Human Gene CDX1 (ENST00000231656.13) from GENCODE V44
Description: Homo sapiens caudal type homeobox 1 (CDX1), mRNA. (from RefSeq NM_001804) RefSeq Summary (NM_001804): This gene is a member of the caudal-related homeobox transcription factor gene family. The encoded DNA-binding protein regulates intestine-specific gene expression and enterocyte differentiation. It has been shown to induce expression of the intestinal alkaline phosphatase gene, and inhibit beta-catenin/T-cell factor transcriptional activity. [provided by RefSeq, Jul 2008]. Gencode Transcript: ENST00000231656.13 Gencode Gene: ENSG00000113722.18 Transcript (Including UTRs) Position: hg38 chr5:150,166,778-150,184,558 Size: 17,781 Total Exon Count: 3 Strand: + Coding Region Position: hg38 chr5:150,166,877-150,183,680 Size: 16,804 Coding Exon Count: 3
ID:CDX1_HUMAN DESCRIPTION: RecName: Full=Homeobox protein CDX-1; AltName: Full=Caudal-type homeobox protein 1; FUNCTION: Could play a role in the terminal differentiation of the intestine. SUBCELLULAR LOCATION: Nucleus. TISSUE SPECIFICITY: Intestinal epithelium. SIMILARITY: Belongs to the Caudal homeobox family. SIMILARITY: Contains 1 homeobox DNA-binding domain.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Pfam Domains: PF04731 - Caudal like protein activation region PF00046 - Homeobox domain
ModBase Predicted Comparative 3D Structure on P47902
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
US Server
