete cds, highly similar to Chordin precursor. LF213384 - JP 2014500723-A/20887: Polycomb-Associated Non-Coding RNAs. MA448961 - JP 2018138019-A/20887: Polycomb-Associated Non-Coding RNAs. JD514593 - Sequence 495617 from Patent EP1572962. LF338789 - JP 2014500723-A/146292: Polycomb-Associated Non-Coding RNAs. MA574366 - JP 2018138019-A/146292: Polycomb-Associated Non-Coding RNAs. JD069287 - Sequence 50311 from Patent EP1572962. AF076612 - Homo sapiens chordin (CHRD) mRNA, partial cds. JD164436 - Sequence 145460 from Patent EP1572962. JD258730 - Sequence 239754 from Patent EP1572962. JD086253 - Sequence 67277 from Patent EP1572962. JD414083 - Sequence 395107 from Patent EP1572962. JD531952 - Sequence 512976 from Patent EP1572962. AK300213 - Homo sapiens cDNA FLJ54880 complete cds, moderately similar to Chordin precursor. JD462749 - Sequence 443773 from Patent EP1572962. JD475848 - Sequence 456872 from Patent EP1572962. JD077241 - Sequence 58265 from Patent EP1572962. JD288033 - Sequence 269057 from Patent EP1572962. JD547891 - Sequence 528915 from Patent EP1572962. JD104346 - Sequence 85370 from Patent EP1572962. JD372443 - Sequence 353467 from Patent EP1572962. JD118222 - Sequence 99246 from Patent EP1572962. JD174653 - Sequence 155677 from Patent EP1572962. JD060587 - Sequence 41611 from Patent EP1572962. JD158274 - Sequence 139298 from Patent EP1572962. JD541396 - Sequence 522420 from Patent EP1572962. JD498447 - Sequence 479471 from Patent EP1572962. JD515899 - Sequence 496923 from Patent EP1572962. JD221740 - Sequence 202764 from Patent EP1572962. JD534051 - Sequence 515075 from Patent EP1572962. AK300476 - Homo sapiens cDNA FLJ54312 complete cds, highly similar to Chordin precursor. JD231662 - Sequence 212686 from Patent EP1572962. JD446818 - Sequence 427842 from Patent EP1572962. JD229940 - Sequence 210964 from Patent EP1572962. JD115290 - Sequence 96314 from Patent EP1572962. JD363829 - Sequence 344853 from Patent EP1572962. JD052870 - Sequence 33894 from Patent EP1572962. JD111817 - Sequence 92841 from Patent EP1572962. JD157590 - Sequence 138614 from Patent EP1572962. JD186080 - Sequence 167104 from Patent EP1572962. BC029879 - Homo sapiens, clone IMAGE:5175884, mRNA, partial cds. AF038198 - Homo sapiens clone 23928 mRNA sequence. JD370668 - Sequence 351692 from Patent EP1572962. JD100535 - Sequence 81559 from Patent EP1572962. JD273968 - Sequence 254992 from Patent EP1572962. JD044710 - Sequence 25734 from Patent EP1572962. JD074617 - Sequence 55641 from Patent EP1572962. JD474181 - Sequence 455205 from Patent EP1572962. JD185708 - Sequence 166732 from Patent EP1572962. JD384212 - Sequence 365236 from Patent EP1572962. JD338071 - Sequence 319095 from Patent EP1572962. JD416216 - Sequence 397240 from Patent EP1572962. LF338790 - JP 2014500723-A/146293: Polycomb-Associated Non-Coding RNAs. MA574367 - JP 2018138019-A/146293: Polycomb-Associated Non-Coding RNAs. JD269308 - Sequence 250332 from Patent EP1572962. JD339831 - Sequence 320855 from Patent EP1572962. JD136748 - Sequence 117772 from Patent EP1572962. JD390137 - Sequence 371161 from Patent EP1572962. JD501565 - Sequence 482589 from Patent EP1572962. JD248267 - Sequence 229291 from Patent EP1572962. JD560125 - Sequence 541149 from Patent EP1572962. JD190667 - Sequence 171691 from Patent EP1572962. JD098242 - Sequence 79266 from Patent EP1572962. JD324716 - Sequence 305740 from Patent EP1572962. JD248523 - Sequence 229547 from Patent EP1572962. JD067618 - Sequence 48642 from Patent EP1572962.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04350 - TGF-beta signaling pathway
BioCarta from NCI Cancer Genome Anatomy Project h_alkPathway - ALK in cardiac myocytes