Human Gene KCNIP1 (ENST00000377360.8) from GENCODE V44
Description: Homo sapiens potassium voltage-gated channel interacting protein 1 (KCNIP1), transcript variant 3, mRNA. (from RefSeq NM_001034838) RefSeq Summary (NM_001034838): This gene encodes a member of the family of cytosolic voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs), which belong to the neuronal calcium sensor (NCS) family of the calcium binding EF-hand proteins. They associate with Kv4 alpha subunits to form native Kv4 channel complexes. The encoded protein may regulate rapidly inactivating (A-type) currents, and hence neuronal membrane excitability, in response to changes in the concentration of intracellular calcium. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, May 2013]. Gencode Transcript: ENST00000377360.8 Gencode Gene: ENSG00000182132.15 Transcript (Including UTRs) Position: hg38 chr5:170,353,487-170,735,935 Size: 382,449 Total Exon Count: 8 Strand: + Coding Region Position: hg38 chr5:170,353,877-170,735,806 Size: 381,930 Coding Exon Count: 8
ID:KCIP1_HUMAN DESCRIPTION: RecName: Full=Kv channel-interacting protein 1; Short=KChIP1; AltName: Full=A-type potassium channel modulatory protein 1; AltName: Full=Potassium channel-interacting protein 1; AltName: Full=Vesicle APC-binding protein; FUNCTION: Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND1/Kv4.1 and KCND2/Kv4.2 currents. Seems to be involved in KCND2 trafficking to the cell surface. SUBUNIT: Component of heteromultimeric potassium channels. Interacts with KCND3 and the N-terminal domain of KCND2. Probably part of a complex consisting of KCNIP1, KCNIP2 isoform 3 and KCND2. Self-associates to form homodimers and homotetramers. Interacts with KCNIP2 isoform 3 in a calcium-dependent manner. Interacts with Naja atra venom CTX3. INTERACTION: Q9NZV8:KCND2; NbExp=4; IntAct=EBI-2120635, EBI-1646745; Q9NS61-3:KCNIP2; NbExp=4; IntAct=EBI-2120635, EBI-1053010; SUBCELLULAR LOCATION: Cell membrane; Peripheral membrane protein (By similarity). TISSUE SPECIFICITY: Isoform 1 and isoform 2 are expressed in brain and kidney. Isoform 1 is also expressed in liver, pancreas, skeletal muscle, small intestine and testis. Isoform 2 is also expressed in lung, pancreas, leukocytes, prostate and thymus. SIMILARITY: Belongs to the recoverin family. SIMILARITY: Contains 4 EF-hand domains.
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NZI2
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0006811 ion transport GO:0006813 potassium ion transport GO:0034765 regulation of ion transmembrane transport GO:0071805 potassium ion transmembrane transport GO:1901379 regulation of potassium ion transmembrane transport
AK301775 - Homo sapiens cDNA FLJ52465 complete cds, highly similar to Homo sapiens Kv channel interacting protein 1 (KCNIP1), transcript variant 3, mRNA. DQ148476 - Homo sapiens potassium channel interacting protein 1 mRNA, complete cds, alternatively spliced. BC035032 - Homo sapiens Kv channel interacting protein 1, mRNA (cDNA clone IMAGE:5259689). BC050375 - Homo sapiens Kv channel interacting protein 1, mRNA (cDNA clone MGC:51879 IMAGE:5752207), complete cds. AY170821 - Homo sapiens vesicle APC-binding protein (VABP) mRNA, complete cds. AY780424 - Homo sapiens Kv channel interacting protein 1 mRNA, complete cds. AK074390 - Homo sapiens cDNA FLJ23810 fis, clone HRC08209, highly similar to Homo sapiens A-type potassium channel modulatory protein 1 (KCHIP1) mRNA. AB527490 - Synthetic construct DNA, clone: pF1KB7936, Homo sapiens KCNIP1 gene for Kv channel interacting protein 1, without stop codon, in Flexi system. KJ893743 - Synthetic construct Homo sapiens clone ccsbBroadEn_03137 KCNIP1 gene, encodes complete protein. AF199597 - Homo sapiens A-type potassium channel modulatory protein 1 (KCHIP1) mRNA, complete cds. DQ148477 - Homo sapiens potassium channel interacting protein 1 mRNA, complete cds, alternatively spliced. DQ148478 - Homo sapiens potassium channel interacting protein 1 mRNA, complete cds, alternatively spliced. DQ148479 - Homo sapiens potassium channel interacting protein 1 mRNA, complete cds, alternatively spliced. DL491713 - Novel nucleic acids. DL490294 - Novel nucleic acids.
Biochemical and Signaling Pathways
Reactome (by CSHL, EBI, and GO)
Protein Q9NZI2 (Reactome details) participates in the following event(s):
R-HSA-5577234 KCND tetramer:KCNIP tetramer transport K+ from cytosol to extrqcellular region R-HSA-5576894 Phase 1 - inactivation of fast Na+ channels R-HSA-5576891 Cardiac conduction R-HSA-397014 Muscle contraction
US Server
