Human Gene NUP155 (ENST00000231498.8) from GENCODE V44
Description: Homo sapiens nucleoporin 155 (NUP155), transcript variant 1, mRNA. (from RefSeq NM_153485) RefSeq Summary (NM_153485): Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of atrial fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000231498.8 Gencode Gene: ENSG00000113569.16 Transcript (Including UTRs) Position: hg38 chr5:37,288,137-37,371,106 Size: 82,970 Total Exon Count: 35 Strand: - Coding Region Position: hg38 chr5:37,291,900-37,370,977 Size: 79,078 Coding Exon Count: 35
ID:NU155_HUMAN DESCRIPTION: RecName: Full=Nuclear pore complex protein Nup155; AltName: Full=155 kDa nucleoporin; AltName: Full=Nucleoporin Nup155; FUNCTION: Essential component of nuclear pore complex. Nucleoporins may be involved both in binding and translocating proteins during nucleocytoplasmic transport (By similarity). SUBUNIT: Interacts with GLE1. Able to form a heterotrimer with GLE1 and NUPL2 in vitro. Forms a complex with NUP53, NUP93, NUP205 and lamin B. SUBCELLULAR LOCATION: Nucleus, nuclear pore complex (By similarity). Nucleus membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Nucleus membrane; Peripheral membrane protein; Nucleoplasmic side (By similarity). Note=In mitosis, assumes a diffuse cytoplasmic distribution probably as a monomer, before reversing back into a punctate nuclear surface localization at the end of mitosis (By similarity). TISSUE SPECIFICITY: Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. PTM: Phosphorylated. Phosphorylation and dephosphorylation may be important for the function of NUP155 and may play a role in the reversible disassembly of the nuclear pore complex during mitosis (By similarity). SIMILARITY: Belongs to the non-repetitive/WGA-negative nucleoporin family. SEQUENCE CAUTION: Sequence=AAD52966.1; Type=Erroneous gene model prediction; Sequence=BAA34511.2; Type=Erroneous initiation; Note=Translation N-terminally shortened;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF03177 - Non-repetitive/WGA-negative nucleoporin C-terminal PF08801 - Nup133 N terminal like
ModBase Predicted Comparative 3D Structure on O75694
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Molecular Function: GO:0005215 transporter activity GO:0005515 protein binding GO:0017056 structural constituent of nuclear pore
Biological Process: GO:0000972 transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery GO:0006405 RNA export from nucleus GO:0006406 mRNA export from nucleus GO:0006606 protein import into nucleus GO:0006913 nucleocytoplasmic transport GO:0006998 nuclear envelope organization GO:0015031 protein transport GO:0016032 viral process GO:0036228 protein targeting to nuclear inner membrane GO:0051028 mRNA transport GO:0086014 atrial cardiac muscle cell action potential