Human Gene SRP19 (ENST00000282999.7) from GENCODE V44
  Description: Homo sapiens signal recognition particle 19 (SRP19), transcript variant 2, mRNA. (from RefSeq NM_001204193)
Gencode Transcript: ENST00000282999.7
Gencode Gene: ENSG00000153037.15
Transcript (Including UTRs)
   Position: hg38 chr5:112,861,305-112,867,935 Size: 6,631 Total Exon Count: 5 Strand: +
Coding Region
   Position: hg38 chr5:112,861,377-112,867,403 Size: 6,027 Coding Exon Count: 5 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDMicroarray Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsPathways
Other NamesMethods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr5:112,861,305-112,867,935)mRNA (may differ from genome)Protein (110 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCHPRDLynxMalacardsMGIneXtProt
OMIMPubMedReactomeUniProtKBBioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: SRP19_HUMAN
DESCRIPTION: RecName: Full=Signal recognition particle 19 kDa protein; Short=SRP19;
FUNCTION: Signal-recognition-particle assembly, binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.
SUBUNIT: Signal recognition particle consists of a 7S RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.
SUBCELLULAR LOCATION: Cytoplasm.
SIMILARITY: Belongs to the SRP19 family.
WEB RESOURCE: Name=Wikipedia; Note=Signal recognition particle entry; URL="http://en.wikipedia.org/wiki/Signal-recognition_particle";

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene           more ... click here to view the complete list

+  Microarray Expression Data
  Press "+" in the title bar above to open this section.

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -26.3072-0.365 Picture PostScript Text
3' UTR -105.00532-0.197 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR002778 - Signal_recog_particle_SRP19

Pfam Domains:
PF01922 - SRP19 protein

Protein Data Bank (PDB) 3-D Structure
MuPIT help
1JID - X-ray MuPIT 1MFQ - X-ray MuPIT 1RY1 - EM MuPIT 2J37 - EM 3KTV - X-ray MuPIT


ModBase Predicted Comparative 3D Structure on P09132
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The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
Genome BrowserGenome BrowserNo orthologNo orthologNo orthologNo ortholog
Gene Details     
Gene Sorter     
MGIRGD    
Protein SequenceProtein Sequence    
AlignmentAlignment    

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0008312 7S RNA binding
GO:0043022 ribosome binding

Biological Process:
GO:0006613 cotranslational protein targeting to membrane
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006616 SRP-dependent cotranslational protein targeting to membrane, translocation
GO:0006617 SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition
GO:0042493 response to drug

Cellular Component:
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005786 signal recognition particle, endoplasmic reticulum targeting
GO:0005829 cytosol
GO:0048500 signal recognition particle


-  Descriptions from all associated GenBank mRNAs
  AK311803 - Homo sapiens cDNA, FLJ92064, Homo sapiens signal recognition particle 19kDa (SRP19), mRNA.
BC000186 - Homo sapiens, Similar to signal recognition particle 19kD, clone IMAGE:3352633, mRNA.
X12791 - Human mRNA for 19kD protein of signal recognition particle (SRP).
BC017830 - Homo sapiens signal recognition particle 19kDa, mRNA (cDNA clone MGC:22478 IMAGE:4252554), complete cds.
AK313576 - Homo sapiens cDNA, FLJ94140, highly similar to Homo sapiens U2(RNU2) small nuclear RNA auxillary factor 1-like 1(U2AF1L1), mRNA.
BC010947 - Homo sapiens signal recognition particle 19kDa, mRNA (cDNA clone MGC:13596 IMAGE:4285753), complete cds.
JD422459 - Sequence 403483 from Patent EP1572962.
JD409361 - Sequence 390385 from Patent EP1572962.
BC018669 - Homo sapiens cDNA clone IMAGE:4249893, containing frame-shift errors.
AB587423 - Synthetic construct DNA, clone: pF1KB6746, Homo sapiens SRP19 gene for signal recognition particle 19kDa, without stop codon, in Flexi system.
JD202486 - Sequence 183510 from Patent EP1572962.

-  Biochemical and Signaling Pathways
  KEGG - Kyoto Encyclopedia of Genes and Genomes
hsa03060 - Protein export

Reactome (by CSHL, EBI, and GO)

Protein P09132 (Reactome details) participates in the following event(s):

R-HSA-1799332 Nascent polypeptide:mRNA:ribosome complex binds signal recognition particle (SRP)
R-HSA-1799326 Signal-containing nascent peptide translocates to endoplasmic reticulum
R-HSA-1799330 The SRP receptor binds the SRP:nascent peptide:ribosome complex
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-72766 Translation
R-HSA-392499 Metabolism of proteins

-  Other Names for This Gene
  Alternate Gene Symbols: B2R4E9, D6RCQ5, ENST00000282999.1, ENST00000282999.2, ENST00000282999.3, ENST00000282999.4, ENST00000282999.5, ENST00000282999.6, NM_001204193, P09132, Q05D77, Q96FG6, SRP19_HUMAN, uc003kqb.1, uc003kqb.2, uc003kqb.3
UCSC ID: ENST00000282999.7
RefSeq Accession: NM_001204193
Protein: P09132 (aka SRP19_HUMAN or SR19_HUMAN)
CCDS: CCDS56375.1

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.