Human Gene NR3C1 (ENST00000231509.7) from GENCODE V44
Description: Homo sapiens nuclear receptor subfamily 3 group C member 1 (NR3C1), transcript variant 14, mRNA. (from RefSeq NM_001364185) RefSeq Summary (NM_001024094): This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011]. Gencode Transcript: ENST00000231509.7 Gencode Gene: ENSG00000113580.15 Transcript (Including UTRs) Position: hg38 chr5:143,281,162-143,403,689 Size: 122,528 Total Exon Count: 9 Strand: - Coding Region Position: hg38 chr5:143,281,889-143,400,839 Size: 118,951 Coding Exon Count: 8
ID:GCR_HUMAN DESCRIPTION: RecName: Full=Glucocorticoid receptor; Short=GR; AltName: Full=Nuclear receptor subfamily 3 group C member 1; FUNCTION: Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation (By similarity). SUBUNIT: Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1. INTERACTION: P59598:Asxl1 (xeno); NbExp=2; IntAct=EBI-493507, EBI-5743705; Q6ZU52:KIAA0408; NbExp=2; IntAct=EBI-493507, EBI-739493; Q62667:Mvp (xeno); NbExp=2; IntAct=EBI-493507, EBI-918333; P82094:TMF1; NbExp=3; IntAct=EBI-493507, EBI-949763; SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Cytoplasmic in the absence of ligand, nuclear after ligand-binding. SUBCELLULAR LOCATION: Isoform Beta: Nucleus. Note=Localized largely in the nucleus. TISSUE SPECIFICITY: Widely expressed. In the heart, detected in left and right atria, left and right ventricles, aorta, apex, intraventricular septum, and atrioventricular node as well as whole adult and fetal heart. DOMAIN: Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. PTM: Increased proteasome-mediated degradation in response to glucocorticoids. PTM: Phosphorylated in the absence of hormone; becomes hyperphosphorylated in the presence of glucocorticoid. The Ser- 203-phosphorylated form is mainly cytoplasmic, and the Ser-211- phosphorylated form is nuclear. Transcriptional activity correlates with the amount of phosphorylation at Ser-211. PTM: Sumoylated; this reduces transcription transactivation. PTM: Ubiquitinated; restricts glucocorticoid-mediated transcriptional signaling (By similarity). POLYMORPHISM: Carriers of the 22-Glu-Lys-23 allele are relatively more resistant to the effects of GCs with respect to the sensitivity of the adrenal feedback mechanism than non-carriers, resulting in a better metabolic health profile. Carriers have a better survival than non-carriers, as well as lower serum CRP levels. The 22-Glu-Lys-23 polymorphism is associated with a sex- specific, beneficial body composition at young-adult age, as well as greater muscle strength in males. DISEASE: Defects in NR3C1 are a cause of glucocorticoid resistance (GCRES) [MIM:138040]; also known as cortisol resistance. It is a hypertensive, hyperandrogenic disorder characterized by increased serum cortisol concentrations. Inheritance is autosomal dominant. MISCELLANEOUS: High constitutive expression of isoform beta by neutrophils may provide a mechanism by which these cells escape glucocorticoid-induced cell death. Up-regulation by proinflammatory cytokines such as IL8 further enhances their survival in the presence of glucocorticoids during inflammation. MISCELLANEOUS: Can up- or down-modulate aggregation and nuclear localization of expanded polyglutamine polypeptides derived from AR and HD through specific regulation of gene expression. Aggregation and nuclear localization of expanded polyglutamine proteins are regulated cellular processes that can be modulated by this receptor, a well-characterized transcriptional regulator. SIMILARITY: Belongs to the nuclear hormone receptor family. NR3 subfamily. SIMILARITY: Contains 1 nuclear receptor DNA-binding domain. WEB RESOURCE: Name=GeneReviews; URL="http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/NR3C1"; WEB RESOURCE: Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/nr3c1/"; WEB RESOURCE: Name=Wikipedia; Note=Glucocorticoid receptor entry; URL="http://en.wikipedia.org/wiki/Glucocorticoid_receptor";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P04150
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
KJ891299 - Synthetic construct Homo sapiens clone ccsbBroadEn_00693 NR3C1 gene, encodes complete protein. KR710513 - Synthetic construct Homo sapiens clone CCSBHm_00013738 NR3C1 (NR3C1) mRNA, encodes complete protein. KR710514 - Synthetic construct Homo sapiens clone CCSBHm_00013740 NR3C1 (NR3C1) mRNA, encodes complete protein. KR710515 - Synthetic construct Homo sapiens clone CCSBHm_00013744 NR3C1 (NR3C1) mRNA, encodes complete protein. X03348 - Human mRNA for beta-glucocorticoid receptor (clone OB10). AM183262 - Homo sapiens mRNA for glucocorticoid receptor (NR3C1 gene), [delta]313-338 isoform. FW340034 - Screening. X03225 - Human mRNA for alpha-glucocorticoid receptor (clone OB7). BC015610 - Homo sapiens nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor), mRNA (cDNA clone MGC:23072 IMAGE:4810424), complete cds. BX648553 - Homo sapiens mRNA; cDNA DKFZp779N1540 (from clone DKFZp779N1540). U01351 - Human glucocorticoid receptor alpha-2 mRNA, complete cds. JN797823 - Homo sapiens isolate hGR AS-1 glucocorticoid receptor (NR3C1) mRNA, complete cds, alternatively spliced. JN797824 - Homo sapiens isolate hGR AS-2 glucocorticoid receptor (NR3C1) mRNA, complete cds, alternatively spliced. MH938595 - Homo sapiens nuclear receptor subfamily 3 group C member 1 variant hGR-B(93) (NR3C1) mRNA, complete cds. MH938596 - Homo sapiens nuclear receptor subfamily 3 group C member 1 variant hGR-B(54) (NR3C1) mRNA, complete cds. MH938597 - Homo sapiens nuclear receptor subfamily 3 group C member 1 variant hGR-B(77) (NR3C1) mRNA, complete cds. AK223594 - Homo sapiens mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) variant, clone: FCC131A06. AK302050 - Homo sapiens cDNA FLJ50281 complete cds, highly similar to Glucocorticoid receptor. BX640610 - Homo sapiens mRNA; cDNA DKFZp686J22179 (from clone DKFZp686J22179). HQ450643 - Homo sapiens nuclear receptor subfamily 3 group C member 1 variant NS-1 (NR3C1) mRNA, complete cds. AB307716 - Homo sapiens NR3C1 mRNA for glucocorticoid receptor, complete cds. HQ692822 - Homo sapiens glucocorticoid nuclear receptor variant 1 (NR3C1) mRNA, complete cds. AK314789 - Homo sapiens cDNA, FLJ95659. EU446477 - Synthetic construct Homo sapiens clone IMAGE:100070215; IMAGE:100011686; FLH258225.01L nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1) gene, encodes complete protein. AB527290 - Synthetic construct DNA, clone: pF1KB9466, Homo sapiens NR3C1 gene for nuclear receptor subfamily 3, group C, member 1, without stop codon, in Flexi system. HQ450644 - Homo sapiens nuclear receptor subfamily 3 group C member 1 variant DL-1 (NR3C1) mRNA, complete cds. MK492111 - Homo sapiens nuclear receptor subfamily 3 group C member 1 (NR3C1) mRNA, complete cds. JD286259 - Sequence 267283 from Patent EP1572962. JD347397 - Sequence 328421 from Patent EP1572962. JD099326 - Sequence 80350 from Patent EP1572962. JD115152 - Sequence 96176 from Patent EP1572962. JD094746 - Sequence 75770 from Patent EP1572962. JD509520 - Sequence 490544 from Patent EP1572962. MA870519 - JP 2018536436-A/2355: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870520 - JP 2018536436-A/2356: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870521 - JP 2018536436-A/2357: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870522 - JP 2018536436-A/2358: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870523 - JP 2018536436-A/2359: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870524 - JP 2018536436-A/2360: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870525 - JP 2018536436-A/2361: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870526 - JP 2018536436-A/2362: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870527 - JP 2018536436-A/2363: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870528 - JP 2018536436-A/2364: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870529 - JP 2018536436-A/2365: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870530 - JP 2018536436-A/2366: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870531 - JP 2018536436-A/2367: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870532 - JP 2018536436-A/2368: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870533 - JP 2018536436-A/2369: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870534 - JP 2018536436-A/2370: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870535 - JP 2018536436-A/2371: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870536 - JP 2018536436-A/2372: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870537 - JP 2018536436-A/2373: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870538 - JP 2018536436-A/2374: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870539 - JP 2018536436-A/2375: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870540 - JP 2018536436-A/2376: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870541 - JP 2018536436-A/2377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870542 - JP 2018536436-A/2378: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870543 - JP 2018536436-A/2379: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870544 - JP 2018536436-A/2380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870545 - JP 2018536436-A/2381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870546 - JP 2018536436-A/2382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870555 - JP 2018536436-A/2391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870556 - JP 2018536436-A/2392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870557 - JP 2018536436-A/2393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870558 - JP 2018536436-A/2394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870559 - JP 2018536436-A/2395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870560 - JP 2018536436-A/2396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870561 - JP 2018536436-A/2397: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870628 - JP 2018536436-A/2464: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870629 - JP 2018536436-A/2465: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870630 - JP 2018536436-A/2466: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870631 - JP 2018536436-A/2467: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870640 - JP 2018536436-A/2476: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870641 - JP 2018536436-A/2477: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870642 - JP 2018536436-A/2478: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870643 - JP 2018536436-A/2479: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870644 - JP 2018536436-A/2480: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870645 - JP 2018536436-A/2481: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870646 - JP 2018536436-A/2482: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870663 - JP 2018536436-A/2499: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870664 - JP 2018536436-A/2500: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870665 - JP 2018536436-A/2501: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870666 - JP 2018536436-A/2502: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870667 - JP 2018536436-A/2503: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870668 - JP 2018536436-A/2504: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870669 - JP 2018536436-A/2505: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870670 - JP 2018536436-A/2506: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870671 - JP 2018536436-A/2507: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870672 - JP 2018536436-A/2508: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870673 - JP 2018536436-A/2509: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870674 - JP 2018536436-A/2510: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870675 - JP 2018536436-A/2511: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870676 - JP 2018536436-A/2512: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870677 - JP 2018536436-A/2513: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870678 - JP 2018536436-A/2514: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870688 - JP 2018536436-A/2524: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870689 - JP 2018536436-A/2525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870690 - JP 2018536436-A/2526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870691 - JP 2018536436-A/2527: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870692 - JP 2018536436-A/2528: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870693 - JP 2018536436-A/2529: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870710 - JP 2018536436-A/2546: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870711 - JP 2018536436-A/2547: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870712 - JP 2018536436-A/2548: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870713 - JP 2018536436-A/2549: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870714 - JP 2018536436-A/2550: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870715 - JP 2018536436-A/2551: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. MA870716 - JP 2018536436-A/2552: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592931 - KR 1020180133840-A/2355: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592932 - KR 1020180133840-A/2356: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592933 - KR 1020180133840-A/2357: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592934 - KR 1020180133840-A/2358: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592935 - KR 1020180133840-A/2359: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592936 - KR 1020180133840-A/2360: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592937 - KR 1020180133840-A/2361: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592938 - KR 1020180133840-A/2362: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592939 - KR 1020180133840-A/2363: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592940 - KR 1020180133840-A/2364: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592941 - KR 1020180133840-A/2365: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592942 - KR 1020180133840-A/2366: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592943 - KR 1020180133840-A/2367: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592944 - KR 1020180133840-A/2368: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592945 - KR 1020180133840-A/2369: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592946 - KR 1020180133840-A/2370: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592947 - KR 1020180133840-A/2371: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592948 - KR 1020180133840-A/2372: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592949 - KR 1020180133840-A/2373: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592950 - KR 1020180133840-A/2374: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592951 - KR 1020180133840-A/2375: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592952 - KR 1020180133840-A/2376: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592953 - KR 1020180133840-A/2377: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592954 - KR 1020180133840-A/2378: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592955 - KR 1020180133840-A/2379: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592956 - KR 1020180133840-A/2380: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592957 - KR 1020180133840-A/2381: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592958 - KR 1020180133840-A/2382: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592967 - KR 1020180133840-A/2391: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592968 - KR 1020180133840-A/2392: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592969 - KR 1020180133840-A/2393: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592970 - KR 1020180133840-A/2394: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592971 - KR 1020180133840-A/2395: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592972 - KR 1020180133840-A/2396: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY592973 - KR 1020180133840-A/2397: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593040 - KR 1020180133840-A/2464: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593041 - KR 1020180133840-A/2465: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593042 - KR 1020180133840-A/2466: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593043 - KR 1020180133840-A/2467: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593052 - KR 1020180133840-A/2476: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593053 - KR 1020180133840-A/2477: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593054 - KR 1020180133840-A/2478: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593055 - KR 1020180133840-A/2479: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593056 - KR 1020180133840-A/2480: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593057 - KR 1020180133840-A/2481: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593058 - KR 1020180133840-A/2482: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593075 - KR 1020180133840-A/2499: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593076 - KR 1020180133840-A/2500: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593077 - KR 1020180133840-A/2501: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593078 - KR 1020180133840-A/2502: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593079 - KR 1020180133840-A/2503: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593080 - KR 1020180133840-A/2504: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593081 - KR 1020180133840-A/2505: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593082 - KR 1020180133840-A/2506: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593083 - KR 1020180133840-A/2507: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593084 - KR 1020180133840-A/2508: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593085 - KR 1020180133840-A/2509: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593086 - KR 1020180133840-A/2510: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593087 - KR 1020180133840-A/2511: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593088 - KR 1020180133840-A/2512: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593089 - KR 1020180133840-A/2513: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593090 - KR 1020180133840-A/2514: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593100 - KR 1020180133840-A/2524: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593101 - KR 1020180133840-A/2525: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593102 - KR 1020180133840-A/2526: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593103 - KR 1020180133840-A/2527: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593104 - KR 1020180133840-A/2528: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593105 - KR 1020180133840-A/2529: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593122 - KR 1020180133840-A/2546: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593123 - KR 1020180133840-A/2547: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593124 - KR 1020180133840-A/2548: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593125 - KR 1020180133840-A/2549: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593126 - KR 1020180133840-A/2550: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593127 - KR 1020180133840-A/2551: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593128 - KR 1020180133840-A/2552: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. KU921432 - Homo sapiens BCRC-1 bladder cancer related circular RNA, complete sequence. DL490137 - Novel nucleic acids. AJ877169 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1H. AJ877170 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1C1. AJ877171 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1C2. AJ877172 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1C3. AJ888004 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene) splice variant 1G. AJ877168 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1F. AJ877167 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1E. AJ877166 - Homo sapiens partial mRNA for nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) (NR3C1 gene), splice variant 1D. MA870790 - JP 2018536436-A/2626: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. 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LY593257 - KR 1020180133840-A/2681: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593258 - KR 1020180133840-A/2682: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593259 - KR 1020180133840-A/2683: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593260 - KR 1020180133840-A/2684: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593261 - KR 1020180133840-A/2685: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593262 - KR 1020180133840-A/2686: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593263 - KR 1020180133840-A/2687: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593264 - KR 1020180133840-A/2688: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593265 - KR 1020180133840-A/2689: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593266 - KR 1020180133840-A/2690: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593267 - KR 1020180133840-A/2691: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593268 - KR 1020180133840-A/2692: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593269 - KR 1020180133840-A/2693: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593270 - KR 1020180133840-A/2694: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593271 - KR 1020180133840-A/2695: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593272 - KR 1020180133840-A/2696: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593273 - KR 1020180133840-A/2697: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593274 - KR 1020180133840-A/2698: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593275 - KR 1020180133840-A/2699: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593338 - KR 1020180133840-A/2762: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593339 - KR 1020180133840-A/2763: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593340 - KR 1020180133840-A/2764: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593341 - KR 1020180133840-A/2765: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593342 - KR 1020180133840-A/2766: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593343 - KR 1020180133840-A/2767: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593344 - KR 1020180133840-A/2768: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593345 - KR 1020180133840-A/2769: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593346 - KR 1020180133840-A/2770: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593347 - KR 1020180133840-A/2771: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593348 - KR 1020180133840-A/2772: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593349 - KR 1020180133840-A/2773: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593350 - KR 1020180133840-A/2774: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593351 - KR 1020180133840-A/2775: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593352 - KR 1020180133840-A/2776: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593353 - KR 1020180133840-A/2777: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593354 - KR 1020180133840-A/2778: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593355 - KR 1020180133840-A/2779: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593356 - KR 1020180133840-A/2780: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593357 - KR 1020180133840-A/2781: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593358 - KR 1020180133840-A/2782: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593359 - KR 1020180133840-A/2783: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593360 - KR 1020180133840-A/2784: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593361 - KR 1020180133840-A/2785: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593365 - KR 1020180133840-A/2789: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593366 - KR 1020180133840-A/2790: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593367 - KR 1020180133840-A/2791: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593368 - KR 1020180133840-A/2792: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593369 - KR 1020180133840-A/2793: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593370 - KR 1020180133840-A/2794: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593372 - KR 1020180133840-A/2796: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593373 - KR 1020180133840-A/2797: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593374 - KR 1020180133840-A/2798: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593375 - KR 1020180133840-A/2799: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593376 - KR 1020180133840-A/2800: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593377 - KR 1020180133840-A/2801: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593379 - KR 1020180133840-A/2803: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593380 - KR 1020180133840-A/2804: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593381 - KR 1020180133840-A/2805: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593382 - KR 1020180133840-A/2806: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593383 - KR 1020180133840-A/2807: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593384 - KR 1020180133840-A/2808: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593385 - KR 1020180133840-A/2809: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593386 - KR 1020180133840-A/2810: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593387 - KR 1020180133840-A/2811: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593388 - KR 1020180133840-A/2812: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593389 - KR 1020180133840-A/2813: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593390 - KR 1020180133840-A/2814: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593391 - KR 1020180133840-A/2815: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593392 - KR 1020180133840-A/2816: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593393 - KR 1020180133840-A/2817: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY. LY593394 - KR 1020180133840-A/2818: COMPOSITIONS AND METHODS FOR IMMUNOONCOLOGY.
Biochemical and Signaling Pathways
KEGG - Kyoto Encyclopedia of Genes and Genomes hsa04080 - Neuroactive ligand-receptor interaction
BioCarta from NCI Cancer Genome Anatomy Project h_hSWI-SNFpathway - Chromatin Remodeling by hSWI/SNF ATP-dependent Complexes h_nthiPathway - NFkB activation by Nontypeable Hemophilus influenzae h_vobesityPathway - Visceral Fat Deposits and the Metabolic Syndrome h_gcrPathway - Corticosteroids and cardioprotection
Reactome (by CSHL, EBI, and GO)
Protein P04150 (Reactome details) participates in the following event(s):
R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-376419 Formation of NR-MED1 Coactivator Complex R-HSA-383280 Nuclear Receptor transcription pathway R-HSA-212436 Generic Transcription Pathway R-HSA-73857 RNA Polymerase II Transcription R-HSA-74160 Gene expression (Transcription) R-HSA-8856930 EPAS1 (HIF2A) and activated NR3C1 (GCR) bind PTK6 gene R-HSA-9009085 DEXA:NR3C1 complex binds RUNX2 gene proximal promoter R-HSA-5618099 SH binds SHR within the HSP90 chaperone complex R-HSA-8849473 PTK6 Expression R-HSA-8939902 Regulation of RUNX2 expression and activity R-HSA-8848021 Signaling by PTK6 R-HSA-8878166 Transcriptional regulation by RUNX2 R-HSA-3371497 HSP90 chaperone cycle for steroid hormone receptors (SHR) R-HSA-9006927 Signaling by Non-Receptor Tyrosine Kinases R-HSA-212436 Generic Transcription Pathway R-HSA-2262752 Cellular responses to stress R-HSA-162582 Signal Transduction R-HSA-73857 RNA Polymerase II Transcription R-HSA-8953897 Cellular responses to external stimuli R-HSA-74160 Gene expression (Transcription)
US Server
