Human Gene HSPA4L (ENST00000296464.9) from GENCODE V44
Description: Homo sapiens heat shock protein family A (Hsp70) member 4 like (HSPA4L), transcript variant 1, mRNA. (from RefSeq NM_014278) RefSeq Summary (NM_014278): The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]. Gencode Transcript: ENST00000296464.9 Gencode Gene: ENSG00000164070.12 Transcript (Including UTRs) Position: hg38 chr4:127,782,322-127,840,733 Size: 58,412 Total Exon Count: 19 Strand: + Coding Region Position: hg38 chr4:127,782,551-127,832,874 Size: 50,324 Coding Exon Count: 19
ID:HS74L_HUMAN DESCRIPTION: RecName: Full=Heat shock 70 kDa protein 4L; AltName: Full=Heat shock 70-related protein APG-1; AltName: Full=Osmotic stress protein 94; FUNCTION: Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase (By similarity). SUBUNIT: Homodimer (By similarity). SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Note=May translocate to the nucleus after heat shock (By similarity). INDUCTION: By heat shock and osmotic imbalance. PTM: Phosphorylated upon DNA damage, probably by ATM or ATR. SIMILARITY: Belongs to the heat shock protein 70 family.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O95757
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
AK303053 - Homo sapiens cDNA FLJ55529 complete cds, highly similar to Heat shock 70 kDa protein 4L. BC040560 - Homo sapiens heat shock 70kDa protein 4-like, mRNA (cDNA clone MGC:41835 IMAGE:5270824), complete cds. HM005687 - Homo sapiens clone HTL-T-64n testis tissue sperm-binding protein Li 64n mRNA, complete cds. AK027822 - Homo sapiens cDNA FLJ14916 fis, clone PLACE1006958, highly similar to Heat shock 70 kDa protein 4L. AK307464 - Homo sapiens cDNA, FLJ97412. AY290862 - Homo sapiens heat shock protein apg-1 mRNA, complete cds. AB023421 - Homo sapiens mRNA for heat shock protein apg-1, complete cds. EF197155 - Homo sapiens heat shock 70 kDa protein 4-like protein mRNA, complete cds. KJ893295 - Synthetic construct Homo sapiens clone ccsbBroadEn_02689 HSPA4L gene, encodes complete protein. AK302115 - Homo sapiens cDNA FLJ59635 complete cds, highly similar to Heat shock 70 kDa protein 4L. JD214234 - Sequence 195258 from Patent EP1572962. JD202835 - Sequence 183859 from Patent EP1572962. JD434703 - Sequence 415727 from Patent EP1572962. JD439468 - Sequence 420492 from Patent EP1572962. JD225548 - Sequence 206572 from Patent EP1572962. JD133155 - Sequence 114179 from Patent EP1572962. JD083521 - Sequence 64545 from Patent EP1572962. JD357386 - Sequence 338410 from Patent EP1572962. JD481533 - Sequence 462557 from Patent EP1572962. JD063166 - Sequence 44190 from Patent EP1572962. JD366345 - Sequence 347369 from Patent EP1572962. JD451177 - Sequence 432201 from Patent EP1572962. JD098762 - Sequence 79786 from Patent EP1572962. JD375590 - Sequence 356614 from Patent EP1572962. JD340668 - Sequence 321692 from Patent EP1572962. JD499632 - Sequence 480656 from Patent EP1572962. JD286626 - Sequence 267650 from Patent EP1572962. JD511473 - Sequence 492497 from Patent EP1572962. JD522285 - Sequence 503309 from Patent EP1572962. JD229714 - Sequence 210738 from Patent EP1572962. JD454062 - Sequence 435086 from Patent EP1572962. JD375939 - Sequence 356963 from Patent EP1572962. JD098804 - Sequence 79828 from Patent EP1572962. BC042959 - Homo sapiens cDNA clone IMAGE:5285801. JD308188 - Sequence 289212 from Patent EP1572962. JD360663 - Sequence 341687 from Patent EP1572962. AK090904 - Homo sapiens cDNA FLJ33585 fis, clone BRAMY2012163. JD243281 - Sequence 224305 from Patent EP1572962.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein O95757 (Reactome details) participates in the following event(s):
R-HSA-5251942 Hikeshi binds HSP70s:ATP R-HSA-5251959 HSP40s activate intrinsic ATPase activity of HSP70s in the cytosol R-HSA-5252079 HSP110s exchange ATP for ADP on HSP70s:ADP R-HSA-5251955 HSP40s activate intrinsic ATPase activity of HSP70s in the nucleoplasm R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm R-HSA-3371453 Regulation of HSF1-mediated heat shock response R-HSA-3371556 Cellular response to heat stress R-HSA-2262752 Cellular responses to stress R-HSA-8953897 Cellular responses to external stimuli
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