Human Gene CXCL8 (ENST00000307407.8) from GENCODE V44
Description: Homo sapiens C-X-C motif chemokine ligand 8 (CXCL8), transcript variant 1, mRNA. (from RefSeq NM_000584) RefSeq Summary (NM_000584): The protein encoded by this gene is a member of the CXC chemokine family and is a major mediator of the inflammatory response. The encoded protein is commonly referred to as interleukin-8 (IL-8). IL-8 is secreted by mononuclear macrophages, neutrophils, eosinophils, T lymphocytes, epithelial cells, and fibroblasts. It functions as a chemotactic factor by guiding the neutrophils to the site of infection. Bacterial and viral products rapidly induce IL-8 expression. IL-8 also participates with other cytokines in the proinflammatory signaling cascade and plays a role in systemic inflammatory response syndrome (SIRS). This gene is believed to play a role in the pathogenesis of the lower respiratory tract infection bronchiolitis, a common respiratory tract disease caused by the respiratory syncytial virus (RSV). The overproduction of this proinflammatory protein is thought to cause the lung inflammation associated with csytic fibrosis. This proinflammatory protein is also suspected of playing a role in coronary artery disease and endothelial dysfunction. This protein is also secreted by tumor cells and promotes tumor migration, invasion, angiogenesis and metastasis. This chemokine is also a potent angiogenic factor. The binding of IL-8 to one of its receptors (IL-8RB/CXCR2) increases the permeability of blood vessels and increasing levels of IL-8 are positively correlated with increased severity of multiple disease outcomes (eg, sepsis). This gene and other members of the CXC chemokine gene family form a gene cluster in a region of chromosome 4q. [provided by RefSeq, May 2020]. Gencode Transcript: ENST00000307407.8 Gencode Gene: ENSG00000169429.12 Transcript (Including UTRs) Position: hg38 chr4:73,740,569-73,743,716 Size: 3,148 Total Exon Count: 4 Strand: + Coding Region Position: hg38 chr4:73,740,659-73,742,464 Size: 1,806 Coding Exon Count: 4
ID:IL8_HUMAN DESCRIPTION: RecName: Full=Interleukin-8; Short=IL-8; AltName: Full=C-X-C motif chemokine 8; AltName: Full=Emoctakin; AltName: Full=Granulocyte chemotactic protein 1; Short=GCP-1; AltName: Full=Monocyte-derived neutrophil chemotactic factor; Short=MDNCF; AltName: Full=Monocyte-derived neutrophil-activating peptide; Short=MONAP; AltName: Full=Neutrophil-activating protein 1; Short=NAP-1; AltName: Full=Protein 3-10C; AltName: Full=T-cell chemotactic factor; Contains: RecName: Full=MDNCF-a; AltName: Full=GCP/IL-8 protein IV; AltName: Full=IL8/NAP1 form I; Contains: RecName: Full=Interleukin-8; AltName: Full=(Ala-IL-8)77; AltName: Full=GCP/IL-8 protein II; AltName: Full=IL-8(1-77); AltName: Full=IL8/NAP1 form II; AltName: Full=MDNCF-b; Contains: RecName: Full=IL-8(5-77); Contains: RecName: Full=IL-8(6-77); AltName: Full=(Ser-IL-8)72; AltName: Full=GCP/IL-8 protein I; AltName: Full=IL8/NAP1 form III; AltName: Full=Lymphocyte-derived neutrophil-activating factor; Short=LYNAP; AltName: Full=MDNCF-c; AltName: Full=Neutrophil-activating factor; Short=NAF; Contains: RecName: Full=IL-8(7-77); AltName: Full=GCP/IL-8 protein V; AltName: Full=IL8/NAP1 form IV; Contains: RecName: Full=IL-8(8-77); AltName: Full=GCP/IL-8 protein VI; AltName: Full=IL8/NAP1 form V; Contains: RecName: Full=IL-8(9-77); AltName: Full=GCP/IL-8 protein III; AltName: Full=IL8/NAP1 form VI; Flags: Precursor; FUNCTION: IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus. IL-8(6-77) has a 5-10-fold higher activity on neutrophil activation, IL-8(5-77) has increased activity on neutrophil activation and IL-8(7-77) has a higher affinity to receptors CXCR1 and CXCR2 as compared to IL-8(1-77), respectively. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Secreted. INDUCTION: By ER stress in a DDIT3/CHOP-dependent manner. PTM: Several N-terminal processed forms are produced by proteolytic cleavage after secretion from at least peripheral blood monocytes, leukcocytes and endothelial cells. In general, IL-8(1-77) is referred to as interleukin-8. IL-8(6-77) is the most promiment form. SIMILARITY: Belongs to the intercrine alpha (chemokine CxC) family. WEB RESOURCE: Name=Wikipedia; Note=Interleukin-8 entry; URL="http://en.wikipedia.org/wiki/Interleukin_8"; WEB RESOURCE: Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/il8/";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P10145
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
BioCarta from NCI Cancer Genome Anatomy Project h_freePathway - Free Radical Induced Apoptosis h_pepiPathway - Proepithelin Conversion to Epithelin and Wound Repair Control h_cytokinePathway - Cytokine Network h_il17Pathway - IL 17 Signaling Pathway h_inflamPathway - Cytokines and Inflammatory Response h_granulocytesPathway - Adhesion and Diapedesis of Granulocytes h_stemPathway - Regulation of hematopoiesis by cytokines h_LairPathway - Cells and Molecules involved in local acute inflammatory response h_lympathway - Adhesion and Diapedesis of Lymphocytes h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae
Reactome (by CSHL, EBI, and GO)
Protein P10145 (Reactome details) participates in the following event(s):
US Server
Sequence and Links to Tools and Databases 
Microarray Expression Data 
