Human Gene PF4V1 (ENST00000226524.4) from GENCODE V44
Description: Homo sapiens platelet factor 4 variant 1 (PF4V1), mRNA. (from RefSeq NM_002620) RefSeq Summary (NM_002620): The protein encoded by this gene is a chemokine that is highly similar to platelet factor 4. The encoded protein displays a strong antiangiogenic function and is regulated by chemokine (C-X-C motif) receptor 3. This protein also impairs tumor growth and can protect against blood-retinal barrier breakdown in diabetes patients. [provided by RefSeq, Nov 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000226524.4 Gencode Gene: ENSG00000109272.4 Transcript (Including UTRs) Position: hg38 chr4:73,853,296-73,854,483 Size: 1,188 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr4:73,853,363-73,854,122 Size: 760 Coding Exon Count: 3
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF00048 - Small cytokines (intecrine/chemokine), interleukin-8 like
ModBase Predicted Comparative 3D Structure on P10720
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.