Human Gene TENM3 (ENST00000511685.6) from GENCODE V44
Description: Homo sapiens teneurin transmembrane protein 3 (TENM3), mRNA. (from RefSeq NM_001080477) RefSeq Summary (NM_001080477): This gene encodes a large transmembrane protein that may be involved in the regulation of neuronal development. Mutation in this gene causes microphthalmia. [provided by RefSeq, Aug 2015]. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. Gencode Transcript: ENST00000511685.6 Gencode Gene: ENSG00000218336.9 Transcript (Including UTRs) Position: hg38 chr4:182,243,402-182,803,024 Size: 559,623 Total Exon Count: 28 Strand: + Coding Region Position: hg38 chr4:182,324,021-182,800,351 Size: 476,331 Coding Exon Count: 27
ID:TEN3_HUMAN DESCRIPTION: RecName: Full=Teneurin-3; Short=Ten-3; AltName: Full=Protein Odd Oz/ten-m homolog 3; AltName: Full=Tenascin-M3; Short=Ten-m3; AltName: Full=Teneurin transmembrane protein 3; FUNCTION: May function as a cellular signal transducer. SUBUNIT: Homodimer; disulfide-linked (Probable). SUBCELLULAR LOCATION: Membrane; Single-pass type II membrane protein (Probable). TISSUE SPECIFICITY: Expressed in adult and fetal brain, slightly lower levels in testis and ovary, and intermediate levels in all other peripheral tissues examined. Not expressed in spleen or liver. Expression was high in brain, with highest levels in amygdala and caudate nucleus, followed by thalamus and subthalamic nucleus. DOMAIN: EGF-like domains 2 and 5 which have an odd number of cysteines might enable the formation of intermolecular disulfide bonds. DOMAIN: Cytoplasmic proline-rich regions could serve as docking domains for intracellular SH3-containing proteins. SIMILARITY: Belongs to the tenascin family. Teneurin subfamily. SIMILARITY: Contains 8 EGF-like domains. SIMILARITY: Contains 5 NHL repeats. SIMILARITY: Contains 1 teneurin N-terminal domain. SIMILARITY: Contains 23 YD repeats. SEQUENCE CAUTION: Sequence=BAA91633.1; Type=Erroneous initiation; Sequence=BAA91879.1; Type=Erroneous initiation; Sequence=BAB55138.1; Type=Erroneous initiation;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF06484 - Teneurin Intracellular Region
ModBase Predicted Comparative 3D Structure on Q9P273
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
