Human Gene RXFP1 (ENST00000307765.10) from GENCODE V44
Description: Homo sapiens relaxin family peptide receptor 1 (RXFP1), transcript variant 12, non-coding RNA. (from RefSeq NR_045583) RefSeq Summary (NM_021634): This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane receptor superfamily. The encoded protein plays a critical role in sperm motility, pregnancy and parturition as a receptor for the protein hormone relaxin. Decreased expression of this gene may play a role in endometriosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]. Gencode Transcript: ENST00000307765.10 Gencode Gene: ENSG00000171509.16 Transcript (Including UTRs) Position: hg38 chr4:158,521,882-158,653,372 Size: 131,491 Total Exon Count: 18 Strand: + Coding Region Position: hg38 chr4:158,521,977-158,652,055 Size: 130,079 Coding Exon Count: 18
ID:RXFP1_HUMAN DESCRIPTION: RecName: Full=Relaxin receptor 1; AltName: Full=Leucine-rich repeat-containing G-protein coupled receptor 7; AltName: Full=Relaxin family peptide receptor 1; FUNCTION: Receptor for relaxins. The activity of this receptor is mediated by G proteins leading to stimulation of adenylate cyclase and an increase of cAMP. Binding of the ligand may also activate a tyrosine kinase pathway that inhibits the activity of a phosphodiesterase that degrades cAMP. SUBCELLULAR LOCATION: Cell membrane; Multi-pass membrane protein. TISSUE SPECIFICITY: Expressed in the brain, kidney, testis, placenta, uterus, ovary, adrenal, prostate, skin and heart. Not detected in spleen. SIMILARITY: Belongs to the G-protein coupled receptor 1 family. SIMILARITY: Contains 1 LDL-receptor class A domain. SIMILARITY: Contains 9 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 LRRNT domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9HBX9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0004871 signal transducer activity GO:0004930 G-protein coupled receptor activity GO:0005515 protein binding GO:0046872 metal ion binding
US Server
