ID:PERP1_HUMAN DESCRIPTION: RecName: Full=Plasma cell-induced resident endoplasmic reticulum protein; Short=Plasma cell-induced resident ER protein; Short=pERp1; AltName: Full=Proapoptotic caspase adapter protein; Flags: Precursor; FUNCTION: Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. SUBUNIT: Part of the ER chaperone complex, a multi-protein complex in the endoplasmic reticulum containing a large number of molecular chaperones which associates with unassembled incompletely folded immunoglobulin heavy chains (By similarity). Isoform 2 interacts with CASP2 and CASP9. SUBCELLULAR LOCATION: Isoform 1: Endoplasmic reticulum (By similarity). SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. Note=Diffuse granular localization in the cytoplasm surrounding the nucleus. TISSUE SPECIFICITY: Widely expressed with highest levels in adult brain, small intestine and lymphoid tissues such as thymus and spleen. Expression is frequently lower in intestinal-type gastric cancer. INDUCTION: Down-regulated in primary B-cells early after ligand- stimulated activation. PTM: Forms an interchain disulfide bond with IgM monomers (By similarity). SIMILARITY: Belongs to the PERP1 family. SEQUENCE CAUTION: Sequence=AAF36110.1; Type=Erroneous translation; Note=Wrong choice of frame;
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF11938 - TLR4 regulator and MIR-interacting MSAP
ModBase Predicted Comparative 3D Structure on Q8WU39
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0002642 positive regulation of immunoglobulin biosynthetic process GO:0006915 apoptotic process GO:0008284 positive regulation of cell proliferation GO:0030888 regulation of B cell proliferation GO:0033622 integrin activation GO:0042127 regulation of cell proliferation GO:2001274 negative regulation of glucose import in response to insulin stimulus
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