Human Gene MAN2B2 (ENST00000285599.8) from GENCODE V44
Description: Homo sapiens mannosidase alpha class 2B member 2 (MAN2B2), transcript variant 1, mRNA. (from RefSeq NM_015274)
Gencode Transcript: ENST00000285599.8
Gencode Gene: ENSG00000013288.9
Transcript (Including UTRs)
Position: hg38 chr4:6,575,189-6,623,362 Size: 48,174 Total Exon Count: 19 Strand: +
Coding Region
Position: hg38 chr4:6,575,211-6,621,285 Size: 46,075 Coding Exon Count: 19
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MA2B2_HUMAN
DESCRIPTION: RecName: Full=Epididymis-specific alpha-mannosidase; EC=3.2.1.24; AltName: Full=Mannosidase alpha class 2B member 2; Flags: Precursor;
CATALYTIC ACTIVITY: Hydrolysis of terminal, non-reducing alpha-D- mannose residues in alpha-D-mannosides.COFACTOR: Binds 1 zinc ion per subunit (By similarity).SUBCELLULAR LOCATION: Secreted (Potential).SIMILARITY: Belongs to the glycosyl hydrolase 38 family.
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR011013 - Glyco_hydro-type_carb-bd
IPR011330 - Glyco_hydro/deAcase_b/a-brl
IPR013780 - Glyco_hydro_13_b
IPR011682 - Glyco_hydro_38_C
IPR015341 - Glyco_hydro_38_cen_dom
IPR000602 - Glyco_hydro_38_core
Pfam Domains: PF09261 - Alpha mannosidase middle domain
PF01074 - Glycosyl hydrolases family 38 N-terminal domain
PF07748 - Glycosyl hydrolases family 38 C-terminal domain
ModBase Predicted Comparative 3D Structure on Q9Y2E5
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF206820 - JP 2014500723-A/14323: Polycomb-Associated Non-Coding RNAs.MA442397 - JP 2018138019-A/14323: Polycomb-Associated Non-Coding RNAs.BC094773 - Homo sapiens mannosidase, alpha, class 2B, member 2, mRNA (cDNA clone MGC:104672 IMAGE:30531368), complete cds.AK301473 - Homo sapiens cDNA FLJ61716 complete cds, highly similar to Epididymis-specific alpha-mannosidase precursor(EC 3.2.1.24).JD193911 - Sequence 174935 from Patent EP1572962.JD271251 - Sequence 252275 from Patent EP1572962.AL832232 - Homo sapiens mRNA; cDNA DKFZp686F0253 (from clone DKFZp686F0253).AL833071 - Homo sapiens mRNA; cDNA DKFZp451A0519 (from clone DKFZp451A0519); complete cds.BC033307 - Homo sapiens mannosidase, alpha, class 2B, member 2, mRNA (cDNA clone MGC:24942 IMAGE:4932398), complete cds.GQ891475 - Homo sapiens clone HEL-S-196 epididymis secretory sperm binding protein mRNA, complete cds.KJ898474 - Synthetic construct Homo sapiens clone ccsbBroadEn_07868 MAN2B2-like gene, encodes complete protein.AB023152 - Homo sapiens mRNA for KIAA0935 protein, partial cds.LF358263 - JP 2014500723-A/165766: Polycomb-Associated Non-Coding RNAs.MA593840 - JP 2018138019-A/165766: Polycomb-Associated Non-Coding RNAs.LF358262 - JP 2014500723-A/165765: Polycomb-Associated Non-Coding RNAs.MA593839 - JP 2018138019-A/165765: Polycomb-Associated Non-Coding RNAs.AK025803 - Homo sapiens cDNA: FLJ22150 fis, clone HRC00109.LF358261 - JP 2014500723-A/165764: Polycomb-Associated Non-Coding RNAs.MA593838 - JP 2018138019-A/165764: Polycomb-Associated Non-Coding RNAs.BC036836 - Homo sapiens mannosidase, alpha, class 2B, member 2, mRNA (cDNA clone IMAGE:4993533), complete cds.LF358260 - JP 2014500723-A/165763: Polycomb-Associated Non-Coding RNAs.MA593837 - JP 2018138019-A/165763: Polycomb-Associated Non-Coding RNAs.AK075246 - Homo sapiens cDNA FLJ90765 fis, clone THYRO1000584, highly similar to Epididymis-specific alpha-mannosidase precursor (EC 3.2.1.24).LF358259 - JP 2014500723-A/165762: Polycomb-Associated Non-Coding RNAs.MA593836 - JP 2018138019-A/165762: Polycomb-Associated Non-Coding RNAs.LF358256 - JP 2014500723-A/165759: Polycomb-Associated Non-Coding RNAs.MA593833 - JP 2018138019-A/165759: Polycomb-Associated Non-Coding RNAs.JD296540 - Sequence 277564 from Patent EP1572962.JD308031 - Sequence 289055 from Patent EP1572962.JD112578 - Sequence 93602 from Patent EP1572962.JD490805 - Sequence 471829 from Patent EP1572962.JD481942 - Sequence 462966 from Patent EP1572962.LF358255 - JP 2014500723-A/165758: Polycomb-Associated Non-Coding RNAs.MA593832 - JP 2018138019-A/165758: Polycomb-Associated Non-Coding RNAs.JD353544 - Sequence 334568 from Patent EP1572962.JD260994 - Sequence 242018 from Patent EP1572962.JD104425 - Sequence 85449 from Patent EP1572962.JD103348 - Sequence 84372 from Patent EP1572962.JD039282 - Sequence 20306 from Patent EP1572962.JD049354 - Sequence 30378 from Patent EP1572962.JD531020 - Sequence 512044 from Patent EP1572962.JD420522 - Sequence 401546 from Patent EP1572962.JD189160 - Sequence 170184 from Patent EP1572962.JD373880 - Sequence 354904 from Patent EP1572962.JD224750 - Sequence 205774 from Patent EP1572962.JD318343 - Sequence 299367 from Patent EP1572962.JD352572 - Sequence 333596 from Patent EP1572962.JD524775 - Sequence 505799 from Patent EP1572962.JD414570 - Sequence 395594 from Patent EP1572962.JD337754 - Sequence 318778 from Patent EP1572962.JD463315 - Sequence 444339 from Patent EP1572962.JD426724 - Sequence 407748 from Patent EP1572962.JD286934 - Sequence 267958 from Patent EP1572962.JD067421 - Sequence 48445 from Patent EP1572962.JD397764 - Sequence 378788 from Patent EP1572962.JD416241 - Sequence 397265 from Patent EP1572962.JD242708 - Sequence 223732 from Patent EP1572962.JD330999 - Sequence 312023 from Patent EP1572962.JD287300 - Sequence 268324 from Patent EP1572962.JD341818 - Sequence 322842 from Patent EP1572962.JD479569 - Sequence 460593 from Patent EP1572962.JD395012 - Sequence 376036 from Patent EP1572962.JD560671 - Sequence 541695 from Patent EP1572962.JD476692 - Sequence 457716 from Patent EP1572962.JD414729 - Sequence 395753 from Patent EP1572962.JD120507 - Sequence 101531 from Patent EP1572962.JD379589 - Sequence 360613 from Patent EP1572962.JD094075 - Sequence 75099 from Patent EP1572962.JD311554 - Sequence 292578 from Patent EP1572962.JD356269 - Sequence 337293 from Patent EP1572962.JD505683 - Sequence 486707 from Patent EP1572962.JD553757 - Sequence 534781 from Patent EP1572962.JD544510 - Sequence 525534 from Patent EP1572962.JD371060 - Sequence 352084 from Patent EP1572962.JD355351 - Sequence 336375 from Patent EP1572962.JD330030 - Sequence 311054 from Patent EP1572962.JD324000 - Sequence 305024 from Patent EP1572962.JD483471 - Sequence 464495 from Patent EP1572962.JD232030 - Sequence 213054 from Patent EP1572962.JD279562 - Sequence 260586 from Patent EP1572962.JD489434 - Sequence 470458 from Patent EP1572962.JD500064 - Sequence 481088 from Patent EP1572962.JD288490 - Sequence 269514 from Patent EP1572962.JD148383 - Sequence 129407 from Patent EP1572962.JD463900 - Sequence 444924 from Patent EP1572962.JD478652 - Sequence 459676 from Patent EP1572962.JD279210 - Sequence 260234 from Patent EP1572962.JD223335 - Sequence 204359 from Patent EP1572962.JD286822 - Sequence 267846 from Patent EP1572962.JD511607 - Sequence 492631 from Patent EP1572962.JD319922 - Sequence 300946 from Patent EP1572962.JD319923 - Sequence 300947 from Patent EP1572962.JD319924 - Sequence 300948 from Patent EP1572962.JD376771 - Sequence 357795 from Patent EP1572962.JD411971 - Sequence 392995 from Patent EP1572962.JD257010 - Sequence 238034 from Patent EP1572962.JD441598 - Sequence 422622 from Patent EP1572962.JD329546 - Sequence 310570 from Patent EP1572962.JD172917 - Sequence 153941 from Patent EP1572962.JD321982 - Sequence 303006 from Patent EP1572962.JD398227 - Sequence 379251 from Patent EP1572962.JD417051 - Sequence 398075 from Patent EP1572962.JD520394 - Sequence 501418 from Patent EP1572962.JD129276 - Sequence 110300 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000285599.1, ENST00000285599.2, ENST00000285599.3, ENST00000285599.4, ENST00000285599.5, ENST00000285599.6, ENST00000285599.7, KIAA0935, MA2B2_HUMAN, NM_015274, Q66MP2, Q86T67, Q9Y2E5, uc003gjf.1, uc003gjf.2, uc003gjf.3UCSC ID: ENST00000285599.8RefSeq Accession: NM_015274
Protein: Q9Y2E5
(aka MA2B2_HUMAN or M2B2_HUMAN)
CCDS: CCDS33951.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.