Human Gene FYB1 (ENST00000351578.12) from GENCODE V44
Description: Homo sapiens FYN binding protein 1 (FYB1), transcript variant 2, mRNA. (from RefSeq NM_199335) RefSeq Summary (NM_199335): The protein encoded by this gene is an adapter for the FYN protein and LCP2 signaling cascades in T-cells. The encoded protein is involved in platelet activation and controls the expression of interleukin-2. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2011]. Gencode Transcript: ENST00000351578.12 Gencode Gene: ENSG00000082074.19 Transcript (Including UTRs) Position: hg38 chr5:39,105,252-39,219,563 Size: 114,312 Total Exon Count: 18 Strand: - Coding Region Position: hg38 chr5:39,107,443-39,202,960 Size: 95,518 Coding Exon Count: 17
ID:FYB_HUMAN DESCRIPTION: RecName: Full=FYN-binding protein; AltName: Full=Adhesion and degranulation promoting adaptor protein; Short=ADAP; AltName: Full=FYB-120/130; Short=p120/p130; AltName: Full=FYN-T-binding protein; AltName: Full=SLAP-130; AltName: Full=SLP-76-associated phosphoprotein; FUNCTION: Acts as an adapter protein of the FYN and LCP2 signaling cascades in T-cells. Modulates the expression of interleukin-2 (IL-2). Involved in platelet activation. Prevents the degradation of SKAP1 and SKAP2. May play a role in linking T-cell signaling to remodeling of the actin cytoskeleton. SUBUNIT: Part of a complex consisting of SKAP2, FYB and PTPNS1. Part of a complex consisting of SKAP2, FYB and LILRB3 (By similarity). Interacts with FYN, LCP2, SKAP1 and SKAP2. Interacts with FASLG. Interacts with EVL. INTERACTION: P16333:NCK1; NbExp=3; IntAct=EBI-1753267, EBI-389883; Q86WV1:SKAP1; NbExp=2; IntAct=EBI-1753267, EBI-2477305; SUBCELLULAR LOCATION: Cytoplasm. Nucleus (By similarity). TISSUE SPECIFICITY: Expressed in hematopoietic tissues such as myeloid and T-cells, spleen and thymus. Not expressed in B-cells, nor in non-lymphoid tissues. PTM: T-cell receptor ligation leads to increased tyrosine phosphorylation. SIMILARITY: Contains 1 SH3 domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on O15117
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006468 protein phosphorylation GO:0006607 NLS-bearing protein import into nucleus GO:0006955 immune response GO:0007165 signal transduction GO:0008150 biological_process GO:0035556 intracellular signal transduction GO:0050852 T cell receptor signaling pathway GO:0072659 protein localization to plasma membrane