Human Gene SPARC (ENST00000231061.9) from GENCODE V44
Description: Homo sapiens secreted protein acidic and cysteine rich (SPARC), transcript variant 1, mRNA. (from RefSeq NM_003118) RefSeq Summary (NM_003118): This gene encodes a cysteine-rich acidic matrix-associated protein. The encoded protein is required for the collagen in bone to become calcified but is also involved in extracellular matrix synthesis and promotion of changes to cell shape. The gene product has been associated with tumor suppression but has also been correlated with metastasis based on changes to cell shape which can promote tumor cell invasion. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2015]. Gencode Transcript: ENST00000231061.9 Gencode Gene: ENSG00000113140.11 Transcript (Including UTRs) Position: hg38 chr5:151,661,096-151,686,915 Size: 25,820 Total Exon Count: 10 Strand: - Coding Region Position: hg38 chr5:151,663,571-151,676,188 Size: 12,618 Coding Exon Count: 9
ID:SPRC_HUMAN DESCRIPTION: RecName: Full=SPARC; AltName: Full=Basement-membrane protein 40; Short=BM-40; AltName: Full=Osteonectin; Short=ON; AltName: Full=Secreted protein acidic and rich in cysteine; Flags: Precursor; FUNCTION: Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity. SUBCELLULAR LOCATION: Secreted, extracellular space, extracellular matrix, basement membrane. Note=In or around the basement membrane. DEVELOPMENTAL STAGE: Expressed at high levels in tissues undergoing morphogenesis, remodeling and wound repair. SIMILARITY: Belongs to the SPARC family. SIMILARITY: Contains 1 EF-hand domain. SIMILARITY: Contains 1 follistatin-like domain. SIMILARITY: Contains 1 Kazal-like domain. SEQUENCE CAUTION: Sequence=AAA60993.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Sequence of unknown origin in the C-terminal part; WEB RESOURCE: Name=Wikipedia; Note=Osteonectin entry; URL="http://en.wikipedia.org/wiki/Osteonectin";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on P09486
Front
Top
Side
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.
Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.