Human Gene NUP155 (ENST00000231498.8) from GENCODE V44
  Description: Homo sapiens nucleoporin 155 (NUP155), transcript variant 1, mRNA. (from RefSeq NM_153485)
RefSeq Summary (NM_153485): Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013].
Gencode Transcript: ENST00000231498.8
Gencode Gene: ENSG00000113569.16
Transcript (Including UTRs)
   Position: hg38 chr5:37,288,137-37,371,106 Size: 82,970 Total Exon Count: 35 Strand: -
Coding Region
   Position: hg38 chr5:37,291,900-37,370,977 Size: 79,078 Coding Exon Count: 35 

Page IndexSequence and LinksUniProtKB CommentsPrimersMalaCardsCTD
RNA-Seq ExpressionMicroarray ExpressionRNA StructureProtein StructureOther SpeciesGO Annotations
mRNA DescriptionsPathwaysOther NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:37,288,137-37,371,106)mRNA (may differ from genome)Protein (1391 aa)
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-  Comments and Description Text from UniProtKB
  ID: NU155_HUMAN
DESCRIPTION: RecName: Full=Nuclear pore complex protein Nup155; AltName: Full=155 kDa nucleoporin; AltName: Full=Nucleoporin Nup155;
FUNCTION: Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport (By similarity).
SUBUNIT: Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B.
SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis (By similarity).
TISSUE SPECIFICITY: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas.
PTM: Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity).
SIMILARITY: Belongs to the non-repetitive/WGA-negative nucleoporin family.
SEQUENCE CAUTION: Sequence=AAD52966.1; Type=Erroneous gene model prediction; Sequence=BAA34511.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;

-  Primer design for this transcript
 

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Click here to load the transcript sequence and exon structure into Primer3Plus

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Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  MalaCards Disease Associations
  MalaCards Gene Search: NUP155
Diseases sorted by gene-association score: atrial fibrillation 15* (1250), familial atrial fibrillation* (85), atrial fibrillation (24)
* = Manually curated disease association

-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 25.24 RPKM in Testis
Total median expression: 148.20 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -42.30129-0.328 Picture PostScript Text
3' UTR -1265.303763-0.336 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR007187 - Nucleoporin_Nup133/Nup155_C
IPR014908 - Nucleoporin_Nup133/Nup155_N
IPR004870 - Nucleoporin_Nup155

Pfam Domains:
PF03177 - Non-repetitive/WGA-negative nucleoporin C-terminal
PF08801 - Nup133 N terminal like

ModBase Predicted Comparative 3D Structure on O75694
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-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserGenome BrowserGenome BrowserGenome BrowserNo ortholog
Gene Details     
Gene Sorter     
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Protein SequenceProtein SequenceProtein SequenceProtein SequenceProtein Sequence 
AlignmentAlignmentAlignmentAlignmentAlignment 

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0017056 structural constituent of nuclear pore

Biological Process:
GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery
GO:0006405 RNA export from nucleus
GO:0006406 mRNA export from nucleus
GO:0006606 protein import into nucleus
GO:0006913 nucleocytoplasmic transport
GO:0006998 nuclear envelope organization
GO:0015031 protein transport
GO:0016032 viral process
GO:0036228 protein targeting to nuclear inner membrane
GO:0051028 mRNA transport
GO:0086014 atrial cardiac muscle cell action potential

Cellular Component:
GO:0005634 nucleus
GO:0005635 nuclear envelope
GO:0005643 nuclear pore
GO:0016020 membrane
GO:0031965 nuclear membrane
GO:0044611 nuclear pore inner ring


-  Descriptions from all associated GenBank mRNAs
  AB018334 - Homo sapiens KIAA0791 mRNA for KIAA0791 protein.
LF385027 - JP 2014500723-A/192530: Polycomb-Associated Non-Coding RNAs.
MA620604 - JP 2018138019-A/192530: Polycomb-Associated Non-Coding RNAs.
AK297143 - Homo sapiens cDNA FLJ56637 complete cds, highly similar to Nuclear pore complex protein Nup155.
BC039257 - Homo sapiens nucleoporin 155kDa, mRNA (cDNA clone MGC:33787 IMAGE:5295664), complete cds.
AJ007558 - Homo sapiens mRNA for nucleoporin 155.
AK315028 - Homo sapiens cDNA, FLJ95970.
KJ898060 - Synthetic construct Homo sapiens clone ccsbBroadEn_07454 NUP155 gene, encodes complete protein.
AB385384 - Synthetic construct DNA, clone: pF1KA0791, Homo sapiens NUP155 gene for nucleoporin 155kDa, complete cds, without stop codon, in Flexi system.
CU691696 - Synthetic construct Homo sapiens gateway clone IMAGE:100020552 5' read NUP155 mRNA.
JD414691 - Sequence 395715 from Patent EP1572962.
JD397005 - Sequence 378029 from Patent EP1572962.
JD476663 - Sequence 457687 from Patent EP1572962.
JD560656 - Sequence 541680 from Patent EP1572962.
JD414690 - Sequence 395714 from Patent EP1572962.
JD432395 - Sequence 413419 from Patent EP1572962.
JD420950 - Sequence 401974 from Patent EP1572962.
JD379800 - Sequence 360824 from Patent EP1572962.
JD415041 - Sequence 396065 from Patent EP1572962.
JD507409 - Sequence 488433 from Patent EP1572962.
JD374881 - Sequence 355905 from Patent EP1572962.
JD515657 - Sequence 496681 from Patent EP1572962.
JD374880 - Sequence 355904 from Patent EP1572962.
JD384889 - Sequence 365913 from Patent EP1572962.
JD242928 - Sequence 223952 from Patent EP1572962.
JD552373 - Sequence 533397 from Patent EP1572962.
JD028935 - Sequence 9959 from Patent EP1572962.
JD452572 - Sequence 433596 from Patent EP1572962.
JD558228 - Sequence 539252 from Patent EP1572962.
JD558229 - Sequence 539253 from Patent EP1572962.
JD564281 - Sequence 545305 from Patent EP1572962.
LF335972 - JP 2014500723-A/143475: Polycomb-Associated Non-Coding RNAs.
MA571549 - JP 2018138019-A/143475: Polycomb-Associated Non-Coding RNAs.
AL117585 - Homo sapiens mRNA; cDNA DKFZp434L038 (from clone DKFZp434L038).
AK002103 - Homo sapiens cDNA FLJ11241 fis, clone PLACE1008603, highly similar to Nuclear pore complex protein Nup155.
LF335971 - JP 2014500723-A/143474: Polycomb-Associated Non-Coding RNAs.
MA571548 - JP 2018138019-A/143474: Polycomb-Associated Non-Coding RNAs.
LF335968 - JP 2014500723-A/143471: Polycomb-Associated Non-Coding RNAs.
MA571545 - JP 2018138019-A/143471: Polycomb-Associated Non-Coding RNAs.
LF335964 - JP 2014500723-A/143467: Polycomb-Associated Non-Coding RNAs.
MA571541 - JP 2018138019-A/143467: Polycomb-Associated Non-Coding RNAs.
LF335963 - JP 2014500723-A/143466: Polycomb-Associated Non-Coding RNAs.
MA571540 - JP 2018138019-A/143466: Polycomb-Associated Non-Coding RNAs.
LF335962 - JP 2014500723-A/143465: Polycomb-Associated Non-Coding RNAs.
MA571539 - JP 2018138019-A/143465: Polycomb-Associated Non-Coding RNAs.
LF335961 - JP 2014500723-A/143464: Polycomb-Associated Non-Coding RNAs.
MA571538 - JP 2018138019-A/143464: Polycomb-Associated Non-Coding RNAs.
LF335960 - JP 2014500723-A/143463: Polycomb-Associated Non-Coding RNAs.
MA571537 - JP 2018138019-A/143463: Polycomb-Associated Non-Coding RNAs.
LF335959 - JP 2014500723-A/143462: Polycomb-Associated Non-Coding RNAs.
MA571536 - JP 2018138019-A/143462: Polycomb-Associated Non-Coding RNAs.
LF335958 - JP 2014500723-A/143461: Polycomb-Associated Non-Coding RNAs.
MA571535 - JP 2018138019-A/143461: Polycomb-Associated Non-Coding RNAs.
JD181861 - Sequence 162885 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  Reactome (by CSHL, EBI, and GO)

Protein O75694 (Reactome details) participates in the following event(s):

R-HSA-75096 Docking of the TAP:EJC Complex with the NPC
R-HSA-165043 Rev multimer-bound HIV mRNA:Crm1:Ran:GTP complex associates with the NPC
R-HSA-180622 Vpr binds nucleoporins
R-HSA-180710 Rev:importin beta:B23 recruited to the nuclear pore
R-HSA-2990882 CDK1 phosphorylates NUP98
R-HSA-75098 mRNP complex dissociates from cytosolic face of NPC
R-HSA-165047 Translocation of nuclear RNA transport complex to cytoplasm
R-HSA-180732 Translocation of Rev:importin-beta:B23 to the nucleus
R-HSA-2990880 NEK6/NEK7 phosphorylates NUP98
R-HSA-170796 NPC transports GCK1:GKRP from cytosol to nucleoplasm
R-HSA-5578744 Importin-8 imports AGO2:miRNA into the nucleus
R-HSA-6783483 tRNA:XPOT:RAN:GTP translocates from the nucleus to the cytosol
R-HSA-3000348 RANBP2 SUMOylates SP100 with SUMO2
R-HSA-3000399 RANBP2 SUMOylates SP100 with SUMO1
R-HSA-3000411 RANBP2 SUMOylates PML with SUMO2
R-HSA-4570493 RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1
R-HSA-4615872 RANBP2 SUMOylates HDAC4 with SUMO1
R-HSA-4615987 RANBP2 SUMOylates HDAC4 with SUMO2,3
R-HSA-5228508 RANBP2 SUMOylates PML with SUMO1
R-HSA-5228525 RANBP2 SUMOylates TOP2A with SUMO1
R-HSA-192627 Viral mRNA Export
R-HSA-192925 Export of Spliced Viral mRNA
R-HSA-5252041 NPC transports Hikeshi:HSP70s:ATP from cytosol to nucleoplasm
R-HSA-159236 Transport of Mature mRNA derived from an Intron-Containing Transcript
R-HSA-165054 Rev-mediated nuclear export of HIV RNA
R-HSA-180910 Vpr-mediated nuclear import of PICs
R-HSA-180746 Nuclear import of Rev protein
R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
R-HSA-72202 Transport of Mature Transcript to Cytoplasm
R-HSA-162599 Late Phase of HIV Life Cycle
R-HSA-177243 Interactions of Rev with host cellular proteins
R-HSA-176033 Interactions of Vpr with host cellular proteins
R-HSA-2980766 Nuclear Envelope Breakdown
R-HSA-170822 Regulation of Glucokinase by Glucokinase Regulatory Protein
R-HSA-168276 NS1 Mediated Effects on Host Pathways
R-HSA-1169408 ISG15 antiviral mechanism
R-HSA-5578749 Transcriptional regulation by small RNAs
R-HSA-6784531 tRNA processing in the nucleus
R-HSA-3108214 SUMOylation of DNA damage response and repair proteins
R-HSA-4570464 SUMOylation of RNA binding proteins
R-HSA-4551638 SUMOylation of chromatin organization proteins
R-HSA-4615885 SUMOylation of DNA replication proteins
R-HSA-168325 Viral Messenger RNA Synthesis
R-HSA-3371453 Regulation of HSF1-mediated heat shock response
R-HSA-72203 Processing of Capped Intron-Containing Pre-mRNA
R-HSA-162587 HIV Life Cycle
R-HSA-162909 Host Interactions of HIV factors
R-HSA-68875 Mitotic Prophase
R-HSA-70171 Glycolysis
R-HSA-168253 Host Interactions with Influenza Factors
R-HSA-1169410 Antiviral mechanism by IFN-stimulated genes
R-HSA-211000 Gene Silencing by RNA
R-HSA-72306 tRNA processing
R-HSA-3108232 SUMO E3 ligases SUMOylate target proteins
R-HSA-168273 Influenza Viral RNA Transcription and Replication
R-HSA-3371556 Cellular response to heat stress
R-HSA-8953854 Metabolism of RNA
R-HSA-162906 HIV Infection
R-HSA-68886 M Phase
R-HSA-70326 Glucose metabolism
R-HSA-168254 Influenza Infection
R-HSA-913531 Interferon Signaling
R-HSA-74160 Gene expression (Transcription)
R-HSA-2990846 SUMOylation
R-HSA-168255 Influenza Life Cycle
R-HSA-2262752 Cellular responses to stress
R-HSA-5663205 Infectious disease
R-HSA-69278 Cell Cycle (Mitotic)
R-HSA-71387 Metabolism of carbohydrates
R-HSA-1280215 Cytokine Signaling in Immune system
R-HSA-597592 Post-translational protein modification
R-HSA-8953897 Cellular responses to external stimuli
R-HSA-1643685 Disease
R-HSA-1640170 Cell Cycle
R-HSA-1430728 Metabolism
R-HSA-168256 Immune System
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000231498.1, ENST00000231498.2, ENST00000231498.3, ENST00000231498.4, ENST00000231498.5, ENST00000231498.6, ENST00000231498.7, KIAA0791, NM_153485, NU155_HUMAN, O75694, Q9UBE9, Q9UFL5, uc003jku.1, uc003jku.2, uc003jku.3, uc003jku.4
UCSC ID: ENST00000231498.8
RefSeq Accession: NM_153485
Protein: O75694 (aka NU155_HUMAN or N155_HUMAN)
CCDS: CCDS3921.1, CCDS43310.1, CCDS64142.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.