Human Gene TXNDC5 (ENST00000379757.9) from GENCODE V44
Description: Homo sapiens thioredoxin domain containing 5 (TXNDC5), transcript variant 1, mRNA. (from RefSeq NM_030810)
RefSeq Summary (NM_030810): This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal endoplasmic reticulum (ER)-signal sequence, three catalytically active thioredoxin domains and a C-terminal ER-retention sequence. Its expression is induced by hypoxia and its role may be to protect hypoxic cells from apoptosis. Alternative splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream BLOC1S5 gene. [provided by RefSeq, Dec 2016].
Gencode Transcript: ENST00000379757.9
Gencode Gene: ENSG00000239264.9
Transcript (Including UTRs)
Position: hg38 chr6:7,881,517-7,910,788 Size: 29,272 Total Exon Count: 10 Strand: -
Coding Region
Position: hg38 chr6:7,883,144-7,910,776 Size: 27,633 Coding Exon Count: 10
Data last updated at UCSC: 2023-08-18 00:09:47
Sequence and Links to Tools and Databases
Comments and Description Text from UniProtKB
ID: TXND5_HUMAN
DESCRIPTION: RecName: Full=Thioredoxin domain-containing protein 5; AltName: Full=Endoplasmic reticulum resident protein 46; Short=ER protein 46; Short=ERp46; AltName: Full=Thioredoxin-like protein p46; Flags: Precursor;
FUNCTION: Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide- isomerase deficiency in yeast (By similarity).SUBCELLULAR LOCATION: Endoplasmic reticulum lumen (By similarity).SIMILARITY: Belongs to the protein disulfide isomerase family.SIMILARITY: Contains 3 thioredoxin domains.SEQUENCE CAUTION: Sequence=AAH01199.1; Type=Erroneous initiation;
Primer design for this transcript
Comparative Toxicogenomics Database (CTD)
RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
Microarray Expression Data
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mRNA Secondary Structure of 3' and 5' UTRs
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
Protein Domain and Structure Information
InterPro Domains: Graphical view of domain structure IPR005788 - Disulphide_isomerase
IPR005746 - Thioredoxin
IPR012336 - Thioredoxin-like_fold
IPR017937 - Thioredoxin_CS
IPR013766 - Thioredoxin_domain
Pfam Domains: PF00085 - Thioredoxin
Protein Data Bank (PDB) 3-D Structure
ModBase Predicted Comparative 3D Structure on Q8NBS9
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Gene Ontology (GO) Annotations with Structured Vocabulary
Descriptions from all associated GenBank mRNAs
BC052310 - Homo sapiens thioredoxin domain containing 5 (endoplasmic reticulum), mRNA (cDNA clone MGC:59718 IMAGE:6671945), complete cds.KJ901131 - Synthetic construct Homo sapiens clone ccsbBroadEn_10525 TXNDC5 gene, encodes complete protein.CU690906 - Synthetic construct Homo sapiens gateway clone IMAGE:100022387 5' read TXNDC5 mRNA.AY326464 - Homo sapiens putative protein STRF8 (STRF8) mRNA, complete cds.LF209758 - JP 2014500723-A/17261: Polycomb-Associated Non-Coding RNAs.MA445335 - JP 2018138019-A/17261: Polycomb-Associated Non-Coding RNAs.BC003529 - Homo sapiens cDNA clone IMAGE:3608717, partial cds.AK025006 - Homo sapiens cDNA: FLJ21353 fis, clone COL02771.BC001199 - Homo sapiens thioredoxin domain containing 5 (endoplasmic reticulum), mRNA (cDNA clone MGC:3178 IMAGE:3356029), complete cds.GQ891501 - Homo sapiens clone HEL-S-222 epididymis secretory sperm binding protein mRNA, complete cds.AL833008 - Homo sapiens mRNA; cDNA DKFZp666I134 (from clone DKFZp666I134).AY358646 - Homo sapiens clone DNA46776 disulfide isomerase (UNQ364) mRNA, complete cds.AL834423 - Homo sapiens mRNA; cDNA DKFZp667E126 (from clone DKFZp667E126).AK075291 - Homo sapiens cDNA FLJ90810 fis, clone Y79AA1000876, weakly similar to PROTEIN DISULFIDE ISOMERASE-RELATED PROTEIN PRECURSOR.AK098089 - Homo sapiens cDNA FLJ40770 fis, clone TRACH2004183, weakly similar to Aedes triseriatus disulfide-isomerase mRNA.LF331477 - JP 2014500723-A/138980: Polycomb-Associated Non-Coding RNAs.MA567054 - JP 2018138019-A/138980: Polycomb-Associated Non-Coding RNAs.JD080597 - Sequence 61621 from Patent EP1572962.JD036796 - Sequence 17820 from Patent EP1572962.JD454773 - Sequence 435797 from Patent EP1572962.LF331478 - JP 2014500723-A/138981: Polycomb-Associated Non-Coding RNAs.MA567055 - JP 2018138019-A/138981: Polycomb-Associated Non-Coding RNAs.JD439076 - Sequence 420100 from Patent EP1572962.JD039696 - Sequence 20720 from Patent EP1572962.JD498579 - Sequence 479603 from Patent EP1572962.JD037899 - Sequence 18923 from Patent EP1572962.LF331479 - JP 2014500723-A/138982: Polycomb-Associated Non-Coding RNAs.MA567056 - JP 2018138019-A/138982: Polycomb-Associated Non-Coding RNAs.JD488336 - Sequence 469360 from Patent EP1572962.JD268376 - Sequence 249400 from Patent EP1572962.JD181580 - Sequence 162604 from Patent EP1572962.JD544754 - Sequence 525778 from Patent EP1572962.JD297580 - Sequence 278604 from Patent EP1572962.JD251310 - Sequence 232334 from Patent EP1572962.JD225568 - Sequence 206592 from Patent EP1572962.JD289866 - Sequence 270890 from Patent EP1572962.JD061334 - Sequence 42358 from Patent EP1572962.LF331480 - JP 2014500723-A/138983: Polycomb-Associated Non-Coding RNAs.MA567057 - JP 2018138019-A/138983: Polycomb-Associated Non-Coding RNAs.DQ580398 - Homo sapiens piRNA piR-48510, complete sequence.DQ580397 - Homo sapiens piRNA piR-48509, complete sequence.JD140866 - Sequence 121890 from Patent EP1572962.JD394425 - Sequence 375449 from Patent EP1572962.JD503188 - Sequence 484212 from Patent EP1572962.JD150973 - Sequence 131997 from Patent EP1572962.DQ578913 - Homo sapiens piRNA piR-47025, complete sequence.LF331481 - JP 2014500723-A/138984: Polycomb-Associated Non-Coding RNAs.MA567058 - JP 2018138019-A/138984: Polycomb-Associated Non-Coding RNAs.AK315598 - Homo sapiens cDNA, FLJ96678, Homo sapiens thioredoxin domain containing 5 (TXNDC5), mRNA.AJ440721 - Homo sapiens mRNA for thioredoxin related protein.LF331482 - JP 2014500723-A/138985: Polycomb-Associated Non-Coding RNAs.MA567059 - JP 2018138019-A/138985: Polycomb-Associated Non-Coding RNAs.LF331483 - JP 2014500723-A/138986: Polycomb-Associated Non-Coding RNAs.MA567060 - JP 2018138019-A/138986: Polycomb-Associated Non-Coding RNAs.LF331485 - JP 2014500723-A/138988: Polycomb-Associated Non-Coding RNAs.MA567062 - JP 2018138019-A/138988: Polycomb-Associated Non-Coding RNAs.LF331487 - JP 2014500723-A/138990: Polycomb-Associated Non-Coding RNAs.MA567064 - JP 2018138019-A/138990: Polycomb-Associated Non-Coding RNAs.LF331488 - JP 2014500723-A/138991: Polycomb-Associated Non-Coding RNAs.MA567065 - JP 2018138019-A/138991: Polycomb-Associated Non-Coding RNAs.LF331490 - JP 2014500723-A/138993: Polycomb-Associated Non-Coding RNAs.MA567067 - JP 2018138019-A/138993: Polycomb-Associated Non-Coding RNAs.LF331493 - JP 2014500723-A/138996: Polycomb-Associated Non-Coding RNAs.MA567070 - JP 2018138019-A/138996: Polycomb-Associated Non-Coding RNAs.AK129666 - Homo sapiens cDNA FLJ26155 fis, clone ADG01203.LF331498 - JP 2014500723-A/139001: Polycomb-Associated Non-Coding RNAs.MA567075 - JP 2018138019-A/139001: Polycomb-Associated Non-Coding RNAs.LF331502 - JP 2014500723-A/139005: Polycomb-Associated Non-Coding RNAs.MA567079 - JP 2018138019-A/139005: Polycomb-Associated Non-Coding RNAs.JD094256 - Sequence 75280 from Patent EP1572962.JD393566 - Sequence 374590 from Patent EP1572962.
Biochemical and Signaling Pathways
Other Names for This Gene
Alternate Gene Symbols: ENST00000379757.1, ENST00000379757.2, ENST00000379757.3, ENST00000379757.4, ENST00000379757.5, ENST00000379757.6, ENST00000379757.7, ENST00000379757.8, NM_030810, Q5TCQ0, Q8NBS9, Q8ND33, Q8TCT2, Q9BVH9, TLP46, TXND5_HUMAN, uc003mxv.1, uc003mxv.2, uc003mxv.3, uc003mxv.4, uc003mxv.5, UNQ364/PRO700UCSC ID: ENST00000379757.9RefSeq Accession: NM_030810
Protein: Q8NBS9
(aka TXND5_HUMAN or TXN5_HUMAN)
CCDS: CCDS4505.1
Methods, Credits, and Use Restrictions
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for details on how this gene model was made and data restrictions if any.