Human Gene METTL14 (ENST00000388822.10) from GENCODE V44
Description: Homo sapiens methyltransferase like 14 (METTL14), mRNA. (from RefSeq NM_020961)
Gencode Transcript: ENST00000388822.10
Gencode Gene: ENSG00000145388.15
Transcript (Including UTRs)
Position: hg38 chr4:118,685,392-118,715,430 Size: 30,039 Total Exon Count: 11 Strand: +
Coding Region
Position: hg38 chr4:118,685,535-118,710,302 Size: 24,768 Coding Exon Count: 11
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: MET14_HUMAN
DESCRIPTION: RecName: Full=Methyltransferase-like protein 14; EC=2.1.1.-;
FUNCTION: Probable methyltransferase (By similarity).SIMILARITY: Belongs to the MT-A70-like family.SEQUENCE CAUTION: Sequence=BAB13453.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
The following chemicals interact with this gene
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR007757 - MT-A70-like
Pfam Domains: PF05063 - MT-A70
ModBase Predicted Comparative 3D Structure on Q9HCE5
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
LF206328 - JP 2014500723-A/13831: Polycomb-Associated Non-Coding RNAs.MA441905 - JP 2018138019-A/13831: Polycomb-Associated Non-Coding RNAs.AK055555 - Homo sapiens cDNA FLJ30993 fis, clone HLUNG1000064, weakly similar to KARYOGAMY PROTEIN KAR4.AB046847 - Homo sapiens KIAA1627 mRNA for KIAA1627 protein.BC006565 - Homo sapiens methyltransferase like 14, mRNA (cDNA clone MGC:2902 IMAGE:3010654), complete cds.BC007449 - Homo sapiens methyltransferase like 14, mRNA (cDNA clone MGC:4531 IMAGE:3010654), complete cds.LF353258 - JP 2014500723-A/160761: Polycomb-Associated Non-Coding RNAs.MA588835 - JP 2018138019-A/160761: Polycomb-Associated Non-Coding RNAs.AB384254 - Synthetic construct DNA, clone: pF1KSDA1627, Homo sapiens KIAA1627 gene for KIAA1627 protein, complete cds, without stop codon, in Flexi system.CU675451 - Synthetic construct Homo sapiens gateway clone IMAGE:100017311 5' read KIAA1627 mRNA.HQ448248 - Synthetic construct Homo sapiens clone IMAGE:100071649; CCSB004649_03 KIAA1627 protein (KIAA1627) gene, encodes complete protein.KJ894454 - Synthetic construct Homo sapiens clone ccsbBroadEn_03848 METTL14 gene, encodes complete protein.LF353257 - JP 2014500723-A/160760: Polycomb-Associated Non-Coding RNAs.MA588834 - JP 2018138019-A/160760: Polycomb-Associated Non-Coding RNAs.LF353255 - JP 2014500723-A/160758: Polycomb-Associated Non-Coding RNAs.MA588832 - JP 2018138019-A/160758: Polycomb-Associated Non-Coding RNAs.AK296056 - Homo sapiens cDNA FLJ56915 complete cds.LF353254 - JP 2014500723-A/160757: Polycomb-Associated Non-Coding RNAs.MA588831 - JP 2018138019-A/160757: Polycomb-Associated Non-Coding RNAs.LF353252 - JP 2014500723-A/160755: Polycomb-Associated Non-Coding RNAs.MA588829 - JP 2018138019-A/160755: Polycomb-Associated Non-Coding RNAs.LF353251 - JP 2014500723-A/160754: Polycomb-Associated Non-Coding RNAs.MA588828 - JP 2018138019-A/160754: Polycomb-Associated Non-Coding RNAs.LF353250 - JP 2014500723-A/160753: Polycomb-Associated Non-Coding RNAs.MA588827 - JP 2018138019-A/160753: Polycomb-Associated Non-Coding RNAs.JD101799 - Sequence 82823 from Patent EP1572962.JD477733 - Sequence 458757 from Patent EP1572962.LF353249 - JP 2014500723-A/160752: Polycomb-Associated Non-Coding RNAs.MA588826 - JP 2018138019-A/160752: Polycomb-Associated Non-Coding RNAs.JD349348 - Sequence 330372 from Patent EP1572962.JD384369 - Sequence 365393 from Patent EP1572962.JD145166 - Sequence 126190 from Patent EP1572962.JD240966 - Sequence 221990 from Patent EP1572962.JD440952 - Sequence 421976 from Patent EP1572962.JD063471 - Sequence 44495 from Patent EP1572962.JD552294 - Sequence 533318 from Patent EP1572962.JD242619 - Sequence 223643 from Patent EP1572962.JD330762 - Sequence 311786 from Patent EP1572962.JD330763 - Sequence 311787 from Patent EP1572962.JD441161 - Sequence 422185 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: A6NIG1, ENST00000388822.1, ENST00000388822.2, ENST00000388822.3, ENST00000388822.4, ENST00000388822.5, ENST00000388822.6, ENST00000388822.7, ENST00000388822.8, ENST00000388822.9, KIAA1627, MET14_HUMAN, NM_020961, Q969V2, Q9HCE5, uc003icf.1, uc003icf.2, uc003icf.3, uc003icf.4, uc003icf.5UCSC ID: ENST00000388822.10RefSeq Accession: NM_020961
Protein: Q9HCE5
(aka MET14_HUMAN)
CCDS: CCDS34053.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.