Human Gene RPL9 (ENST00000449470.6) from GENCODE V44
  Description: ribosomal protein L9 (from HGNC RPL9)
RefSeq Summary (NM_001024921): Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L6P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016].
Gencode Transcript: ENST00000449470.6
Gencode Gene: ENSG00000163682.17
Transcript (Including UTRs)
   Position: hg38 chr4:39,454,137-39,458,888 Size: 4,752 Total Exon Count: 7 Strand: -
Coding Region
   Position: hg38 chr4:39,454,543-39,458,439 Size: 3,897 Coding Exon Count: 6 

Page IndexSequence and LinksPrimersCTDRNA-Seq ExpressionMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr4:39,454,137-39,458,888)mRNA (may differ from genome)Protein (192 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblExonPrimerGencodeGeneCardsHGNC
LynxMalacardsMGIPubMedUniProtKBWikipedia

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 203.09 RPKM in Ovary
Total median expression: 3517.45 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -188.00449-0.419 Picture PostScript Text
3' UTR -15.4099-0.156 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR000702 - Ribosomal_L6
IPR020040 - Ribosomal_L6_a/b-dom
IPR002359 - Ribosomal_L6_CS2

Pfam Domains:
PF00347 - Ribosomal protein L6

ModBase Predicted Comparative 3D Structure on Q53Z07
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologGenome BrowserGenome BrowserGenome Browser
Gene Details    Gene Details
Gene Sorter    Gene Sorter
MGIRGDEnsemblEnsemblWormBaseSGD
Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence
AlignmentAlignmentAlignmentAlignmentAlignmentAlignment

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003735 structural constituent of ribosome
GO:0019843 rRNA binding

Biological Process:
GO:0006412 translation

Cellular Component:
GO:0005622 intracellular
GO:0005840 ribosome


-  Descriptions from all associated GenBank mRNAs
  BC031906 - Homo sapiens ribosomal protein L9, mRNA (cDNA clone MGC:29903 IMAGE:4996986), complete cds.
AL832047 - Homo sapiens mRNA; cDNA DKFZp313J1510 (from clone DKFZp313J1510).
D14531 - Homo sapiens mRNA for rat ribosomal protein L9 homologue, complete cds.
U09953 - Human ribosomal protein L9 mRNA, complete cds.
BC004156 - Homo sapiens ribosomal protein L9, mRNA (cDNA clone MGC:2418 IMAGE:2961026), complete cds.
BC004206 - Homo sapiens ribosomal protein L9, mRNA (cDNA clone MGC:4066 IMAGE:2961026), complete cds.
U21138 - Human ribosomal protein L9 mRNA, complete cds.
BC100285 - Homo sapiens ribosomal protein L9, mRNA (cDNA clone MGC:117341 IMAGE:6022858), complete cds.
AY376242 - Homo sapiens ribosomal protein L9 isoform mRNA, complete cds.
BC000483 - Homo sapiens ribosomal protein L9, mRNA (cDNA clone MGC:8704 IMAGE:2964733), complete cds.
BC066318 - Homo sapiens ribosomal protein L9, mRNA (cDNA clone MGC:87207 IMAGE:5277491), complete cds.
LF210608 - JP 2014500723-A/18111: Polycomb-Associated Non-Coding RNAs.
MA446185 - JP 2018138019-A/18111: Polycomb-Associated Non-Coding RNAs.
AB062431 - Homo sapiens OK/SW-cl.103 mRNA for ribosomal protein L9, complete cds.
AK130966 - Homo sapiens cDNA FLJ27456 fis, clone TST99901, highly similar to 60S ribosomal protein L9.
AY320412 - Homo sapiens nasopharyngeal carcinoma-associated antigen NPC-A-16 mRNA, complete cds.
AY597415 - Homo sapiens chromosome 15 carcinoma associated antigen CRC-L-10 mRNA sequence.
LF339234 - JP 2014500723-A/146737: Polycomb-Associated Non-Coding RNAs.
MA574811 - JP 2018138019-A/146737: Polycomb-Associated Non-Coding RNAs.
JD190153 - Sequence 171177 from Patent EP1572962.
LF376973 - JP 2014500723-A/184476: Polycomb-Associated Non-Coding RNAs.
MA612550 - JP 2018138019-A/184476: Polycomb-Associated Non-Coding RNAs.
LF208489 - JP 2014500723-A/15992: Polycomb-Associated Non-Coding RNAs.
MA444066 - JP 2018138019-A/15992: Polycomb-Associated Non-Coding RNAs.
JD019249 - Sequence 273 from Patent EP1572962.
JD035736 - Sequence 16760 from Patent EP1572962.
LF206853 - JP 2014500723-A/14356: Polycomb-Associated Non-Coding RNAs.
MA442430 - JP 2018138019-A/14356: Polycomb-Associated Non-Coding RNAs.
AK312241 - Homo sapiens cDNA, FLJ92535, Homo sapiens ribosomal protein L9 (RPL9), mRNA.
DQ892727 - Synthetic construct clone IMAGE:100005357; FLH189153.01X; RZPDo839C0274D ribosomal protein L9 (RPL9) gene, encodes complete protein.
DQ892959 - Synthetic construct Homo sapiens clone IMAGE:100005589; FLH263532.01X; RZPDo839A0577D ribosomal protein L9 (RPL9) gene, encodes complete protein.
KJ892026 - Synthetic construct Homo sapiens clone ccsbBroadEn_01420 RPL9 gene, encodes complete protein.
DQ895974 - Synthetic construct Homo sapiens clone IMAGE:100010434; FLH189149.01L; RZPDo839C0264D ribosomal protein L9 (RPL9) gene, encodes complete protein.
AB529031 - Synthetic construct DNA, clone: pF1KB3429, Homo sapiens RPL9 gene for ribosomal protein L9, without stop codon, in Flexi system.
LF358632 - JP 2014500723-A/166135: Polycomb-Associated Non-Coding RNAs.
MA594209 - JP 2018138019-A/166135: Polycomb-Associated Non-Coding RNAs.
DQ592209 - Homo sapiens piRNA piR-59321, complete sequence.
LF376972 - JP 2014500723-A/184475: Polycomb-Associated Non-Coding RNAs.
MA612549 - JP 2018138019-A/184475: Polycomb-Associated Non-Coding RNAs.
LF358633 - JP 2014500723-A/166136: Polycomb-Associated Non-Coding RNAs.
MA594210 - JP 2018138019-A/166136: Polycomb-Associated Non-Coding RNAs.
AK297178 - Homo sapiens cDNA FLJ51990 complete cds, highly similar to 60S ribosomal protein L9.
DL492354 - Novel nucleic acids.
DL490843 - Novel nucleic acids.
LF358636 - JP 2014500723-A/166139: Polycomb-Associated Non-Coding RNAs.
MA594213 - JP 2018138019-A/166139: Polycomb-Associated Non-Coding RNAs.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03010 - Ribosome

-  Other Names for This Gene
  Alternate Gene Symbols: AY376242, ENST00000449470.1, ENST00000449470.2, ENST00000449470.3, ENST00000449470.4, ENST00000449470.5, hCG_37461, Q53Z07, Q53Z07_HUMAN, uc003gub.1, uc003gub.2, uc003gub.3, uc003gub.4
UCSC ID: ENST00000449470.6
RefSeq Accession: NM_001024921
Protein: Q53Z07 CCDS: CCDS3452.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.