Human Gene ZSCAN31 (ENST00000344279.11) from GENCODE V44
  Description: Homo sapiens zinc finger and SCAN domain containing 31 (ZSCAN31), transcript variant 1, mRNA. (from RefSeq NM_030899)
RefSeq Summary (NM_030899): This gene encodes a protein containing multiple C2H2-type zinc finger motifs. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016].
Gencode Transcript: ENST00000344279.11
Gencode Gene: ENSG00000235109.8
Transcript (Including UTRs)
   Position: hg38 chr6:28,324,737-28,336,148 Size: 11,412 Total Exon Count: 4 Strand: -
Coding Region
   Position: hg38 chr6:28,326,166-28,329,683 Size: 3,518 Coding Exon Count: 3 

Page IndexSequence and LinksUniProtKB CommentsPrimersCTDRNA-Seq Expression
RNA StructureProtein StructureOther SpeciesGO AnnotationsmRNA DescriptionsOther Names
Methods
Data last updated at UCSC: 2023-08-18 00:09:47

-  Sequence and Links to Tools and Databases
 
Genomic Sequence (chr6:28,324,737-28,336,148)mRNA (may differ from genome)Protein (406 aa)
Gene SorterGenome BrowserOther Species FASTAGene interactionsTable SchemaAlphaFold
BioGPSEnsemblEntrez GeneExonPrimerGencodeGeneCards
HGNCMGIneXtProtOMIMPubMedUniProtKB
BioGrid CRISPR DB

-  Comments and Description Text from UniProtKB
  ID: ZN323_HUMAN
DESCRIPTION: RecName: Full=Zinc finger protein 323;
FUNCTION: May function as a transcription factor. May be involved in the development of multiple embryonic organs.
SUBCELLULAR LOCATION: Nucleus (Probable).
TISSUE SPECIFICITY: Expressed at high levels in the lung, liver, and kidney, while weakly expressed in intestine, brain, muscle, cholecyst, heart, and pancreas.
SIMILARITY: Belongs to the krueppel C2H2-type zinc-finger protein family.
SIMILARITY: Contains 6 C2H2-type zinc fingers.
SIMILARITY: Contains 1 SCAN box domain.

-  Primer design for this transcript
 

Primer3Plus can design qPCR Primers that straddle exon-exon-junctions, which amplify only cDNA, not genomic DNA.
Click here to load the transcript sequence and exon structure into Primer3Plus

Exonprimer can design one pair of Sanger sequencing primers around every exon, located in non-genic sequence.
Click here to open Exonprimer with this transcript

To design primers for a non-coding sequence, zoom to a region of interest and select from the drop-down menu: View > In External Tools > Primer3


-  Comparative Toxicogenomics Database (CTD)
  The following chemicals interact with this gene

-  RNA-Seq Expression Data from GTEx (53 Tissues, 570 Donors)
  Highest median expression: 6.25 RPKM in Testis
Total median expression: 84.04 RPKM



View in GTEx track of Genome Browser    View at GTEx portal     View GTEx Body Map

-  mRNA Secondary Structure of 3' and 5' UTRs
 
RegionFold EnergyBasesEnergy/Base
Display As
5' UTR -37.70162-0.233 Picture PostScript Text
3' UTR -375.601429-0.263 Picture PostScript Text

The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.

-  Protein Domain and Structure Information
  InterPro Domains: Graphical view of domain structure
IPR008916 - Retrov_capsid_C
IPR003309 - Tscrpt_reg_SCAN
IPR007087 - Znf_C2H2
IPR015880 - Znf_C2H2-like
IPR013087 - Znf_C2H2/integrase_DNA-bd

Pfam Domains:
PF02023 - SCAN domain

ModBase Predicted Comparative 3D Structure on Q96LW9
FrontTopSide
The pictures above may be empty if there is no ModBase structure for the protein. The ModBase structure frequently covers just a fragment of the protein. You may be asked to log onto ModBase the first time you click on the pictures. It is simplest after logging in to just click on the picture again to get to the specific info on that model.

-  Orthologous Genes in Other Species
  Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
MouseRatZebrafishD. melanogasterC. elegansS. cerevisiae
No orthologNo orthologNo orthologNo orthologNo orthologNo ortholog
      
      
      
      
      

-  Gene Ontology (GO) Annotations with Structured Vocabulary
  Molecular Function:
GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003700 transcription factor activity, sequence-specific DNA binding
GO:0046872 metal ion binding

Biological Process:
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter

Cellular Component:
GO:0005634 nucleus


-  Descriptions from all associated GenBank mRNAs
  BC065241 - Homo sapiens zinc finger protein 323, mRNA (cDNA clone MGC:70898 IMAGE:6016003), complete cds.
AF513019 - Homo sapiens zinc finger protein 323 (ZNF323) mRNA, complete cds.
AK027060 - Homo sapiens cDNA: FLJ23407 fis, clone HEP19601.
AK225382 - Homo sapiens mRNA for zinc finger protein 323 isoform 2 variant, clone: HEP19601.
AK095261 - Homo sapiens cDNA FLJ37942 fis, clone CTONG2008595, highly similar to Zinc finger protein 323.
AL833617 - Homo sapiens mRNA; cDNA DKFZp686E1473 (from clone DKFZp686E1473).
AL833416 - Homo sapiens mRNA; cDNA DKFZp313M0722 (from clone DKFZp313M0722).
BC008490 - Homo sapiens zinc finger protein 323, mRNA (cDNA clone MGC:14819 IMAGE:4248596), complete cds.
JD532753 - Sequence 513777 from Patent EP1572962.
JD553983 - Sequence 535007 from Patent EP1572962.
JD565762 - Sequence 546786 from Patent EP1572962.
JD244143 - Sequence 225167 from Patent EP1572962.
JD469609 - Sequence 450633 from Patent EP1572962.
JD538797 - Sequence 519821 from Patent EP1572962.
JD203034 - Sequence 184058 from Patent EP1572962.
JD526453 - Sequence 507477 from Patent EP1572962.
JD265463 - Sequence 246487 from Patent EP1572962.
AK057702 - Homo sapiens cDNA FLJ33140 fis, clone UTERU1000160, moderately similar to ZINC FINGER PROTEIN 191.
JD282569 - Sequence 263593 from Patent EP1572962.
JD500155 - Sequence 481179 from Patent EP1572962.
JD114886 - Sequence 95910 from Patent EP1572962.
CU678983 - Synthetic construct Homo sapiens gateway clone IMAGE:100016769 5' read ZNF323 mRNA.
KJ903071 - Synthetic construct Homo sapiens clone ccsbBroadEn_12465 ZNF323 gene, encodes complete protein.
KJ905526 - Synthetic construct Homo sapiens clone ccsbBroadEn_15134 ZNF323 gene, encodes complete protein.
EU446673 - Synthetic construct Homo sapiens clone IMAGE:100069990; IMAGE:100011882; FLH258260.01L zinc finger protein 323 (ZNF323) gene, encodes complete protein.
AB464390 - Synthetic construct DNA, clone: pF1KB8279, Homo sapiens ZNF323 gene for zinc finger protein 323, without stop codon, in Flexi system.
JD171755 - Sequence 152779 from Patent EP1572962.
JD187801 - Sequence 168825 from Patent EP1572962.
JD334831 - Sequence 315855 from Patent EP1572962.
JD178453 - Sequence 159477 from Patent EP1572962.
JD422754 - Sequence 403778 from Patent EP1572962.
JD464544 - Sequence 445568 from Patent EP1572962.
JD054483 - Sequence 35507 from Patent EP1572962.
JD448404 - Sequence 429428 from Patent EP1572962.

-  Other Names for This Gene
  Alternate Gene Symbols: ENST00000344279.1, ENST00000344279.10, ENST00000344279.2, ENST00000344279.3, ENST00000344279.4, ENST00000344279.5, ENST00000344279.6, ENST00000344279.7, ENST00000344279.8, ENST00000344279.9, NM_030899, Q8WWS5, Q96LW9, uc003nlc.1, uc003nlc.2, uc003nlc.3, uc003nlc.4, uc003nlc.5, ZN323_HUMAN, ZNF310P, ZNF323
UCSC ID: ENST00000344279.11
RefSeq Accession: NM_030899
Protein: Q96LW9 (aka ZN323_HUMAN or Z323_HUMAN)

-  Methods, Credits, and Use Restrictions
  Click here for details on how this gene model was made and data restrictions if any.